Tgen007927.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Timema genevievae
Gene Symbol
-
Assembly
GCA_902155825.1
Location
CABFWO010000371.1:83508-131623[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1 1.3e+04 -2.1 0.0 42 57 22 37 21 47 0.80
2 2 2.3e-13 2.9e-09 38.4 0.0 9 72 241 302 236 305 0.85

Sequence Information

Coding Sequence
atggATCTTCTCGTTCGGCGGCTGCTGCTGGTTTTACCCATCTCGTCTTGTGAGTCAGAAAGAAGTTTCAGGTCTTTCAGACGGCTGAAGACATATTTGCGTTCCACAATGACTCACAAGAGACTGAACCACATTGCCCTCTGTTATGTTCATAGTGACATCTTGGACTCAATCGATATTAGGAAAGTCACTGCAACACTGGTCTCCAgattgtGTCGAGCCAACTTGAAAAAGACCAATTCTGACTCTGATGGTCTAGACGTGGTGGCTACCATACGCATGATGGGCCCCGACGACTATTACGTTGTGACTGATGATTCTGAGTCCAAACCGGGGCCCAGCGGACTCTCCAAAACATCACAACTTGCAAACAAATCCATCACAAGCCCAGTCGTGGTTAAAGAGGAACCATTGGACAAGGATGATAATAGGTCACCTGCCTCTTCCCCTAACTCTCGCTTACAAGTGAAGTCCAACGCTGCTCTCGGTATACAGTCAGACAGCTGGAACAAACGAAAGAGCACTGATGGGACTGTCAAAAGAAAGATTTCTCCAAATGTTTCTGACAACAATCTGGATACAACCCCAGTTGCGGAAGATGGGGTGTCATTGACGAGTTCTGCAGCCAGCACTCCTTCTCAGAGCTCCTTCAGGAGTGAATCCCGGAGCAGCAAAGGGAAGATCAGGCCTACCATAGACACACTCAACCCAATTTTTAAGAAGCCTCTGGAAATGGGCTGGAGACGAGAGTTGGTGTATAGAAACGCAATAGACAGCAGCAACAGACGTAATTGTGATGTGTACTACTACACCCCCCAGGGCAGGAAGGTGCGATCTTCAAAGGAGGTTCTGGATCATATTGATGGAGTCAAGTTAACCTTGAAAAACTTTACATTCGCCAAAGACACACTCGGGACAAATGATCCCGAAAAGGAGATAGTGAGGGATGCAAGAAGAGTCAGCGGCAGGGAACCCAGTTCAACACCACCCAAGAAAACTCCTAAAGCAAGGCCGAAACCAGTACAAACAAAGCTAAAGATGAACTTTGATGTAAAGACTGAGCCCGATTCCCCAACCCCACCCTCCCCTACGGTGTCATCTCTTAGCCCTTTGTCGCCTAACATGTCGCCAACTGTTCTGCTGAAGAGAGCAGTAATTCCTCCTGGCACAACCACCACGAAGAGCTCTTTGTTCACCAACTACCCCAAAATTAAACTGTCTCGTTATGTAAAACCAGTCAAGAAGAAGCCAGTCACATCTACACCCACACCTACCGTTGTAGCTAAACCTTTAGTTAGCAATATTAAGATCAAACGTCATCAACGGTCACGGTCATCTGATGATGATAACCGTGAGAACTCTGATGATATGGAAATGGGAATGTTGCCCCCAACGTGGGAAGTAGACTCTGCGGGAAAGAAGGGCAGCGGAACAAACAAGAACTCTTGGAGCAGCGCAAATGACCCTCCTCATCTCTCTCCTGTGAACTCGGACTCTTCCCTAACTACGACTTGCAGGATATTTGTGACTCTCAAGCTTCTTGGTTGCAGCCAGAGACAgtttTTCATCACAAACTGTGTACTCTTTGTTCTTCCTGTCCTCTCTTGCTTCCGCTCCATCTCCTCGACTTCCCTACTCTACCTCGCACACGCGCACGGTTGCAGGGGCAGCAATAAACTGAGTGAGCCCTGCTCTATCCGGTGCTTGGGCGTGATGGGTCTTATCCCTTCACTACAGTGCCGACTGTGTCTGTGTCTCTACCATCCAGAATGTGTTGGTCTAGGCACCATCACTGAGACCATCCACAGCTATGTCTGCAAGAATTGCCAACAGGAAATCAAAGAAGGCAAAACTTCCCTCGTCACTGTGTCCAAACTTTTTAGTCCCGCCGTTGCCAAGTCCATGAACACTAGCAAACTGGTGAGCCCTAAGCTGTCCCCTGCCACCAAGCCCCCTGCTCTAACCCCTATCAACATATTTGGGATGAGTAAATCTGCCAATCTCAAGGCTGGTCAGAATGTGCTCCGTTTGCCCACTGTCCCAACACTCCGCCCCACTACCTCTCCCCCAAAAATATCACACCCAGGGGAACCCCAGAAACTACAAACTATATCCCGTTTGGTGAAAGTCTCTGCCAAAAACAGAGACTCCTTGTTGTTGCCAAAGATCCCACTGAATGTGGCTGCCACCAAAACAAACACAGTTCGCGACAAAACAATTGTCGGTTCTGTCACAACTTGGTTGCCTCCCTCTTCCACCATTCAATTGAACTCCTCTACGGTTTTGCTCCCTCCTACCACAAGTATAGTTACATCTAGTAGCACGCCCAATGCTACCACGGTTGTCTCCCCTGAATCGTCTGCTGCCTCTCGGGCACTCTCCGTCGTTTGGATTGATGGAAGCAAGTATGTGGTCACTCCAAAACACAACGTCATGTCAGTCTCCCCCTCCCCTGCACTAACTGCAACCACACCTAGTCTCCGCTCTACCACAGGAGATACCACTCCTTCTGGAGACAAACCCCCAGTAAGTTTGACCATCCCCTCGACAACTCTCATAGCTGCCAGTCAAGGTTCCTCTGTTCAGAATTCAACACAATCCATGTTGGGGCAGTCTCAGGTATTGCTTGCCACGTCTGCCAGTGGAGGGCAGTCAATGAGTATAGTCCAAACAACATCTGCTAGTTTCACTCAACAGCAGTTGACTAGTTTTGTTTCTGGTGCATCAGGAACTCCTATCCTCCCAAAACCTTCCCCCACATCTACCTACATTGTGAGCTCCCCTGGTACAGCGGGGATACAGAATCCCGCAGGTGTGCTCCTTGTTCCCCTAATTACCACCGGGGACAGCAAAGGGACCCCACAACACCCGCAATACCTCATACTAAATTCTCCCACTGGAGGACTACAAGGTGGCAGTTTCATCGTCAGCAGTCTTCCCTCTGCGGCTCCGCAGTCTTTAGTGCAGGATGCATCTGCAGAGGAAGGGGACATGTCAGATGAAAAGGCTGGTGATGGAAGTCGCAAGCGCAAGGCGGGCAAGCAACAGGGCGAAGGCCCAGTGACCAAGATGGCCCGTGTGAATTCCGGACCTATTATGCCTCGGTTGTTTGTGAACGCTCAACACATTAGCTCGGGCTATGGGGCACTCCTGCACTTGTTCCAGTACCTCAAGGTTCAGGAACTGCTGCGTGCCGCTCTAGTGGACAAGATGTGGCATGATCTGGCCGCCCATTCTTCACTGTGGAAGACTGTGCGCCTAAAAAACTCTCAGGTGCATGATTGGGAGGGTTGCTCGGCTGCTCTGTCCCGGCATCGAACCCAGCACTTGGACCTGCGCAAGATGTTGGTCCCTCAAAACACTGACTCCATGTGGACAGAGTTCTGCAAAGCCATGGCCAAAGTCGACTCTCTGGAGAGGTTGGACCTGTGCCGATGCAGCGCCAGCACTGTGGAGCAGGTCTGCGCCTCCTGCACTCAACTCAAAGTCCTCAACGCACAGGCCATCAGGTGCCAGCTGATGAACTTTGAGCCATTCCAGAACTTGTCATGCTTGGAGGAGCTACGACTGAAGAGTGTATCGGGGATAAGACTCAAGAACCCCCTTGACCCGATATGTCAGCTGACTACTCTCAGGCATCttGCACTGACTACATTCAAAGACCTGGGTAAGCAGAACCCCAGCAGTTTGGGGTCTCTGGTGAACTTGGAGTCCCTAGAGCTGGGGGAGTGCAGTGACCTCCCGGCCAACTTTCCAGAGGGAACACTTGCTAAGCTGTCAAAACTTCGCCGGCTGCGTTTGGAGAAGGTGCAAGGAGGGGAATGCCCCACATTCAGTTACTTACAGGTGATCAGGACGTTGCCAGAGCTAGTCCAACTAGAACTTGTCAATTTTGACGTCAAACCAGGGTTTGACGAGGAGTTGGCTCTGTGTACACAGCTCACCAAGCTGCTTATCATCCCCACCTATGTCACACAGTCTGCAACATCCAACCGCATGGTGATGAATGGCATTGGTCACCTACAGGAGCGCTTGACCCATTTTGTGTGGGGGGTGACCCATGAGCTGCTGCGTGTAACTGAGCTGTTTGTAGTGCAGTGCGAGGGGAAGAGTGGACGCACAGGTGTCAAAAGAACTGACAAGAAGGAGAACAGCATTCCCGTATTGAAACCTGTCCCCGGTGACCCTGACAGCCTCGCAGATGACCGGGCAGCAGCGTCCTCTGACAATGAGGAAGGGGGCGGCTCTCCGGACACCAGTCCCCGCGACGAAGATCTCAAGTCAGCCATTGAGGGGATGAAACCACCTCCGGGAACGCCCCCCCAGGTAGAGATTGTACCGCTGCCTAAACTACAGAGAATCTTAGCTGCCGCGCTACCTCAcactaaaatcaaaatcttgaaGATCCCCTACCATGCCACTTGGAGGCAGTACCTAACAGACAAAGATGTGTGA
Protein Sequence
MDLLVRRLLLVLPISSCESERSFRSFRRLKTYLRSTMTHKRLNHIALCYVHSDILDSIDIRKVTATLVSRLCRANLKKTNSDSDGLDVVATIRMMGPDDYYVVTDDSESKPGPSGLSKTSQLANKSITSPVVVKEEPLDKDDNRSPASSPNSRLQVKSNAALGIQSDSWNKRKSTDGTVKRKISPNVSDNNLDTTPVAEDGVSLTSSAASTPSQSSFRSESRSSKGKIRPTIDTLNPIFKKPLEMGWRRELVYRNAIDSSNRRNCDVYYYTPQGRKVRSSKEVLDHIDGVKLTLKNFTFAKDTLGTNDPEKEIVRDARRVSGREPSSTPPKKTPKARPKPVQTKLKMNFDVKTEPDSPTPPSPTVSSLSPLSPNMSPTVLLKRAVIPPGTTTTKSSLFTNYPKIKLSRYVKPVKKKPVTSTPTPTVVAKPLVSNIKIKRHQRSRSSDDDNRENSDDMEMGMLPPTWEVDSAGKKGSGTNKNSWSSANDPPHLSPVNSDSSLTTTCRIFVTLKLLGCSQRQFFITNCVLFVLPVLSCFRSISSTSLLYLAHAHGCRGSNKLSEPCSIRCLGVMGLIPSLQCRLCLCLYHPECVGLGTITETIHSYVCKNCQQEIKEGKTSLVTVSKLFSPAVAKSMNTSKLVSPKLSPATKPPALTPINIFGMSKSANLKAGQNVLRLPTVPTLRPTTSPPKISHPGEPQKLQTISRLVKVSAKNRDSLLLPKIPLNVAATKTNTVRDKTIVGSVTTWLPPSSTIQLNSSTVLLPPTTSIVTSSSTPNATTVVSPESSAASRALSVVWIDGSKYVVTPKHNVMSVSPSPALTATTPSLRSTTGDTTPSGDKPPVSLTIPSTTLIAASQGSSVQNSTQSMLGQSQVLLATSASGGQSMSIVQTTSASFTQQQLTSFVSGASGTPILPKPSPTSTYIVSSPGTAGIQNPAGVLLVPLITTGDSKGTPQHPQYLILNSPTGGLQGGSFIVSSLPSAAPQSLVQDASAEEGDMSDEKAGDGSRKRKAGKQQGEGPVTKMARVNSGPIMPRLFVNAQHISSGYGALLHLFQYLKVQELLRAALVDKMWHDLAAHSSLWKTVRLKNSQVHDWEGCSAALSRHRTQHLDLRKMLVPQNTDSMWTEFCKAMAKVDSLERLDLCRCSASTVEQVCASCTQLKVLNAQAIRCQLMNFEPFQNLSCLEELRLKSVSGIRLKNPLDPICQLTTLRHLALTTFKDLGKQNPSSLGSLVNLESLELGECSDLPANFPEGTLAKLSKLRRLRLEKVQGGECPTFSYLQVIRTLPELVQLELVNFDVKPGFDEELALCTQLTKLLIIPTYVTQSATSNRMVMNGIGHLQERLTHFVWGVTHELLRVTELFVVQCEGKSGRTGVKRTDKKENSIPVLKPVPGDPDSLADDRAAASSDNEEGGGSPDTSPRDEDLKSAIEGMKPPPGTPPQVEIVPLPKLQRILAAALPHTKIKILKIPYHATWRQYLTDKDV*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01448577; iTF_01445678; iTF_01449632;
90% Identity
iTF_01445678;
80% Identity
-