Basic Information

Gene Symbol
ZFX
Assembly
GCA_947859335.1
Location
OX401985.1:9204188-9217138[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0071 0.45 11.4 2.2 2 23 69 90 68 90 0.96
2 12 0.016 1 10.2 0.6 2 23 97 119 96 119 0.94
3 12 0.092 5.9 7.9 0.3 2 23 127 149 126 149 0.93
4 12 4.2e-05 0.0027 18.4 5.1 1 23 155 177 155 177 0.97
5 12 2.2e-05 0.0014 19.3 3.6 1 23 183 205 183 205 0.98
6 12 0.18 12 7.0 5.2 1 23 211 234 211 234 0.95
7 12 0.028 1.8 9.5 1.1 3 23 252 273 251 273 0.89
8 12 0.00026 0.016 15.9 5.6 1 23 567 589 567 589 0.98
9 12 3.6e-05 0.0023 18.6 4.0 1 23 596 618 596 618 0.98
10 12 2.3e-05 0.0015 19.2 0.1 1 23 626 650 626 650 0.97
11 12 9.8e-06 0.00063 20.4 2.4 1 23 656 680 656 680 0.98
12 12 0.00016 0.01 16.6 1.1 1 22 686 707 686 707 0.97

Sequence Information

Coding Sequence
ATGGAATCAAGTCTATCATTCTTTAGTCTACCATTCGTGGACTCAGAAAGTACGGACTTGGTGCTAAACATCAAGAATGATAACCTATTGCACACGAGTCTACCGTCGCATGGAAGCTTGCTGGGCGCAGACGACGTTCTGGCCCAGTTTCTGTCCCCAGACGAGCCACTTGATGAGCCTGACCTCAATGGGCCCACCACTTTGCATTGCGAGATTTGCAGGAAGAAATTTGATAATGCTAAGAAGTACTATGGACATTTGAGAATTCACTCCAAGGGCAATGCTTGGGTTTGCGACAAGTGCCCGGAGCAAAAGTTTGCTACAAAGCAGCACCTGATGAAGCATGCACTGATACATGCACCACTGGAACGTGTGTGGCGCTGTCCACAGTGTAGCATGTCCTTCGAGGCGCTTTGGAGGCTGCAGCAGCACCTTTTCTCCACACATCTGGAGTACAAGCCACATAAATGTGATGAATGTGATAAGGCATTCCATAAGAAATCAGACTTAACGAGACATAAAGACATGCATAGCAGTATTAAAAGATTTTCATGTAGTGTCTGTCGTGTGGCATTCAAAGACAAGTGCAACCTCAAGAGACACATGCTGCGCCACACCAATGAGAAGCCCTACTGCTGTGTTGGGTGCGGGAATAGGTACAAACAGTTGGCATCAATGAAGAGACATAGCCAGAAGTGCCATAAGAATCAGTATAGCAATAACAACATAGACCCAACAGTCCGCAAGAATCATTGCAGAGTCTGCGGCATGACATTCCAATATAAGAGTGCTTTGCTGGAACACAGTGTCAGGCAACACACTAATCCAAGTAACCCTCTGAATAATAATTATAATATAGAAAAGGAAGACAAACAAATCAACAAATCGGTTCAACTCCACATAGACCACAACAGAACTGTGGACAAAATCGTCGACGACATCCTCTCTGCTGAAGACGACTACATGACAATGTCCACGCAAAACAAAATACTAAATGTCTATAACACCCAAAGCGAAACGGACAACAATAATGATAACCTGATGCATGTGGAGTTTCTAAAAGCCATGAACCAGCTACACAGTCTAGACGATGAGTTATTCTACAATGATCTTGACCTTGACAACTTCCAAGCTAACCACATATTTAACATGAACACAAACGACATGGATTACGGCGACAAAAATGGCGAAATCCTATTCGATTTTGCTGATGGCGGCCGAAGCATGGATCAAGATATAATTAATGTACTTTCTGAAGTAGGTCCAAGTTTTACAGAGACAAATAAGGCTGAACCCATCAAGAATCCCCCAGTTTCTGTCAACGAATGTGCTACTATCTTTGAAAGTGATGTAGATTTGGAAGCTAGTACGAATTTAGCGGCGAATTTGAATCAGCTGATTGGGGAAAATAGGGTGCAATATATTTCAACTGAGGATGATGATACATTTATTATTAGTTTAAACAATGCTATTGACGCGGAACAGTTGGCTGACATGCTGAATATAGGAGTTGAATTTATGGGAAATAATAATAATAATAATAATCAAGAAGCGAAGGCACCAGAAGTTGAGTATGCTGCTGAGGTAGACAGTGAACCAATTGTAATCAAAATTGAAGAGCCTCTTGTTGCAAATAAAGAAGCTTCTGATGATAAAGAAAACGCTGCAGTTAAACAGAAAGTGAAGAAGTGTACTTTGTTCGTTTGCTGCACGTGTAACAAGGTTTTTAAGAAAAAGGATAACTACAAATCACATAAAGCGACCCACAACCCGGCGCTGCGCGCGCACCGCTGCCGCACATGCGGCGCCCGCTTCAGCTACCGCTCGACGCTGAACAAGCACGCGCGCACGCACCAGCCCGTGCACACCGAGCAGTTCCAGTGCCCCGAGGGCTGCGGGAAGGTGTACCGCGCTCAGTGGATGTTGAAAACTCACATGGAGCGCGACCACGACAAGCTGACGCCGTACAAATGCGATAAGAAGGACTGCGGCAAGAGATTCTACAAGCAATCAGATTTGGTGAAACACGAGCGATACCATTCGGGCGAGAGACCGTACTCGTGCGACATCTGCCGTCGGGCTTTCCTGCAGATCTCGCACCTCAAACGTCATATGCGGACTGTTGATTGCACAAAAAAGTGA
Protein Sequence
MESSLSFFSLPFVDSESTDLVLNIKNDNLLHTSLPSHGSLLGADDVLAQFLSPDEPLDEPDLNGPTTLHCEICRKKFDNAKKYYGHLRIHSKGNAWVCDKCPEQKFATKQHLMKHALIHAPLERVWRCPQCSMSFEALWRLQQHLFSTHLEYKPHKCDECDKAFHKKSDLTRHKDMHSSIKRFSCSVCRVAFKDKCNLKRHMLRHTNEKPYCCVGCGNRYKQLASMKRHSQKCHKNQYSNNNIDPTVRKNHCRVCGMTFQYKSALLEHSVRQHTNPSNPLNNNYNIEKEDKQINKSVQLHIDHNRTVDKIVDDILSAEDDYMTMSTQNKILNVYNTQSETDNNNDNLMHVEFLKAMNQLHSLDDELFYNDLDLDNFQANHIFNMNTNDMDYGDKNGEILFDFADGGRSMDQDIINVLSEVGPSFTETNKAEPIKNPPVSVNECATIFESDVDLEASTNLAANLNQLIGENRVQYISTEDDDTFIISLNNAIDAEQLADMLNIGVEFMGNNNNNNNQEAKAPEVEYAAEVDSEPIVIKIEEPLVANKEASDDKENAAVKQKVKKCTLFVCCTCNKVFKKKDNYKSHKATHNPALRAHRCRTCGARFSYRSTLNKHARTHQPVHTEQFQCPEGCGKVYRAQWMLKTHMERDHDKLTPYKCDKKDCGKRFYKQSDLVKHERYHSGERPYSCDICRRAFLQISHLKRHMRTVDCTKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00156531;
90% Identity
-
80% Identity
-