Basic Information

Insect: Tipula vernalis
Gene Symbol: egg_1
Assembly: GCA_958295665.1
Location: OY282558.1:334989362-334997581[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4e-13 1.1e-08 37.9 0.0 6 75 1329 1391 1327 1393 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4e-13	1.1e-08	37.9	0.0	6	75	1329	1391	1327	1393	0.89

Sequence Information

Coding Sequence: ATGGCGAAATCCGGTGCAGAACGCATGAGAGAGTACCGCGCACGACAACGAGCTTTGGATGCTTTAAAATTAGCTGCAGCGAAATTGCACTTCAAATCAACTAATAGCGATTCTGCGAATCCAGCTGGGCCATCAACCAGCGAGCATGTGTCAACGATTGCTGTAGTCAATGTAAATTGGATGGGTAACAATAATACAACATCAAAAGTAATCGAAATTAGTGATTCGGACAATGATGACGAAAGTCCGCCGCAACCGAAGGAGAAAACAACGGAAGCGATTGTCGAAGCTTTACCTTGCGAAAAAAAATCACCCGTTCTACCTGTAACTGAggacaaatttaatattattattgattcggATGATGAAGTTGATACTCCACCAATTAAAAGTGACCAACTCGAAGAACATTTGGAAACTTCAAAAACTTACTATCCACCTGagtttattaatattgaatcattaaataaaattgaaccgAAAACCTCAACTTCACAACCAGAAACAACGAAGGttgataaaaatgttaataaatccAAACCTGATACGGTCATTGAAAAAATTGGTGACGTAAAAATAATTGAACTCCTGGATGATCCAATGGAAATAGATGAAATTAAAGAGGATGAAAAAGATGAGCAAGCTCCGAACGCTGCCACAATGGTTCTAGCAGATGAACAAAAAGAAGAACCCGAAATTATTGATCTGGATCAAAATGATGcaaatgaatttgttgaagaGTCCAAAGCAAAAGACACAGTAACtgatttaaaatgtaatgatAAAATGCCTAACACCATGAATTTAGAGAAGAAAAGTGTTCATGAAATATCTAAAGATGACAAAAATGATAAAGAAAAGGACGAAGTTGAAGTTGTTATTTTGGATAAAAATGATGTCAACAATCAAGATGAAGCGGCTCCAAGGACAGAGGAAGATGATCTTAAGACCATGTCAAGTGAGGCTCTTACTACACTTGTTAGTGAAATTATTCCGATGACAACGACGACGGATGACCTGACTTATGAAAATAATGCTgcggtgaaaaaaaaaattgaagaagaaaTTATCGATCTAGATGATAGTGGAGATTCTGATGCATTGGCTGatgaaaaaaatggaaaggCTGCGACATTACAAGAATTggtaaaagatttaaatttagaaggcACTAAAACAAACGTAGAAGACAGTCCTGTTTCCCAATCAGCCAATGAGAGTAATTCGAAAATAGTTAATACGGACGTTCCAGTACAAGATGACGAAAATATTGAATCTGACAACGCCATTGCTCAAGAACATATCGTCAATTTAGATAATAATATTGCTGCCGAAGCTCCATCGATCGAGCAAAATGTGAACGCTGCAAATACAgagaaattggtaaatattgaaGTTGGCAATAGCCATGCTGAAGAAGAAGTGATAGATCTAGATGCTAATGACAACGAAACTATCGAAGTACCACTTCATGataattctgaaaatgtaaACCAAATTAGTGAAAATACTAagaaagaagaaaatattttaccagAGAAGAACATTGAAACTGAATTATGTGATAAATACCCTGATACAGCACAGCCAAAACAAGATGAAGAGGAGATTATTTGTCTGGACGATAATGATACTGATGAGAATAAAGCAGAGGAAAAACAACCTGATTGCAAAATAGACTTAAAACTAGCTATTGAAACTGTAGAAAAAGATAATAAAGATGCCACCAATAAAGTTAATATAGAGCAGGTTAACGAAGTTCAGCCAAGCGAAGTTGCGATGGAATTAGATGCATGCCAAACAGAAACTGATGTTATTGATTTAGATCTCGACAATAACGACGGTGAAATCAATATCGCTACACAAGTTAATCCAGAGATTAATTTGAACGAAAACCAAGGTACTGcagatattgaaaataatttagaaaacatgACTTTAGACAATCAGTCGAATCTTATGGAAACGGAAGTTGAATTGGAAGAACAACAAGAAAAGAGCATTGAAATTAGTGTTCTGAGCAACAAGGACAATCAATTAGAAAAGAGTAACAAAATTGAAACAGAAAGTGATGGGTCGGCTGTTGTAAACAAATTGGACACAAAAATGGATGTTGACGATATGGAGGCCAACCAAACTGTTGATGAAGTGGTCAACCAAACTGTTAAAGATATTGTTGTCAACCAAACAATTGAGAATATTGTGGTAAaccaaattgttccaaatgaaacaggcaccaaaaaaattgttgaagataTTGCGGACAATCCATTGCAAGAATGTGTAAACTATCATTGCTGTAGAACAACAAGTAAAACATCTCCAGCTCCAATATTCGTATTGAGTTTCtatcgaataaataaaaaatcgaataaacgTCAATTTGTTTGCGAGAAATGTTATGACGATTGTGTGGAACAATACGAGCAAATGACTGGCGACATCATTGCTCACCAACCAATCgtatttaaaccaaaatctcAACCTGATTTGATAGAGCTTTCTGACTCGGATGATGATGATGCAAGCGGTAGTGCCGTCAGAAGGAAAACTCCAGGTTTGAATAaacatttaagttttattgaggATAACGAGAGTAATCGGAATGCGCTTGGAAATTTGGAAGATCTCATCGAAAAGgctttttctcaaataaatattgatttgcaATTAAAGAAACGAACCGATATTATTAACAGAACCATAGAGAAAAACGAAGcCACATCAACAGCCCTTTTTAACGATATAAGGGAACTTCAAAAAAGTGCCGATAAAATGCATTTTACTTTGTACCAGAAATATCCAAACCGTATTATTAAAGAACTCCCACCAATTGATTTAAACAAAgaagataaattgaatttaccaCCATTAGGCGATATAAGCTATCCACAAATTCAAGTTGGTAAAAAATATCTAGCGCCCAGGCATGCTATTAGCGGGGCTTGGGTTGAGTGTGAAGCATTGGAAGCTGTGTCTAATCATACTTCTGATGTCCGGAAACATGGTACACATACACACTGGAGAGTAATGTTTTGTCGTCGAGCAACTAAATTAGTACTAAACATAAAGCATATTGCTTATAGCGTTCCACCTGATGTACGTTTAAATGTGGGCACCCGAGTCGTTGCCATATTCCAGCAGGTCCCAGTTCCGAAACAATCATTTTTTCCGGGTACTGTGGGTGAAACTTTAAAGGACTCTAACAAATATCGatatcttatattttttgatgatgGTTACTGCCAATATGTAAAACATGAACATGTTCGGTTAATTTGCGAAGTTTCAACTAATGTTTGGGAAGATATTGATGGAAATCCGGGAACAAGTCGTTTCATTCAGGAATTTTTAACACAGTTTTATAACCGTATATCGCGACCAATGCTTTTAGCAAAACGAGGCCAAAAAATTGTCACTGAATTTAATGGAATATGGAAGCTATCAAAGGTTGTGGATGTGGATTGTaatctaataaaaatgtatatcgaaaaaaatcaGACGTTCGAATGGATTTACCGTGGTTCAAGTCGATTTGCGCCAATATTTAAACACCGTCAAATCGGAAGTGATCTTCAACTGAATGCTATAAATTACCATTTGAAGAAACGCAATGAACCATATATTGAAATGACGCTGGATGAAATTTCAGATCCAGGCTATCAAAGTGCTGATAACAATCGCATAGCAGAAATTACAAATGATTCAAAAGGTCTTGATCATCCTACTGCCACTCGTGCAGTGGCCCGAAAGAGTACGAATAATCAAGGTTCGAAAAGTTATATGAACAGTAATAATGGTGCGGTGAATAAAGCACCCGTTTACTTGAATAATTCTGTCATAGTTGTAGATGATGACAAAATGCCGAAAGGCAAAGTTACTTACTACGAGACGACAAAGAGATACTCAACAACTACATATATTGCTCACAAATGTACTCCGGCGTGTTTAGTACGAGTAGAAGATAATTTAGAACCGTTTAATCCGATAGCACGCCCTCTTCTCAGTGGATGGGAgagacaaatttgtaaatacaaGAGTCGTAAGATTGCAATTTATCGAGCTCCTTGCGGCCGTCGTTTACGAACTATGTTAGAAGTTCACCGATATTTAAGATTAACTGACAGTCCATTGAACGTTGAATGTTTTGATTATGACACAACAATGCATTGTTTAGCTGAATATACCGATTTGCCACAATTTATAAGAAATACCGATTTATCTGATGGAACAGAAAAAATGCCAATTTCTTGTTGTAACTATTTTGATAAGACAACACCACCAACATGTACGTATTCAACAAATCGAATACCTACGGAAggtgttgatttaaatttagacgAAGATTTTCTTTGTGCTTGTGATTGCAAGGATGATTGCATTGATAAATCCAAGTGTCAATGTTGGCAGTTGACTATAAAAGGAGCATGTTCTATTAATTCATCATTAACCGTTGACGACATTGGTTATTGTTTCAAACGATTATTGCATCCAGTACCAACGGGAATTTATGAATGTAATTCACGCtgtaaatgtaaacaaaattgtctGAATCGTGTTGTACAACATCCTCTAAGTGTCAAACTTCaagtatttaaaacaacaaatcgaGGTTGGGGATTGCGTACTCTACATGATATTCCTAAAGGGAGCTTCATTTGTATTTATGCAGGTGATTTGTTAACTGAACAATCGTCGAATGAACTGGGTGCCAAGGAAGGTGACGAGTATTTTGCCGAATTGGATTATATTGAAGCGGTAGAAGGTTTAAAGGAAGGTTATGAATCTGACATACCACGCGAAGAAGGAGACGAGGAACCAGAAGGCGAAAGGGATGATGATTTTGAAAACAGCGCTGATTCCGATGACGATGATTTTACGTCGAAATGTAAAGctttagataaaaaaataacaacgcGATCCAGCACTCGATTCGCTAAAAATCAAGACAGCAAAAAATCGAATACTTCAAACCGACCTCCTTCGACTCCTATTACAGTTCCTGTTACTGCATCAGCGGAAGATGATGATTGTATCACAATCAGTGATGACGAAGAAGTGCGAGCACCagttaattttattccaaatacaTCATATGACGATGATACTGAAGTTGATTCCAAATACAAATCAGTTCGTAAGCTATTCGGAAAAGACGAACTGGGCTATGTCATGGATGCCAAGCGCACCGGAAATATAGGACGCTATTTTAATCATTCTTGTAACCCGAATCTCTTTGTGCAAAATGTTTTTGTGGATACGCATGATTTACGATTCCCATGGGtaacatttttttcgaataCGTCAATTCAAGCAGGAACCGAATTGACATGGAACTATAATTATGACGTTGGTTGTGTACCAGGAAAAGTATTATATTGTCAATGTGATTCATCTAATTGTCGCGGGCgtttattataa
