Basic Information

Gene Symbol
-
Assembly
GCA_900474315.1
Location
UXGD01001784.1:20680-24395[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0075 0.77 11.0 0.1 1 20 41 60 41 61 0.95
2 17 4.9e-05 0.005 17.9 0.5 1 21 79 99 79 100 0.95
3 17 5.1e-06 0.00053 21.0 1.2 2 23 137 159 136 159 0.96
4 17 0.0028 0.29 12.4 0.6 3 23 165 186 163 186 0.94
5 17 0.0014 0.14 13.3 1.1 3 23 194 214 193 214 0.95
6 17 1.7e-05 0.0018 19.3 1.6 2 23 222 244 221 244 0.95
7 17 0.041 4.2 8.7 6.5 1 23 253 275 253 275 0.97
8 17 0.12 12 7.2 0.6 3 23 283 302 283 302 0.98
9 17 4.4e-05 0.0045 18.1 0.7 3 23 310 330 309 330 0.97
10 17 3e-05 0.0031 18.6 4.9 1 23 336 358 336 359 0.96
11 17 0.043 4.4 8.6 2.7 1 23 567 589 567 589 0.98
12 17 0.00018 0.019 16.1 4.1 1 23 622 644 622 644 0.97
13 17 0.097 10 7.5 1.1 3 23 666 687 664 687 0.91
14 17 0.0034 0.35 12.1 3.3 1 23 696 718 696 718 0.98
15 17 0.0013 0.14 13.4 0.1 2 23 725 745 724 745 0.97
16 17 1.8e-06 0.00019 22.4 1.2 1 23 751 773 751 773 0.98
17 17 2.1e-05 0.0022 19.1 0.4 1 23 779 801 779 801 0.97

