Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_902151445.1
Location
CABFVZ010000841.1:66066-79773[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.6e-17 3.6e-13 51.0 0.0 8 69 457 516 451 536 0.88
2 2 3.3 3.4e+04 -3.4 0.0 39 50 643 654 636 667 0.73

Sequence Information

Coding Sequence
ATGAAGGAAAGTCGAACACGTTCTTCAAAGTCAAAGACCCCAACAGATACAAGCCAACAGGCTAAAATGAAAGgttcaaatgaaaaatataagagTGTGCCAGAAGATAATCTTGTTAAATCAAGAATTCTTGGAGAAAACTCAAGTGATTTGTGTGTGTCACCTACTAAGTCTGAAGACTCGGAACAAGAATCTTTGTCTTCTCTAGTGGCAGGAGCTAGCACAAGCATTGTTGAGAAGCACGGGCAAGATGAATCAGAATCTGGTGCAAGGCATGAAGGTTCTGGTATAAACTTTCATCCTGGCTTGCGGTTGGAAGCTAAGGATTTGGGCAATGACAAGTGGTACGGTGTGAAAGTTGTAGAAGTGGATTGGGTCGAAGAAGatgttttaattcattttgaGAAATGGTCTCAGCGTTACGATGAATGGATTTCTATGGACAGCCCTCGGTTACGTTCACCTCAGAAACCTGAACCACAACCAGAGAGTAAGCCAATCAGCTTTTTCAATGTTGGGGATGAAGTCATGGCAGCATGGACAGACAATCGCAGATACCCAGCTAAAGTCAAAGCAGTTGCAGCAAATAATAAATTTGAAGTTGTGTTTTTTGACGGATTCacaaaatttatcaaaggtTCCAAAATGCATAAACTGACAGAAGGAGAGTTAGAAAACATGAAAGAGaaaattcCATCTCCACTTGCAAATGAAATTTCCCTGCAAACACCTGCTGTGTATATAAGGCCAAAGAAGATAAACATATTCACAGATGTTTCACCAGAAGGAATCGGTTCAAAGGAAGACAGGAGGCAGAGGAAAAGGAAGTTAAATGTCGCAGAGCTGTTTGTCTCAAAGAAACGTCGTGTTGGAAGTTTTGATTTTTCCCCACCAAGACAAGATATAGAAAGAGTAACAAAACTGGATTTGGGAAAGCAAGGAAAAGCTTTCGGCAATGTTAGCTCTGCCAACAAGAAAGAGAGCAATCAATCTTTTGAGGATGCCAATCAAAAGGCTTCCTCTGCGCCTAATGATCAAACAAAAGTCGAAAGTAAATCTGAATCTATTGGAAGGAGTCGCAGAAAATCAGGTCAGCCAGTGGTGACAGAGaatgtagaaaataaacaaagtgtaaaaaaagcaaaaataattaGTGGTAAGGCAAGGAAGAGAAGccgaaaattaaactttgatgaAATCTCAACTTCATCAAGCAAGGTATCAAAAGATAATGAATCACCTAGGAGTAAGAAGAAATCAGTTGATCCAGACAATGAGCTTGAAGTTGGGACAAAGTGGGAACCAGAAGGGGATACTGCATACGTTGTCGAGAGTACAGCAGGTCTACGCAGATCCATCATAATAGCTGATTCGAGGCTGCCTTCTGGCTGGGCAAAGCATACAATTCAACGTCGGAGTGGCAATTCTGCTGGGAAGTGGGATGTGTTCCTGGTTGGGCCTGCAGGCCGCAAGTTCCGCACACGTGCTGAGCTTCGGACCTACTTTGAGGAAAGGAAGGAACCATTTGAAGAAGCTTTGTTTGACTTTGGCTTGGGTAGGCGGAAGCTTGTGAAAGTTGCTGCAAACTCTAATACCCCTGCTTTGAAGCCTTCATCTTCATCCaaagtATCTCGCAGTTCAGGAAAAAATAAGCACTCCAGTAGCCCTATTGAGAATGCTACCCCCCAGGATCCTCCACTCCAGAGGAGGATCAAGACACTCCTTCCCAAGATTCGACCCCCTCACTCGGAAGGAGAGAAGGAAGAGAAAAGTGCTGCTGACACAGAGGGCCCCCCACCTCCTTATACCACCACAGTGGCAGCTAACTCTGCTGTCAAGGTCCCTGATCCGGTTGATGGGCAAGtGTTTGTTGGAGGTCTTAAAATACAAATGGAAAATGATGCATACAAATGTCCTAAAGAAGGTTGTGGTAAGACTTTCCGCAAGGAAAACTTATTGCAGATGCATTTGAAACACTATCATCCTGAGTATAATAAGTTTATGGGCTCTACACCAAATGTGGCAGACCTTGCATATGCTCGGACTATTGGGGAGAACCTGGAAGATTTAATGCCAAAGTCTCGGTTCACCTTCACCACTGTGACTCCCTTTGGCACGGAGAAGAGCGCCCGCATTGAGAACACCAGAAAGTCAAGAACACTTTCCCCTTCTGATGCATTCAATTCTGACAAGAAGAAAGATAAAAACCCTGTCATTGCTACAACcaagaaacttttaaaagggTAA
Protein Sequence
MKESRTRSSKSKTPTDTSQQAKMKGSNEKYKSVPEDNLVKSRILGENSSDLCVSPTKSEDSEQESLSSLVAGASTSIVEKHGQDESESGARHEGSGINFHPGLRLEAKDLGNDKWYGVKVVEVDWVEEDVLIHFEKWSQRYDEWISMDSPRLRSPQKPEPQPESKPISFFNVGDEVMAAWTDNRRYPAKVKAVAANNKFEVVFFDGFTKFIKGSKMHKLTEGELENMKEKIPSPLANEISLQTPAVYIRPKKINIFTDVSPEGIGSKEDRRQRKRKLNVAELFVSKKRRVGSFDFSPPRQDIERVTKLDLGKQGKAFGNVSSANKKESNQSFEDANQKASSAPNDQTKVESKSESIGRSRRKSGQPVVTENVENKQSVKKAKIISGKARKRSRKLNFDEISTSSSKVSKDNESPRSKKKSVDPDNELEVGTKWEPEGDTAYVVESTAGLRRSIIIADSRLPSGWAKHTIQRRSGNSAGKWDVFLVGPAGRKFRTRAELRTYFEERKEPFEEALFDFGLGRRKLVKVAANSNTPALKPSSSSKVSRSSGKNKHSSSPIENATPQDPPLQRRIKTLLPKIRPPHSEGEKEEKSAADTEGPPPPYTTTVAANSAVKVPDPVDGQVFVGGLKIQMENDAYKCPKEGCGKTFRKENLLQMHLKHYHPEYNKFMGSTPNVADLAYARTIGENLEDLMPKSRFTFTTVTPFGTEKSARIENTRKSRTLSPSDAFNSDKKKDKNPVIATTKKLLKG*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-