Protein Sequence: MAKSGAERMREYRARQRALDALKLAAAKLHFKSTNSDSANPAGPSTSEHVSTIAVVNVNWMGNNNTTSKVIEISDSDNDDESPPQPKEKTTEAIVEALPCEKKSPVLPVTEDKFNIIIDSDDEVDTPPIKSDQLEEHLETSKTYYPPEFINIESLNKIEPKTSTSQPETTKVDKNVNKSKPDTVIEKIGDVKIIELLDDPMEIDEIKEDEKDEQAPNAATMVLADEQKEEPEIIDLDQNDANEFVEESKAKDTVTDLKCNDKMPNTMNLEKKSVHEISKDDKNDKEKDEVEVVILDKNDVNNQDEAAPRTEEDDLKTMSSEALTTLVSEIIPMTTTTDDLTYENNAAVKKKIEEEIIDLDDSGDSDALADEKNGKAATLQELVKDLNLEGTKTNVEDSPVSQSANESNSKIVNTDVPVQDDENIESDNAIAQEHIVNLDNNIAAEAPSIEQNVNAANTEKLVNIEVGNSHAEEEVIDLDANDNETIEVPLHDNSENVNQISENTKKEENILPEKNIETELCDKYPDTAQPKQDEEEIICLDDNDTDENKAEEKQPDCKIDLKLAIETVEKDNKDATNKVNIEQVNEVQPSEVAMELDACQTETDVIDLDLDNNDGEINIATQVNPEINLNENQGTADIENNLENMTLDNQSNLMETEVELEEQQEKSIEISVLSNKDNQLEKSNKIETESDGSAVVNKLDTKMDVDDMEANQTVDEVVNQTVKDIVVNQTIENIVVNQIVPNETGTKKIVEDIADNPLQECVNYHCCRTTSKTSPAPIFVLSFYRINKKSNKRQFVCEKCYDDCVEQYEQMTGDIIAHQPIVFKPKSQPDLIELSDSDDDDASGSAVRRKTPGLNKHLSFIEDNESNRNALGNLEDLIEKAFSQINIDLQLKKRTDIINRTIEKNEATSTALFNDIRELQKSADKMHFTLYQKYPNRIIKELPPIDLNKEDKLNLPPLGDISYPQIQVGKKYLAPRHAISGAWVECEALEAVSNHTSDVRKHGTHTHWRVMFCRRATKLVLNIKHIAYSVPPDVRLNVGTRVVAIFQQVPVPKQSFFPGTVGETLKDSNKYRYLIFFDDGYCQYVKHEHVRLICEVSTNVWEDIDGNPGTSRFIQEFLTQFYNRISRPMLLAKRGQKIVTEFNGIWKLSKVVDVDCNLIKMYIEKNQTFEWIYRGSSRFAPIFKHRQIGSDLQLNAINYHLKKRNEPYIEMTLDEISDPGYQSADNNRIAEITNDSKGLDHPTATRAVARKSTNNQGSKSYMNSNNGAVNKAPVYLNNSVIVVDDDKMPKGKVTYYETTKRYSTTTYIAHKCTPACLVRVEDNLEPFNPIARPLLSGWERQICKYKSRKIAIYRAPCGRRLRTMLEVHRYLRLTDSPLNVECFDYDTTMHCLAEYTDLPQFIRNTDLSDGTEKMPISCCNYFDKTTPPTCTYSTNRIPTEGVDLNLDEDFLCACDCKDDCIDKSKCQCWQLTIKGACSINSSLTVDDIGYCFKRLLHPVPTGIYECNSRCKCKQNCLNRVVQHPLSVKLQVFKTTNRGWGLRTLHDIPKGSFICIYAGDLLTEQSSNELGAKEGDEYFAELDYIEAVEGLKEGYESDIPREEGDEEPEGERDDDFENSADSDDDDFTSKCKALDKKITTRSSTRFAKNQDSKKSNTSNRPPSTPITVPVTASAEDDDCITISDDEEVRAPVNFIPNTSYDDDTEVDSKYKSVRKLFGKDELGYVMDAKRTGNIGRYFNHSCNPNLFVQNVFVDTHDLRFPWVTFFSNTSIQAGTELTWNYNYDVGCVPGKVLYCQCDSSNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01455767;
90% Identity: iTF_01455767;
80% Identity: -