Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_905220615.1
Location
HG992312.1:3086925-3107643[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.5e-17 1.1e-13 50.9 0.0 6 67 620 680 617 689 0.92
2 3 0.86 3.7e+03 -2.1 0.0 6 28 902 923 898 949 0.82
3 3 2 8.8e+03 -3.3 0.0 29 44 997 1012 975 1014 0.78

Sequence Information

Coding Sequence
ATGGCTGTAAAAATCTGTTGTATAGAGAAATGTAAATCGTCAACATTGAGAAAGGAGGATGATGGTGTCACATATCATAAGTTTCCTAATGATTCCAAGCTCAAATTGGTCTGGTTAGAGTCTACAAAGGTTGTACAGAAAAATGACTTAAATCTTTATGTATGCTCCAGGCATTTCTGTAAACTTGATTATAAGTTATATATGGACACAAAGTATATATTAAGAGCAGATGCTGTGCCATCAATTTTCCCCTGGAACATGGAGGAGTCAACAGTAAATGATAGTAAAATGGAGCCAGATAATTTGCCAACAAAACCAGAGGATTTTGGAGAATTTGAATTAAATGTAAACAAATCTAAGCAAATAGGCACAGGGAACAATGTTTGTGATCCACCTACGATTCTACTTTCTTCAAATAATTCTCAAATAAGTAATGTTAAAGATAATGGTGAAAAAGAACAAAGTACGATGGCGTTATCAGTGGGATCGAAAGTAGAGGCCAAAAATTTTGGTGGTGTATGGTTTTCTGCCGAGATAGGGGAGGTGGATTATGATGAACTGGAAGTCCTCGTACAATATGACGACATCAAAAAGCAAGATGAGTGGATTAGTGTAAGTAGTCCTCGCTTACGACCATACATTGAGAAGCCAAAGATTCCTTCGTCGCCTATAAATGGTCCTTCGTTAAACTATAGCTTCGAAATGCCTCTGAACAAAAGAAAACTAAAGTTTAAGGTCGGGGAAAGGTGTTTGGCAAAATGGAATAATGGAAAATTCGTTGCTACTATACAGAAAGAACTTGATGATGATCAGTATGAAGTTATGTTTGATGATGGAGTATTGTTGACATGTAAATTTTCAAAATTATCTAAACTCAAACAAGTTAAAAATGAATTTGAACCACAACCATCTACCAGTTCTGCAGCATTCACCCAGCTTTCACCATCAAAAACTCACAGACACCTTTTTGATCCATCAAGGGACTATTTGGGAACAAAGAGTGAACGTAGGGAGAAGAAACGGAAATTAAATATTAAGGCTCTGTTTAATATTGGCCAAACAAAGCGGAAATTCTCAAAGACTCATAAACAAAATACAAAGATTATTAGTATGAAGAAAAGTGTAGCACCATCAGCATCAGATAAAGCGAACTTGACGAGGGATATAGAAATGATAGAGAGGGATAGCCCGGAGCCTGAATGTAAACTGGAGAACTTTGAACAGATAAATGAGGAGAAACATGAAGAGACATTGTGTCAAATAAAAGAGGTAATTATTAAATTAGAAAAAAGCCTTAGTCAGAATAACTCTGAAGTAGAAAGTGTGGCCTCGCCAATGCTCACAGAAATTAAGGAGGAATACGTTAAGGAGGAAGAAGTTGATAAGGAAGAAGTCGATAAGGAAAAAGTTGACAAGAAAGAAGTTGATAAGGAAAAAGTTGACAAGGAAGAAGTTGATAAAGAAGAAGTTGATCAGGAAGAAGTTGATCCGAAAGAAGCTAAACCTAAAGATGTAAAAGTTAAAATAGAAATTGATCAGTTGCCAGCCGGTGAGATAAAAAAAGAACCAATTAAATTGGTTATAAGTTTGCCACCAGATCAGAAGTTTAAGAAAATGAGTAAGATTAGGAGAGCTAAGAAGTTAAGGATGATAAGAGAGAAGATGGTTAAGGAAGAGATGGAGAAGGTTAAAAGTGAATTAGAAGAGATGAAGAGACAAGTTTTGGAAATGAAACAACAGAGCTACCTATTGCCAGGCGAATGGTGCTGCAAATGGGTTGGCAACCAACCAGAGGGCGTTGTTTATGAAAATGAGAGGATTGATCATTCTAAAACAGTGCAAAGGCTCGCTATACAGGTGTTTGATAAGAGATTACCATCTGGATGGATTAAATTGTTAGTGAGGAGATCTATTGGTACTTCAGCTGGTAAATGGGATGTGTCTTTTGTATGCCCAGACGGTCGTAAAATCCATACGAAATCCGAAATGAGAGCTTATTTAGAGCTACAAAACAATCCTGATTTGAAACCGTATGAGTATGCACTCTTAGACTTTGGTATACATCGGAAACTGTCCCGGAGACTCGGTTGGGATGATGAGATACCAGTTGTGCCCGTGACGCATAAATCTAAGAAAAAGAAACGTGACAGGTCTGGGGAACCATCACGTAAGAAGCAAAAGCTGTGTGCTATTCCAGTTACGATTGAGACAACTGTTAATACACCTGGATTAAATGAATCAAGCTTTGTTCCACCTGTATTTGATAATTCAACATGGAAAGATGGATATGTTTACGTGGGCTCATTGAGAGCGGAAGTGATAAACAACATGTTGCGTTGTCCAGCCCACGGTTGCTTCAAGAATTTCCGCACGAATATACTATTACAAATGCATATAAAGTATTATCACAAGGAATTGATCGCTCTCATGGGTAGCACGCCCAATGTCGTTGATTTGGCTTCGGCGAGGACAGCTACAGAACCAGATGTACAATTGAAGACCAAATCCAAGACCAAATCGAAGCAAACTAAACGTGTGGATAGTGAAGCTTATTCAGATGCCTTACAAAAGGAAATGGGTTATCTTAGATATGAAGTAGAGAAAATACCTACGTTAGAGTCTCCTAGGTTAAGAAAGGCTCTTGTTGGAAAACGTAAAAGACCCAAAGTCTTACTGCCAGTGCGGAAAGCGGAAACTGCTGAACCAAAGGAAATGGAAGCGGAGTGCAGTTTTAGAGAGGAGTTTGAGAGGAAGTTTGGTCCATCCGCTGAGTGTATGAAGGAACTTGACTTTGAAACTGAAATCTCAGCTCATACAGTCTCCAAATCTGGCGACGATAGAAAGAAGATGGAGAGGTTTGGTAAAGGTGGCGTGTCAACAGCGAGTGAAGAAGACGACTTTGGTTCTGATACAATGTCGAGTTACCAACGCTCGGCAAGTCCCGAAGGCAAACTGGACCTTCGACAGGACAGGTTACAGGATCGAACCAAGGAAGGCGAGTTGTATTATACTTCTGAAACTGGCGAAAGGATCAAGATAGTTCACATGAAGCGGGAGGAGATAATAAATTGCCATTGTGGATTTAGAGAGGAAGATGGTCTCATGATACAATGTGAATTATGTTTATGTTGGCAACATGCGCTGTGTCATAATATACAGAAGGAATCAGAGGTACCAGAAAAATACACATGCAGTATTTGTTTGAACCCACGCCGTGGGCGTCGATCTCGTCGTTTCGTCCATGATCAGGATCGCTTGTATGAGGGTTTGCTTCCTGGCGCGGCTCCATCACAGAACTTGCGGCGAGCACATGAACTATCAGGCAATTTGCTGCGTATTGCAGACGCTTTACATGCGCTACGGGTGCAGAGATATGTGGCCACGCAAAAATATCATCCCAAACTTCAGTTGTGGTCTACTGATTGGGAGAATGATGACATGGGTGACAAGTATGATGAATATGATCTAAATAGTATTATTAAGGAGGATTTAGCAGACATTAGACTGCCCGGTGATGATGACAAGGGATTGTCACAGAGATCTGATGGTAGTCACTCTTTGGCCAATTTATTGGATGGCTCGGGCACACCGTTCGATCTGCCAATATCATCAGACTTTGAAAGATTGGCCAAATCAGTGCAAGAAGTAGATCTTACGCATGCCGCCGATGCTGACATCCAGGACAGTACATGCAGACAGAGACTTTTATTACATGTGCAGAAGTGTCAAGCACGAATTGACGCCAGACTTGATTCTATTGAAGCACAAGTTGCAGAGTTAGAATCTCAAGACCCATCCCTGGTTGACGACGAAACAGCAGACTACTACCCACGCACAAAACAAACTATACAAATGATGTTACGCGATCTGGACACTATGGAGGAACTGGGCGTTATAACATAG
Protein Sequence
MAVKICCIEKCKSSTLRKEDDGVTYHKFPNDSKLKLVWLESTKVVQKNDLNLYVCSRHFCKLDYKLYMDTKYILRADAVPSIFPWNMEESTVNDSKMEPDNLPTKPEDFGEFELNVNKSKQIGTGNNVCDPPTILLSSNNSQISNVKDNGEKEQSTMALSVGSKVEAKNFGGVWFSAEIGEVDYDELEVLVQYDDIKKQDEWISVSSPRLRPYIEKPKIPSSPINGPSLNYSFEMPLNKRKLKFKVGERCLAKWNNGKFVATIQKELDDDQYEVMFDDGVLLTCKFSKLSKLKQVKNEFEPQPSTSSAAFTQLSPSKTHRHLFDPSRDYLGTKSERREKKRKLNIKALFNIGQTKRKFSKTHKQNTKIISMKKSVAPSASDKANLTRDIEMIERDSPEPECKLENFEQINEEKHEETLCQIKEVIIKLEKSLSQNNSEVESVASPMLTEIKEEYVKEEEVDKEEVDKEKVDKKEVDKEKVDKEEVDKEEVDQEEVDPKEAKPKDVKVKIEIDQLPAGEIKKEPIKLVISLPPDQKFKKMSKIRRAKKLRMIREKMVKEEMEKVKSELEEMKRQVLEMKQQSYLLPGEWCCKWVGNQPEGVVYENERIDHSKTVQRLAIQVFDKRLPSGWIKLLVRRSIGTSAGKWDVSFVCPDGRKIHTKSEMRAYLELQNNPDLKPYEYALLDFGIHRKLSRRLGWDDEIPVVPVTHKSKKKKRDRSGEPSRKKQKLCAIPVTIETTVNTPGLNESSFVPPVFDNSTWKDGYVYVGSLRAEVINNMLRCPAHGCFKNFRTNILLQMHIKYYHKELIALMGSTPNVVDLASARTATEPDVQLKTKSKTKSKQTKRVDSEAYSDALQKEMGYLRYEVEKIPTLESPRLRKALVGKRKRPKVLLPVRKAETAEPKEMEAECSFREEFERKFGPSAECMKELDFETEISAHTVSKSGDDRKKMERFGKGGVSTASEEDDFGSDTMSSYQRSASPEGKLDLRQDRLQDRTKEGELYYTSETGERIKIVHMKREEIINCHCGFREEDGLMIQCELCLCWQHALCHNIQKESEVPEKYTCSICLNPRRGRRSRRFVHDQDRLYEGLLPGAAPSQNLRRAHELSGNLLRIADALHALRVQRYVATQKYHPKLQLWSTDWENDDMGDKYDEYDLNSIIKEDLADIRLPGDDDKGLSQRSDGSHSLANLLDGSGTPFDLPISSDFERLAKSVQEVDLTHAADADIQDSTCRQRLLLHVQKCQARIDARLDSIEAQVAELESQDPSLVDDETADYYPRTKQTIQMMLRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01452398;
90% Identity
iTF_01452398;
80% Identity
iTF_01452398;