Tcin028451.1
Basic Information
- Insect
- Tolmerus cingulatus
- Gene Symbol
- MBD-R2
- Assembly
- GCA_959613345.1
- Location
- OY390709.1:24040200-24044068[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.1e-20 1.4e-16 61.2 0.1 4 76 389 459 386 460 0.93
Sequence Information
- Coding Sequence
- ATGACGCGAAAATGTGTAATTGAGGGTTGCACTTCGAAATCTGGAAAACCTCAATACCGAGGAGTGACTTTTCACTCGTTTCCCTTTGATTCAAAGACTCGAGAAAAGTGGATCATTAATTGCCACTTACCGGCTgataaaaatatcacaaagAGTGTTTTAGTATGTTCCAGGCACTTTCGACGAGCTGATTTTCAACCAATGAAGTCAAACAAGTATTTACTTAAACAGGGAGCAATGCCCACAATTTTCCCATGGGGCAAACTGGATTATGTTGAACCCGCCATATCTACAGCACCTCTAAATCCCGAAGGCTCACAGGGTGTTAAATCTGAATCCATGAATATAGACGCTACGGAAAAGAAAGGAGCGGGTGAGGGAGTTCATGCTACAGGAACAAAACGACCAGCTGGAGAATCAGGAGAGGACGAAAAGTCTGCAGCGAAATGGCCCAAAATGACTGCACCTGAGACAAGCTCATTTTCCAAAAGTCCAGTTCTCGTTGCGGCGCTTCAATCCGATAGCAACATTTCTGAACCTGGTCCAAGCACTTCTGGTATTCGAAAGATGGAAACTATGACTGGATTCACTCCAGGAGTCCGTTTAGAGGCCCAAGATTTCGATGGAGTGTGGCACAATGCCCGTATTATTGAAGTGGACAACGATGATCGAGAAGTGCTTATTCGTTTAGACAAATCTAGCAAGACCAAGGGAGCTAgTGGTGTGGAAGAATGGATTCCAATGAATAGTAGCCGCTTGCGACAGAAAGCGTTCCCACCAACAAGTTCTTCAAAAGCGTTTATTTTGGGTGAAAAATGTCTAGCGCGCTGGAGTGGCTCAAGGCGGTTCCCCGCAACAATAAGCAAAATCCTTCCGAATGATATGTACGAAGTTTTATTTGATGATGGCTATGTTAAAGTGGTTAAAGGGAATCacataagtaaaataaagccTCCATCAGAGAAAGTCAAATCGGGGAGTTCTGGGAAGAATAAACAGCCCGCTAAAAAGGATTGGCCGTTAATATCTATGAGCTCTCTGAATTTGGAGGAATTAAATCTCCCAGTAATTCCAAAAGATGGAGAATGGTGCTGCCACTGGGTAAATGATCAGCCCATAGGGAAAGAAGGATTCCTCAATGTAGGAGATTACAAAAAACCGACAGTAATTGTAGAAGATTGGAGGCTACCACCAAATTGGACAAAGCATATGTATCAACGATCGAATGTATTGGGAAAATGGGATGTTATTCTCGTTAATCCGCAAGGAAAACGATTTCGGTCTAAAGCTGATTTGAAGCAATTCATTGAAGATCAGGGACAAGTTTACAATCCAGACATCTATGATTTCAGCATACACAGACGTCGTGCTAAAGATATTGGTGCATATGCCCATACGAAGGATTATAAGCCTCCTTCAACCCAACCGGCTGAGACCACCGCTACAGTTACTGCTCCTGTAGTTTCGACTGTTACTGCACCGCAACTTCCACCGATAGTTATACCACAAGTCACTCCTTTTGTTGAGGCTATACCTTCTCCATTGATTAAAACTGTAGAAGAAGGAATTCCCCCGCTGGAAGATGGCTATGtTTACGTGGGCAGCCTTAAGGTGCAAATAATTGATAACTTGTTTCGATGTCCGCATTTGGGttgtaacaaaaatttccggAAGGAGAACCACTTGCAAATTCACATCAAGCACTATCATGAAGATATCGCTAAaTCGCTGGGTGTTTGCCCTAATATGCAGGATTTGGCATGCAAACGTACCATAGGCACACCAGTCGAAGAACCACTTCCTAAAAATCACTTGTCAAATGCTCAATTCTTCGCAAAACTTCATCAACAGGACATGCAACTGCGAACGAACAGAAAATCAACGTCAACTATCATTAGTGCTCCAGTTTCGACCCCATCTCCCAATGCTTTACTTGACTCCTCAGAGGTGCTTACTTCTCCAGCAATTTTAGAGGAATCAAACCCAAAAATCCCCGAAGCTCAGGCGGCCCCTCCTCTTGAAGCAGTACCTCCTAACTTGGTAACTTCAGAAACTACGTCGTCCGCAATCAGCAAAGGATCTACATCACCAAATCCTTATCCGCATTCAACTGGGGACGACAGTTTTGTTCTTGACGAACCTCCTAAGTCACAGTCAAAACCCAAAAAAGCTCCGGATAGCAATCGACGAAGCTCTCGccaaaaaattactaaaaagtATCTCACATCGAATGCGTTAGATTCCAATCTTGTTGTGGCCGACCCGGAGGAAACTCGTCACTCATTCAATGCTACACCAGAGCAGAAACCTTCGGTAAAAAAATCGAAGCAATCAATTCAATTACCTGCAATTGCAGGTACGGCAGCGGGGGATTCAAATCAAGATGCAACGAGCCATACAACCGGCAGTTTGCCGGAGAACAGCCAAAGTCCAAAGTATATAAACGAGAACGGCGAAATTATTAAGATCGTTAGAATGAAGCAGGAGGAGATCATCAACTGTCTTTGTTCTTATGCTGAAGAAGACGGGCTCATGATCCAGTGTGAGCTATGTTTATGTTGGCAACATGGAATCTGCAACGGCATTGAAAAGGAAAGCCAGGTGCCCGATAAGTATATTTGTTACATTTGTCGTAATCCACAGCGAGGAAGATCGAGTCTTAAGTACATTCACGATCAGGACTGGCTATATGATGGTAAACTACCAGTCGCCAGCTACCACGCCCAGTCTCCTGCCCTCGATGAGCGGTTTGAGTTGTTGAAAAAAACTCATACACTCACAGGAAATTTGCTTGAGCTGAAGAGATTTCTGCATTCTTTAAGGGTTAAGATCAATGTTGCTGAAAATAAAGATCACCCAAAAATGTATCTTTGGGCGAAGAAATGGGAATCGTCTCCAATTAAGGAATCTAATAGTGAAGATGCATTGTCTGGGGAAGTGAAGGTTGATTCAACAGAAGTAAAACCAGAAGATGTGAGAAAGGAAGAGAATGATAAAGGAAATGCAAAAACTGAGTCAATTAATATATCTACAGCTGGAGAAAAGTCTAACCAAAGAGAAAGCCATAAGGAAGCTTCTGGGAGCAGTGTGAAGTATCGCCAACCAACAATTCCACAACCAGAAACTCCTATCAAGCCAGCAGAATGTCAATATCGCCTCCTTGATCACATTCAAAAGCAGCAGTCAGCCGTAATGGATTGCCTACAAAACATTGAATCACAAATAATGGagaTCGAATCTCTGGATAATAATGATTTGGACAGCGATGACTGCTCAAAAGCAAGAGAAACTCTATCATTGCTTATCAGGGATTTAGAGatcatgaaaaatattgctaaAATTAACACTGCCACCCCTTTCGTatcgtaa
- Protein Sequence
- MTRKCVIEGCTSKSGKPQYRGVTFHSFPFDSKTREKWIINCHLPADKNITKSVLVCSRHFRRADFQPMKSNKYLLKQGAMPTIFPWGKLDYVEPAISTAPLNPEGSQGVKSESMNIDATEKKGAGEGVHATGTKRPAGESGEDEKSAAKWPKMTAPETSSFSKSPVLVAALQSDSNISEPGPSTSGIRKMETMTGFTPGVRLEAQDFDGVWHNARIIEVDNDDREVLIRLDKSSKTKGASGVEEWIPMNSSRLRQKAFPPTSSSKAFILGEKCLARWSGSRRFPATISKILPNDMYEVLFDDGYVKVVKGNHISKIKPPSEKVKSGSSGKNKQPAKKDWPLISMSSLNLEELNLPVIPKDGEWCCHWVNDQPIGKEGFLNVGDYKKPTVIVEDWRLPPNWTKHMYQRSNVLGKWDVILVNPQGKRFRSKADLKQFIEDQGQVYNPDIYDFSIHRRRAKDIGAYAHTKDYKPPSTQPAETTATVTAPVVSTVTAPQLPPIVIPQVTPFVEAIPSPLIKTVEEGIPPLEDGYVYVGSLKVQIIDNLFRCPHLGCNKNFRKENHLQIHIKHYHEDIAKSLGVCPNMQDLACKRTIGTPVEEPLPKNHLSNAQFFAKLHQQDMQLRTNRKSTSTIISAPVSTPSPNALLDSSEVLTSPAILEESNPKIPEAQAAPPLEAVPPNLVTSETTSSAISKGSTSPNPYPHSTGDDSFVLDEPPKSQSKPKKAPDSNRRSSRQKITKKYLTSNALDSNLVVADPEETRHSFNATPEQKPSVKKSKQSIQLPAIAGTAAGDSNQDATSHTTGSLPENSQSPKYINENGEIIKIVRMKQEEIINCLCSYAEEDGLMIQCELCLCWQHGICNGIEKESQVPDKYICYICRNPQRGRSSLKYIHDQDWLYDGKLPVASYHAQSPALDERFELLKKTHTLTGNLLELKRFLHSLRVKINVAENKDHPKMYLWAKKWESSPIKESNSEDALSGEVKVDSTEVKPEDVRKEENDKGNAKTESINISTAGEKSNQRESHKEASGSSVKYRQPTIPQPETPIKPAECQYRLLDHIQKQQSAVMDCLQNIESQIMEIESLDNNDLDSDDCSKARETLSLLIRDLEIMKNIAKINTATPFVS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01183879;
- 90% Identity
- iTF_01461213;
- 80% Identity
- iTF_01461213;