Sequence Information

Coding Sequence
ATGAACACCGTTAATCGCGTGATCGTCCTGAAGCCGACAGCCATTGTCCCTGACAACGAACAAATAAAACAAGAAGAAGTCGAAGTAATAGACAATTACGCGAATAACGGGGAGCATGCTTACCAGTGCGATTCGTGCGACGAACTTTTTCCCGATCGCTCAACTTTGATCATTCATAAAACCGAAAAGTCTATTTTAAGAACGCGAGTAGCGTTGAGAGAGCCACTTGTTAAGTACACGTGTGAGATGTGCAATCGGTCGTTCGTCTCGAAGGGTATGTACGAGCGACACTACAAGATCTGCGGTTTCGTCGAGGTCGACGACATGCCAGCGACCGGCCGTCGGCGACGAGTACAAACTCGGGCGGAGCCGAGGAAGGTGAACGAAACCGGCGAGGAAGAGCCATCGACGTGCCAGAAATGCGGCAAGATCTTCAAGAAGGCGAAGTACCTGAAGGTCCACATGACGACCGCGCACGGTGAGCACATAATATGTCAGATCTGCGACACCAAGTGCGATACGATGACGTTGCTGAAGGCCCACATGAACGAGGAGCACAGCGGTGACTTTACTGAGCATTGTCAGATCTGCAACAAAGGCTTTTACCTCAGGCAATCGTTGAAGGTCCACATGGCGGCGCATCTGCGCGACGATAATCCGAGCACTTGCGAGCAATGCGGCAAGAACTTCCGGCACGAGGTTTATCTGAAGAAACATATACAGCTCGTGCATGTCGATGTGCAGGAGAGAAAACGCTTTAACTGCGAGGAGTGCGACTACGAGACCAGTCACAAGACCTGCTTCCGCGAGCACATGTACAAGCACACGGGCGAGGATATCATTGGCTGCGAGGTATGCGGTAAGCAGATGCGCAGAAGCTACCTCAGGATACATTCCCGAATACACACGGGTGAGAAACCAGAGATATGCGAGTTCTGCGGCAAGGCCTTCAGTGCCAGGAAGTACCTGACGAAGCACAGGATTACTCATACTGGTGAGAAGCCTTACGAGTGCCAGAAGTGCGGTAAGAAGTATACCCAACGTGGCACGTTGACGATGCATTTCAGGCGGCATCATCCAGAGGAGGCAAACACGTGGATCGCCAAAGGCCCGGGCAGAAGGCCGAATTTCGAAAAGAACAAGGAAAGGGATAATGAAGTTAAACGCGGGATGGTCATTAGCGAGGATGGAACGTTAgtggaaaagaaagaagagcagGAGGGAGAGGAACAAGTGAAGGAGATGGTGGATGAGGAAGAGGAAGGAATGAAAGAGATGTTAAatgaggaagaggaagaagcgAAATCCATGGTATatgaggaagaggaagaagcgAAACCCATGGTATatgaggaagaggaagaagcgAAAGAGATGGTAGATGAGGAAGTGGAAGAACCGAACGAGATGGTATATGAGGAAGAGGAAGAAACAAAGGAGATGGTAgatgaagaagaggaagaggtgaatgaggaagaggaggaagacTTTGCTGATGAAGAAGGTGATATTATAATTCGTGAAGTAGCTGTAGACGAGGAGGATGTGTTGGGAGAGGATGAAGTGCAAAACGAAGAAGGCGAGAATTTAAAGCAGGAGTTAGATGAAGAGGAGAAATACTTCATCATCACCACCACGACTATCACAACCAGCAACAGTAACAGCAGCAGTTCCTCAAAACCCAAACCACGCCGACAGCACAAGTGCCGACTCTGCTCGCAGCTCTTCCCAACCAAACCACAGCTCGCTTTGCACGTGCACACGCACACGAAGAAGAGATATGGCTGCAACTTCTGCGGTGAGCCTCAATTGTCGGCCGACGCTCTCAGCCAACATCTCGGCAAGCAGCATCCGAATCTCAGCTTTCGCTGTGACATCTGCGGCAAATTTTACTGTAGCAATCGGGCGCTAAATCTCCACAAACGTTTCCACAATACCAGGCGCACCAAAGCAAATAGCAACAAAAAGAAGAGCGACGCTGACGATAGACACTTGTGTCTTGTGTGCAACGCGAGTTACAGCTCTCTCGCGTATCTGAAGCTACACTCGAAGTTGCGTCATGCCGATCCGGACTCGCGGCAGTTGTTCAAGTGCAACGAGTGCGATTTCGTCAGCTACTACAGGACGAATATGAGGAAACACTCGAGGAGTCATACTGGGGAGAACCTCGTGCCGTGCAATGTTTGCGGCAAAGCCGTGAATAAGACTTACATGACCATACACATGAGGATACATACCGGTGAGAAACCGCACGTTTGCGATGACTGCGGCAAGGCGTTCAGCGTGAAGAAGTACCTGGTGGTGCACAAAAGAACGCACACGGGCGAACGACCCTTCGCTTGCAAATTTTGCGACAAACGGTTCACCCAGGAATCGCCATTGGCTGCACACGTTAAGAGCCACTTGCGGAAGACCGAATTTGGTGGCAACGGATAA
Protein Sequence
MNTVNRVIVLKPTAIVPDNEQIKQEEVEVIDNYANNGEHAYQCDSCDELFPDRSTLIIHKTEKSILRTRVALREPLVKYTCEMCNRSFVSKGMYERHYKICGFVEVDDMPATGRRRRVQTRAEPRKVNETGEEEPSTCQKCGKIFKKAKYLKVHMTTAHGEHIICQICDTKCDTMTLLKAHMNEEHSGDFTEHCQICNKGFYLRQSLKVHMAAHLRDDNPSTCEQCGKNFRHEVYLKKHIQLVHVDVQERKRFNCEECDYETSHKTCFREHMYKHTGEDIIGCEVCGKQMRRSYLRIHSRIHTGEKPEICEFCGKAFSARKYLTKHRITHTGEKPYECQKCGKKYTQRGTLTMHFRRHHPEEANTWIAKGPGRRPNFEKNKERDNEVKRGMVISEDGTLVEKKEEQEGEEQVKEMVDEEEEGMKEMLNEEEEEAKSMVYEEEEEAKPMVYEEEEEAKEMVDEEVEEPNEMVYEEEEETKEMVDEEEEEVNEEEEEDFADEEGDIIIREVAVDEEDVLGEDEVQNEEGENLKQELDEEEKYFIITTTTITTSNSNSSSSSKPKPRRQHKCRLCSQLFPTKPQLALHVHTHTKKRYGCNFCGEPQLSADALSQHLGKQHPNLSFRCDICGKFYCSNRALNLHKRFHNTRRTKANSNKKKSDADDRHLCLVCNASYSSLAYLKLHSKLRHADPDSRQLFKCNECDFVSYYRTNMRKHSRSHTGENLVPCNVCGKAVNKTYMTIHMRIHTGEKPHVCDDCGKAFSVKKYLVVHKRTHTGERPFACKFCDKRFTQESPLAAHVKSHLRKTEFGGNG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01465609;
90% Identity
-
80% Identity
-