Tfem005219.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Tiphia femorata
Gene Symbol
lz
Assembly
GCA_944319705.1
Location
CALUEQ010000109.1:250276-265964[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.3e-73 1.1e-69 232.1 0.0 4 129 106 231 103 231 0.98

Sequence Information

Coding Sequence
ATGGATATATTCGGCCGTTGCAACGGCGGCGGCGGTGGAAGCAGCACGACGGTAACCGGAAGTGGATCCAGCTCGACTAGGGCTACCAACAACAACGAGTCCTCGAGTGGCACGGCTAGCGGCGGAGGCGGAAGCGGAGGAGGAGCGGCAGGAGGCGGCGGTGCCGGTGAGAACGCTGGAGCTGGCGGCAGGATGCAGTTGACAGGAGCCTCGGCTCCTGGCGCCGCTGCATCGCCGGAGTCCGGCGTCTCGCCGTTAACCGATGCGTACACCAAGATGACAAGCGACATACTAGCGGAGAGAACGTTGGGAGACTTCGTCAGCGAACATCCGGGGGAGCTCGTTAGAACCGGCTCTCCTCACCTAGTCTGCACGGTGCTACCGGCGcactggagatccaacaagacgttaccggtggcgttcaaggtcgtagcattgggcgaagttggcgacggcaccctggtgaccgtacgcgctggcaacgacgagaactgttgcgcggaactgagaaattccacggccctgatgaagaatcaagtggccaagttcaacgaccttaggttcgtcggtagaagtggaagagGGAAAAGCTTCACCCTGACGATAACCGTATCGACGACGCCACCCCAGGTGGCCACCTATTCGAAGGCGATCAAGGTGACGGTGGACGGGCCGCGTGAGCCGAGATCCAAGACCAGTGAGTATCACTGGCAGCAACAGCAGTTCCACGCGTTCGCCTTCGCCTCTCAGCGCGGTGGACCGTTTTTCGCCTCGCCCCTGGTGGATCCGCTGCAGCCACTTCCAAACCCGCTGCAACCTCTGCCGAATCCTTTGCAACCGCGGGACCCACTGTCGTCCTTCAGGCACGCGATGCCCGGCAACTGTCAGAACATGTCCCAGTTTGGTCTGACTGCGGGTAACTCCTGGGGATACGGAAGTACGGCTGGTTACGCCGGTTACCTTCCCGGTCCGCTCTCGTCGTGCGCGGCACAGGCGTCCTTTCCGCCGCCTCCACCGCCGCCACCACCACCGCCTCCGCCACCTTCCTCGTCGTTGGCGCCGTTCGCCGGTACTGCCTCGATGACCACGCCTACGGCGCCGGACTCCACGGCGGGCTCCACCGTCACTTCCGGTACCACGGGCACCACGCCGCAGCAGGACGCTTTCTCCGCGGTCTCCTCTCTTGTGCCGGACACCACGACGCCCGGACAATCGGACCCCTTGGATCCTTTGAGCAGCCTGATGTCCGGCACCACCTCTCAGAGGTACCAGGAGTACGTGTCCCCAAGGTCCTTGTCCACGGACTCGAGTACCACGGAGAGCCCGGTCCACGAGGAGCAAGGATTCGGCCAGAACTACGGCAACTACTTCCCCACGCCTGGCGTTCTACCTAGCATACTCTACTCCCAGCTCTACGGGAATCAGTTTCAGAATTCCGAGAGCCCGGAGCAGAGGGCGGTCACCGAGAGCTGCAGCGTCAGGCAGGAAGAGGTCAGGCCCGACAACAACGTTTGGCGACCTTACTGA
Protein Sequence
MDIFGRCNGGGGGSSTTVTGSGSSSTRATNNNESSSGTASGGGGSGGGAAGGGGAGENAGAGGRMQLTGASAPGAAASPESGVSPLTDAYTKMTSDILAERTLGDFVSEHPGELVRTGSPHLVCTVLPAHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTTPPQVATYSKAIKVTVDGPREPRSKTSEYHWQQQQFHAFAFASQRGGPFFASPLVDPLQPLPNPLQPLPNPLQPRDPLSSFRHAMPGNCQNMSQFGLTAGNSWGYGSTAGYAGYLPGPLSSCAAQASFPPPPPPPPPPPPPPSSSLAPFAGTASMTTPTAPDSTAGSTVTSGTTGTTPQQDAFSAVSSLVPDTTTPGQSDPLDPLSSLMSGTTSQRYQEYVSPRSLSTDSSTTESPVHEEQGFGQNYGNYFPTPGVLPSILYSQLYGNQFQNSESPEQRAVTESCSVRQEEVRPDNNVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00738113; iTF_00770146; iTF_01198439; iTF_01199178; iTF_01394900; iTF_01130584; iTF_00769411; iTF_00452369; iTF_01086997; iTF_01120003; iTF_00773572; iTF_01057412; iTF_00085063; iTF_00084309; iTF_00085943; iTF_00087710; iTF_00086879; iTF_00862346; iTF_01122861; iTF_01122212; iTF_01394061; iTF_00200529; iTF_01234800; iTF_01232201; iTF_01492657; iTF_01493359; iTF_00306034; iTF_00729842; iTF_00059956; iTF_01199916; iTF_01412082; iTF_00174797; iTF_01411252; iTF_01048029; iTF_01413929; iTF_01303083; iTF_00175539; iTF_01207124; iTF_01001861; iTF_00262438; iTF_00342920; iTF_00905192; iTF_00996111; iTF_00059221; iTF_01560214; iTF_00058455; iTF_00414076; iTF_00721024; iTF_00265447; iTF_00263142; iTF_01378985; iTF_00397834; iTF_00397050; iTF_00840827; iTF_00996812; iTF_00798352; iTF_00266229; iTF_01298933; iTF_01306166; iTF_00459517; iTF_01508638; iTF_01255316; iTF_01056567; iTF_01055746; iTF_00439239; iTF_00828551; iTF_00829257; iTF_00982744; iTF_00861667; iTF_00864419; iTF_00865103; iTF_00183077; iTF_01066726; iTF_01068755; iTF_01070133; iTF_01067389; iTF_01068063; iTF_00965833; iTF_00860909; iTF_00684593; iTF_00863057; iTF_01065331; iTF_01424152; iTF_01069427; iTF_01066021; iTF_00183734; iTF_00962967; iTF_00964259; iTF_00961604; iTF_00863740; iTF_00963646; iTF_01232792; iTF_01513944; iTF_01513249; iTF_01512622; iTF_01233424; iTF_00860165; iTF_00359993; iTF_00625281; iTF_00760770; iTF_00223655; iTF_00222317; iTF_00214804; iTF_00222971; iTF_00228448; iTF_00214187; iTF_00232398; iTF_00233012; iTF_00216853; iTF_00231096; iTF_00219579; iTF_00225020; iTF_00231775; iTF_00683948; iTF_00140365; iTF_00216168; iTF_00142263; iTF_00141615; iTF_00221712; iTF_01070834; iTF_00117782; iTF_00230488; iTF_00181754; iTF_00015171; iTF_01477354; iTF_00181100; iTF_00015830; iTF_00264788; iTF_00141051; iTF_00633405; iTF_01475965; iTF_00292062; iTF_00295778; iTF_00297316; iTF_00254854; iTF_00292712; iTF_00254090; iTF_00291306; iTF_00252588; iTF_00293488; iTF_01472950; iTF_00298078; iTF_00251839; iTF_00294239; iTF_00295013; iTF_01473689; iTF_00296543; iTF_01475221; iTF_01474456; iTF_00253337; iTF_00391070; iTF_00451709; iTF_01392543; iTF_01389202; iTF_00754368;
90% Identity
iTF_01255316;
80% Identity
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