Basic Information

Gene Symbol
MBD2
Assembly
GCA_030247195.1
Location
CM058069.1:427120638-427122500[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4e-24 6.3e-20 72.6 0.0 1 73 5 72 5 76 0.91
2 2 0.0003 4.6 8.9 0.0 29 74 136 191 121 194 0.88

Sequence Information

Coding Sequence
ATGAATGTTTCCATCGAAAAGAAACGAGCGGACTGTGCGGCACTGCCGAAAGGATGGCAACGAGAGGAAGTTCTCCGGAAAACTGGACTATCCGCTGGCAAAGTAGACGTATACTATTATAGTCCAACGGGTAAAAAGATCGAAAGTAAACCGCAACTAGCCCGAGCACTCGGGGACACTATCGACCTGTCTACGTTTGATTATCAAGCCGGTCGGATCGTACCGAATGCAACGCATATGATGTTGCAGCACAATGCACTCAAAAGGAAATTAGGTGGTCCAGTGGCAGCAGGTGCTCCCCTAGTTCCAAGTCCAACGCTACCGCCACCTGTTCCGATTTATCATCAGTTTTCCAGTGGCGCAGGTGGAAGACAGCCGCACCAGCAGTATGAATACAGTCGAGGAATGCGGGCGGATACTTCCTTAATCCCACCGATTCGGCAGACAGCGTCCATTTTCAAGCAGCCAGTAACAGTCGTCCGGTCTCAGGACAGTGATAGCAAAGTTAAGCGGGAGCTACAACATGGCTCCCAGATCAAACCGAAGCAACTGTTTTGGGAGAAACGGCTGGAGAATCTCCGTGCCAACAACACGTTCAACGAAGAGATCGGTTCCCTGGAGCTTCCCAAGCGCCTCAAAGCTGTTGGTCCTGGGGTAAATGAAGCCACAGTGCTACAATCGCTAGCCACAGCACTGCATCACAATACCCATCCTGTAACTGGACAAACCGCTTCCAAGACTTCATTGAACACAAACGCCGGAGTTTTTCTCAATCCGGATCAGCCACTGATGCATGTAACCACCGTCACTGAGGATGATATTAAACGACAAGAGGAGCGAGTTCAGTTCGCCCGTTCCCGACTGCAAGAGGCTTTGCGGGCGTAA
Protein Sequence
MNVSIEKKRADCAALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKIESKPQLARALGDTIDLSTFDYQAGRIVPNATHMMLQHNALKRKLGGPVAAGAPLVPSPTLPPPVPIYHQFSSGAGGRQPHQQYEYSRGMRADTSLIPPIRQTASIFKQPVTVVRSQDSDSKVKRELQHGSQIKPKQLFWEKRLENLRANNTFNEEIGSLELPKRLKAVGPGVNEATVLQSLATALHHNTHPVTGQTASKTSLNTNAGVFLNPDQPLMHVTTVTEDDIKRQEERVQFARSRLQEALRA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00948753;
90% Identity
iTF_00948753;
80% Identity
-