Basic Information

Gene Symbol
-
Assembly
GCA_900474315.1
Location
UXGD01012828.1:1857-3928[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.24 25 6.3 0.7 2 23 99 120 98 120 0.97
2 15 2.4e-05 0.0025 18.9 1.2 2 23 125 146 125 146 0.98
3 15 7.6e-06 0.00078 20.4 2.5 2 23 153 174 152 174 0.97
4 15 8.7e-07 9e-05 23.4 1.7 1 23 208 230 208 230 0.98
5 15 0.0002 0.021 16.0 0.9 1 23 236 258 236 258 0.98
6 15 4e-06 0.00041 21.3 2.3 1 23 264 286 264 286 0.97
7 15 1e-06 0.00011 23.2 1.8 1 23 292 314 292 314 0.96
8 15 6.3e-05 0.0065 17.5 0.4 1 23 320 342 320 342 0.98
9 15 2.3e-05 0.0024 18.9 8.4 1 23 348 370 348 370 0.97
10 15 2.4e-08 2.4e-06 28.3 0.6 1 23 375 397 375 397 0.97
11 15 0.00016 0.017 16.3 0.4 1 23 403 425 403 425 0.97
12 15 1.5e-05 0.0015 19.5 6.7 1 23 431 453 431 453 0.97
13 15 3.9e-06 0.0004 21.4 0.7 1 23 459 481 459 481 0.99
14 15 2.7e-06 0.00027 21.9 0.5 1 23 488 510 488 510 0.99
15 15 0.0001 0.011 16.9 1.3 2 23 517 539 517 539 0.96

Sequence Information

Coding Sequence
ATGGATGAAAATATTGTAAGCATTGTATTCAAGGAAGAACCAggagaaaaatacaaatcaaaCTACATGGAGGATATTTGTTTGGGGACTTTTGATAAGGTTTTTCAACCCGTCAATCATCATGAGGTGGATTTTCCTGATGACATGGTTAAATTGGAATTAGACACAGAAAATAATCACCATCACTGGGCAGCTCAGTTGGCAAATGCAACACTGTCTGAAAATGGCGAATATGGATTGCAAGCAGATCATCACTTTCTTAATTCAAGTGCAgtccaaaaattttataaaattcagtgtaCACTctgtaaaaaatggtttttgaaCAATGATTCTATGGTGACACATTTAAAAATGCATTGTAGTGGTAATACTTGTGAAGTTTGTCATCAGAGTTTCATCGATAATGCAGGTCTACATGCACACATGTTAACTCATGTTGGTATGAGTCCAGTAGAATGTACAATATGTCAAAAAAGGTTTGCTTATAAATGGTGTTTACGCAATCACATGCAAACTCATATGACAAATAAACAGTTTGAGTATGATAGTTTACAACAAGTTTTTCTGAAGAGATATAGTCAAAGCAATGATCATATGATTCGTGATGAAGGAAGGCCTTACATGTGTCACATTTGTCAAACATCATTTCgagaaaaaggaaatttaaGTCGTCATATGATAATTCATAGCGGGGACAAACCACATAAATGTGATATTTGTTTTGCTTCTTTTCGAGAAAAAGCAAAACTAAACATACACATATCAATTCACACTGGtcataaacaatttaaatgtaCAATGTGTCATCGATCTTTTGCACAGAAAACGGCATTAAGTAATCATATGTTAGCACATAGTGGTGAAAAACCTCATGCTTgtaatatttgtgaaaaaacatACAAACGAAAATCTGAATTAATAAGACATACAATGATTCATACTGGAGAACGACCATATGAATGTCAAGAGTGTTTAATGACTTTTAGAGAAAAAGCAAAACTCAACTCTCACATGTTGGTTCATACAGGTGAAAAGCCACATGAGTGCCATATATGTCATAAAACTTGTGCTCGTAAATCAGATTTAAATAGTCATATGCTATCACATACTGGTGGCCAATATGACTGTAAAGTTtgtgataaaattttcactcgTAAATCAGATTTAAATAGACATATTTTGGTTCATACTGGTGAGAAACCTTATGCTTGTGAATATTGCAATATGGCTTTTCGAGAAAAGACAAGACTCAATTCGCACATGGTTATTCATACTGGAGATAAAAGGCATATTTGTCATATTTGTCATAAGGGCTTCCGAGAAAAATCAATGTTGAGAAAGCATATGTTAAGTCATACTGGTGATCGACCTTATGAATGTTATTTATGTCAGAAAGCATTTGCGCAAAAAACAACTCTTAATAGTCACATTCTGACGCATACAACTGAAGAATCATCCTATGAATGCACTATATGTAGAAAAGTTTATAGAGACAGAATTGCATTAAAGAAACATCTTATAACACATGCAACAggcaaaaataatgaatgtcctatatgtttaaaaaaatttactcacAAAATAGCATTGAGTAATCATATAACAACAAATCATTCTTTGTAA
Protein Sequence
MDENIVSIVFKEEPGEKYKSNYMEDICLGTFDKVFQPVNHHEVDFPDDMVKLELDTENNHHHWAAQLANATLSENGEYGLQADHHFLNSSAVQKFYKIQCTLCKKWFLNNDSMVTHLKMHCSGNTCEVCHQSFIDNAGLHAHMLTHVGMSPVECTICQKRFAYKWCLRNHMQTHMTNKQFEYDSLQQVFLKRYSQSNDHMIRDEGRPYMCHICQTSFREKGNLSRHMIIHSGDKPHKCDICFASFREKAKLNIHISIHTGHKQFKCTMCHRSFAQKTALSNHMLAHSGEKPHACNICEKTYKRKSELIRHTMIHTGERPYECQECLMTFREKAKLNSHMLVHTGEKPHECHICHKTCARKSDLNSHMLSHTGGQYDCKVCDKIFTRKSDLNRHILVHTGEKPYACEYCNMAFREKTRLNSHMVIHTGDKRHICHICHKGFREKSMLRKHMLSHTGDRPYECYLCQKAFAQKTTLNSHILTHTTEESSYECTICRKVYRDRIALKKHLITHATGKNNECPICLKKFTHKIALSNHITTNHSL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01469925;
90% Identity
iTF_01469074;
80% Identity
-