Tlat031210.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Tipula lateralis
Gene Symbol
MBD-R2
Assembly
GCA_963932295.1
Location
OZ010738.1:155246898-155250429[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.8e-12 2.1e-08 34.7 0.0 3 75 391 461 389 462 0.92

Sequence Information

Coding Sequence
ATGGGAGGCCGAAAGTGTTGTTTGGAGGCTTGTCCTTCGTCTTTGCCCCGGAGCAACGTACATGGAATAACATTTCATCGTTTTCCAATGAACCTGGCTAAACGTAAACGGTGGATCAAACAGTGTCGCGTACCAGAATCGATGAAAATAGTCAAAACTACTTTTATTTGTTCTTTGCATTTTAATAAGGACGATTTTCAGGAAGATAAAATGCCAAAAGCAATTTTAAGATCTTCGGCTTATCCTACACGATTTCCATGGGGTACATATAAATCCGAAGAACCGAATACGAGTGGTGAGATAGGCGATGAAGAATTAAAAATGAGTGATGATGAAGGTATAACAcctttgaaaaatgaaaatttaaacaaaactccGGTTAAGTCACCTGCGAAACGGTCAGCCAGTGCAGAAGAGTATATTACCGAACCAGCTAAGAAAGTCATTCGAAAAACATCAGATTCAGCTATTCTAAATACAAATGTGATAATAACTTCACCTAAAAAGGAagttgatttattgaaaacatCACCAAAATTTGAACGAGTTCAAAATTTTACACCTGGAACCAAAATAGAAGCGCaagattttaataaatcatgGCATTCGGCCAAAATTGTCGAAGTCGATTCAGATGATCGAGAAGTGTTGGTGCACTTTGAAACCAGTTTAAAAGGTAAAACACCAAGTAATATCGACGAATGGATTTCAATGGATAGTAGTCGTTTACGCCCAATTCAGTTAAAACCTTCACCAATTAAAAAGGCGCCCAATTTTGCAATTGGTGAGAAGTGCCTTGCTCGATGGAGTGATTGCAGAAAATTTCCCGGCACTGTAAAAGCAATACTACCAGATAATAATTTCGAAATTCTATTTGATGATGGGTATACAAAAATTGTAAAGAGTTCccatatgaataaattaaaaaaagggtTAGTAAATAAACTGTCGATGCAAACAAAGCCGGTGCAAACAGAAGTGGTACAAAAAGTACAAACGGCAATGCTATCACCTAGACAAGTCGAGACTCCAATTAAATTAGAACGAGCCCCTATAGTGTGGGATAATATACCCGAACAACCAGAAGGTGAGTGGGCTTGTCATTGGTTTAACGATGGACCAGTTGGGCAGGAATCCACTTTACTGTATTCAGAAGGTCGcctaattaaaactattatagtGCGAGATAATCGCTTGCCGGACGGTTGGATTAAACATATATTTCAACGATCGGGTTTACTTGGCAAATGGGATATAATACTCGAAACACCAACTGGAAAAGTATATCGAAGTAAAATGGAAATGAAACTGCACTACGATGAAATAGGAAAAATTTTTGATCCAACTATCTTTGATTTTAGTCTACATAAGCGTCGAGCCAAAGAGCTGGGTCTTTGTAAATATTCCCCAGATTATTTTGCAACAGCTCATATTCAGATTCCAATTCCAGCCAAAAAGGTTAAAAACGATCATAATGTTGAAGTGCCCATTGTGACTGACTCTGATCCTAGTGTTGTGGTAGAAAAGAAGGAGGTCTTGAATGAAGATTTTATAATGCTCGGATCGGTAAAAGTTAAAATCATTGATAATTTGTTAAGATGTCCGGGTTGTGATAAGAATTTTCGCAAGGAGAACCATCTACAAATTCACATTAAGCACTATCACAAAGAGTTGAGCGAATATTTAGGCGTTTGTCCAAATATGACAGATCTGGCTTATTTAAGGACAGTCGGAAATACATCAACGGAAGAAACATTGCCGAAGAATCACCTTCCAAATAAACAGTTTTTTGAAAAGGTTCATCAGCATGATATTTTATCTAAGACATCAAGAAAATCACATTCGTTTACGTTACACGATGAAACACCATTGTCAGATGGGCATGTTGATATAAATGATACAAAAATGCCCATAGATTTGCTTAGTACACCAGTATCGTCCAAGGATACAAATAAGGTTAATTTGAATTTAGATGATGCTAAGAAGAAATTTACACTTTTGGAGGAAGCTTTAAACAGTCAATCTGTTATGGATAAACCAACTCAGCTAATTTCAGCAGAAACACCAATTCAAACTATGAAAGTGGACGAACCTGTCTCACAGACCAGTATGGCTAATATACCATGTGATAATAAACAGGATCTTGCCGATCCGGAGCTGTTTATTAAAAGTCATTCGGTTTCAAAATCGAgtggatttaaaattaaaaccaaatttggaTTTACTGCTCGCAAGAAGGTACCAAAACTACGCACAAATATAGCCAAAATGCGTGTGAAGCAAACCCAACGTCTTGAGGCGCCTACTGCACTCAACGAGAGTTTTACCGAATACGACGAAACAAGACATTCGTTTGGTAGTCCCGATGTTGcatttaaacgtcaaaaattaaCGAATCAAAGCATGTTCGCTGATTCAGGTCAAGATAcaaattctcaaaataattcGAGCATCGCCGAAACAAGCCAAAGtcccaaatatataaatgaagatGGTGAGGTAATCAAAATTGTAAGAATGCGCCAGGAAGAGATCATAAATTGTATTTGTACATTCCACGAAGAGGACGGATTGATGATCCAGTGTGAGTTGTGTTTGTGTTGGCAGCATGGACTTTGTAATGGTATCGAACGAGAAAGTGAAGTtccagaaaaatatatttgttatatttgtcgGAATCCAACCAAAGGACGTAATTCATTGAAATATAAGCATGATCAGGAATGGTTGTACGAAGGCCGGTTGCCATCTCTCATCAAGCAACCGAATTTAAAACGAGAAAATCGTTATCATTTGTTGAAACAGAGCCATACGCTTTCGGGTAATCTATTGGAACTGAAAGGTTTTCTACATAGTCTTAAAGTGAAAATCAATATTGCCGAGAAGAAAGATCatccaaaaatgtatttatggTCGAAGAAATGGGAGTCCTCGCCAACTCGATCGGAAATGATGGGAATCTCACCGTTgaatagaattaaaaaattcagtGAAATaccgaaaatcgaaaattgtgaTGAAAAGCCTggaaatttagaattaaatcaGCTTTTTTCGCCACAAATGGAAACTCCTAAAAAGGAGGATTGCAAAAGTcaattttattcgaatttaaTGCAGTCGCCAAGCGAATTAAACAAAGAATCTCCATCAcccaaaatcgaaaatcaaggACCAGCAATGCCGAATATTCCACAACCTGAGGCTGCTATAGATCCAGCCGAATGTCAACTACGTCTTTTGGAACACATACAAAAGCAACAGAATGCAGCTATGACACGTTTACAAAATATTGAAGAGCAACTTACGAAAATCGAATCCGTAGACGAAACTTCAgataaattggaaaatgaaaaCTTTACAAGAACCAAGCAAACAATTCAAATGTTGATACGTGATTTAACAACAATGAGAAAAATTGCAACAACAAATTGCAGCGACATGTATGGCGGATCATATAAAATTGCGTAG
Protein Sequence
MGGRKCCLEACPSSLPRSNVHGITFHRFPMNLAKRKRWIKQCRVPESMKIVKTTFICSLHFNKDDFQEDKMPKAILRSSAYPTRFPWGTYKSEEPNTSGEIGDEELKMSDDEGITPLKNENLNKTPVKSPAKRSASAEEYITEPAKKVIRKTSDSAILNTNVIITSPKKEVDLLKTSPKFERVQNFTPGTKIEAQDFNKSWHSAKIVEVDSDDREVLVHFETSLKGKTPSNIDEWISMDSSRLRPIQLKPSPIKKAPNFAIGEKCLARWSDCRKFPGTVKAILPDNNFEILFDDGYTKIVKSSHMNKLKKGLVNKLSMQTKPVQTEVVQKVQTAMLSPRQVETPIKLERAPIVWDNIPEQPEGEWACHWFNDGPVGQESTLLYSEGRLIKTIIVRDNRLPDGWIKHIFQRSGLLGKWDIILETPTGKVYRSKMEMKLHYDEIGKIFDPTIFDFSLHKRRAKELGLCKYSPDYFATAHIQIPIPAKKVKNDHNVEVPIVTDSDPSVVVEKKEVLNEDFIMLGSVKVKIIDNLLRCPGCDKNFRKENHLQIHIKHYHKELSEYLGVCPNMTDLAYLRTVGNTSTEETLPKNHLPNKQFFEKVHQHDILSKTSRKSHSFTLHDETPLSDGHVDINDTKMPIDLLSTPVSSKDTNKVNLNLDDAKKKFTLLEEALNSQSVMDKPTQLISAETPIQTMKVDEPVSQTSMANIPCDNKQDLADPELFIKSHSVSKSSGFKIKTKFGFTARKKVPKLRTNIAKMRVKQTQRLEAPTALNESFTEYDETRHSFGSPDVAFKRQKLTNQSMFADSGQDTNSQNNSSIAETSQSPKYINEDGEVIKIVRMRQEEIINCICTFHEEDGLMIQCELCLCWQHGLCNGIERESEVPEKYICYICRNPTKGRNSLKYKHDQEWLYEGRLPSLIKQPNLKRENRYHLLKQSHTLSGNLLELKGFLHSLKVKINIAEKKDHPKMYLWSKKWESSPTRSEMMGISPLNRIKKFSEIPKIENCDEKPGNLELNQLFSPQMETPKKEDCKSQFYSNLMQSPSELNKESPSPKIENQGPAMPNIPQPEAAIDPAECQLRLLEHIQKQQNAAMTRLQNIEEQLTKIESVDETSDKLENENFTRTKQTIQMLIRDLTTMRKIATTNCSDMYGGSYKIA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01458394;
90% Identity
iTF_01457424;
80% Identity
iTF_01457424;