Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.4 4.3e+03 -0.8 0.0 32 49 2 19 1 22 0.84

2 10 0.0021 23 6.5 0.2 28 41 32 45 8 66 0.83

3 10 0.007 76 4.8 0.0 28 49 77 98 54 100 0.77

4 10 0.099 1.1e+03 1.1 0.0 28 46 111 129 108 135 0.85

5 10 0.048 5.3e+02 2.1 0.0 28 48 145 165 136 169 0.85

6 10 0.036 3.9e+02 2.6 0.0 28 48 179 199 156 203 0.75

7 10 0.051 5.5e+02 2.1 0.0 28 48 213 233 203 236 0.86

8 10 0.048 5.3e+02 2.1 0.0 28 48 247 267 228 271 0.82

9 10 0.031 3.3e+02 2.8 0.0 28 48 281 301 258 304 0.75

10 10 0.047 5.1e+02 2.2 0.0 28 48 315 335 293 338 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.4	4.3e+03	-0.8	0.0	32	49	2	19	1	22	0.84
2	10	0.0021	23	6.5	0.2	28	41	32	45	8	66	0.83
3	10	0.007	76	4.8	0.0	28	49	77	98	54	100	0.77
4	10	0.099	1.1e+03	1.1	0.0	28	46	111	129	108	135	0.85
5	10	0.048	5.3e+02	2.1	0.0	28	48	145	165	136	169	0.85
6	10	0.036	3.9e+02	2.6	0.0	28	48	179	199	156	203	0.75
7	10	0.051	5.5e+02	2.1	0.0	28	48	213	233	203	236	0.86
8	10	0.048	5.3e+02	2.1	0.0	28	48	247	267	228	271	0.82
9	10	0.031	3.3e+02	2.8	0.0	28	48	281	301	258	304	0.75
10	10	0.047	5.1e+02	2.2	0.0	28	48	315	335	293	338	0.79

Coding Sequence: ATGCAAGTGGTACTACCTAGCCCCACGAGGCAAGATGCAAGTAGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGTCCCACGAGGCAAGATGCAAGTGTACTACCTAGCCCCACGAGGCAAGATGCAAGTAGTACTACCCAGCCCCACGAGACAAGATGCAAGTGGTACTACCCAGTTCCACGAGGCAAGATGCAAGTGGTACTACCTAGCCCCACGAGGCAAGATGCAAGTAGTACTACCCAGCCCCACGAGGCAAGATGCAAGTAGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGTCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGTCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGTCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTGCTACCCAGCCCCACGAGGCAAGATGCAAGTGGTGCTACCCAGTCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTGCTACCCAGTCCCACGAGGCAAGATGCAAGTGGTGCTACCCAGTCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTGCTACCCAGCCCCACGAGGCAAGATGCAAGTGGTACTACCCAGCCCCACGAGGCAAGATGCAAGTGGTAATACTCAGCCGAACGAGGCAAGATGTAAGTAG
Protein Sequence: MQVVLPSPTRQDASSTTQPHEARCKWYYPVPRGKMQVYYLAPRGKMQVVLPSPTRQDASGTTQFHEARCKWYYLAPRGKMQVVLPSPTRQDASSTTQPHEARCKWYYPVPRGKMQVVLPSPTRQDASGTTQSHEARCKWYYPAPRGKMQVVLPSPTRQDASGTTQPHEARCKWYYPVPRGKMQVVLPSPTRQDASGTTQPHEARCKWCYPAPRGKMQVVLPSPTRQDASGTTQPHEARCKWCYPVPRGKMQVVLPSPTRQDASGTTQPHEARCKWYYPAPRGKMQVVLPSPTRQDASGTTQPHEARCKWCYPAPRGKMQVVLPSPTRQDASGNTQPNEARCK

Sequence clustering based on sequence similarity using MMseqs2