Basic Information

Insect: Rhogogaster chlorosoma
Gene Symbol: lz
Assembly: GCA_944452905.1
Location: CALYCC010000014.1:1941494-1955924[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.2e-73 3.7e-69 231.2 0.0 4 129 86 211 83 211 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.2e-73	3.7e-69	231.2	0.0	4	129	86	211	83	211	0.98

Sequence Information

Coding Sequence: ATGGATATATTCGGTCGTTGCAATAACGTCGGTGTTGGTGCTGGTGTCATTGTTGGTGGCATAGGTGGAAGTGGAGGAGCCCGTGCTACTGCAGGACTGGGGTCAGTCGGTGGTACCGGAAACAGTGGAGGAATGCAGTTGACGGGAGCTTCAGCCCCGGGGGCAGCGGCATCCCCGGAGTCCGGGGTGTCGCCGCTTGCCGACGCGTACACAAAGATGACAAGCGACATCCTCGCCGAGCGGACTCTTGGCGACTTCGTGACCGAGCACCCCGGCGAATTGGTCAGGACCGgttcaccgtacttcgtttgcaccgttcttcctgtgcactggaggtcgaacaagactctgcccgtagccttcaaggtagtagcgctgggcgaagtcggcgacggtaccctagtgacagtccgagctgggaacgacgagaattgttgtgcagagctcaggaactcgacagccctgatgaagaaccaggttgcgaagttcaacgatctaagattcgtgggtagaagcggaagggGAAAAAGTTTCACCTTGACGATAACGGTGTCTACGTCACCTCCACAGGTAGCGACGTATACCAAAGCCATCAAGGTGACTGTCGATGGACCACGAGAGCCGAGATCCAAGACCAGTGAGTATCACTTGCTGTCGCTTCTAGGGCAGCAGCAGCACCTTCACGCTTTCGCATTCGCCTCTCAACGCGGAGGACCATTCTTCACATCGCCACTGGTCGATCCTTTGCAACAGTTACCTAACCCTCTCCAGTCGTTGTCGAATCCTCTGCAGCCAAGGGATCCGCTGTCATCGTTCAGGCACGGGATGCCAGCCAACTGCCAAAATATGTCTCAGTTTGGATTGACGGCCACAAACTCCTGGGGATACGGCAGCACTACTGGATATGCTGGGTATCTACCGAGCCCGTTGTCTTCTTGTGCTGCTCAGGCTTCATTTCCACCGCCACCACCTCCACCACCGATTACCTCATTCACGGGGACAGCCTCGATGACCACCCCTACGGCACCCGATTCTACAGCAGGTTCGACGGTGGTAGCTGGTGCTACCAGCACGACACCTCAGCAGGACGCCTTCTCCACAGTTCCGTCTTTGGTACCAGATACGACGACGCCGACTCAATCCGACCCTCTAGACCCACTAAACACTCTGATGTCTGGTTCGACGCAGAGGTACCAGGACTACGTATCACCGAGGTCTTTATCTACGGACTCTAGCACCACCGAGAGTCCTGTTCATGAAGAAGGTTTCGGGCAAAATTATGGGAACTACTTTCCCACACCCGCAGGTGTACTGCCTAGCATTCTTTACTCCCAACTTTATACCAATCAGTTCCAGAACTCAGAGAATACGGAACAACGAGTCGTACCGGAAAGCTGTAGTGTAAGACAGGAGGAAGTTCGGCCTGATAATAACGTCTGGAGACCATACTAA
Protein Sequence: MDIFGRCNNVGVGAGVIVGGIGGSGGARATAGLGSVGGTGNSGGMQLTGASAPGAAASPESGVSPLADAYTKMTSDILAERTLGDFVTEHPGELVRTGSPYFVCTVLPVHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTSPPQVATYTKAIKVTVDGPREPRSKTSEYHLLSLLGQQQHLHAFAFASQRGGPFFTSPLVDPLQQLPNPLQSLSNPLQPRDPLSSFRHGMPANCQNMSQFGLTATNSWGYGSTTGYAGYLPSPLSSCAAQASFPPPPPPPPITSFTGTASMTTPTAPDSTAGSTVVAGATSTTPQQDAFSTVPSLVPDTTTPTQSDPLDPLNTLMSGSTQRYQDYVSPRSLSTDSSTTESPVHEEGFGQNYGNYFPTPAGVLPSILYSQLYTNQFQNSENTEQRVVPESCSVRQEEVRPDNNVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01453865;
90% Identity: iTF_01413929; iTF_01199916; iTF_01412082; iTF_00059956; iTF_00175539; iTF_00174797; iTF_01411252; iTF_01048029;
80% Identity: -