Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_902155825.1
Location
CABFWO010001501.1:7811-55091[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5e-17 6.2e-13 50.1 0.1 8 69 398 457 392 467 0.87
2 2 2 2.4e+04 -3.0 0.0 51 74 967 990 966 992 0.86

Sequence Information

Coding Sequence
ATGAAGGAAAGTCGAACGCGTTCTTCAAAGTCAAAGACCCCAACAGATACAAGCCAACAGGCTAAAATGAAAGGTTCAAGTGAAAAATATAAGAATGTGCCAGAAGATAATCTTGTTAAATCAAGAATTCTTGGAGAAAACTCAAGTGATTTGTGTGTGTCACCTTATAAGTCTGAAGACTCGGAACAAGAATCTTTGTCTTCTCTAGCGGCAGGAGCTAGCACAAGCATTGTTGAGAAGCACGGGCAAGATGAATCAGAATCTGGTGCAAGGCATGAAGGTTCTGGTATAAACTTTCATCCTGGCTTGCGGTTGGAAGCTAAGGATTTGGGCAATGACAAGTGGTACGGTGTGAAAGTTGTGGAAGTGGATTGGGTCGAAGAAGATGTTTTGATTCACTTTGAGAAATGGTCTCAGCGTTATGATGAATGGATTTCTATGGACAGCCCTCGGCTACGTTCAGCTCAGAAGCCTGAACCACAACCAGAGAGTAAGCCAATCGGCTTGTTCAATGTTGGGGATGAAGTCATGGCAGCATGGACAGACAATCGCAGATACCCGGCTAAAGTCAAAGCAGTTGCACCAAATAATAAATTTGAAGTTGTGTTCTTTGACGGATTCACAAAATTGATCAAAGGTTCCAAAATGCATAAACTGACAGAAGGGGAGTTAGAAAATATGAAAGAGCAAACTCCTGCTGTGTATGTCAGGCCAAAGAAGGTAAACATATTCACAGATGTTTCACCAGAAGGAATCGGTTCAAAGGAAGACAGGAGGCAGAGGAAAAGGAAGTTAAATGTCGCAGAGCTGTTTGTCTCAAAGAAACGTCGTGTTGGAAGTTTTGATTTTTCCCCGCCAAGAGATATAGAGAGAGTAACAAAACTGGATTTGGGAAAGCAAGGAAAAGCTGTTGGCAATGCTAGCTCTCCCAACAAGAAAGAGAGCAATCAATCTTTTGAGGATGCCAACCAAAAGGATTCCTCTGCGCCTAGTGATCCAACAATAGTCGAAAGTAAATCTGAATCTATTGGAAGGAGTCGCAGAAAATCAGATAATGAATCACCTAGGATTAAGAAGAAATCAATTGATCCAGACAATGAGCTTCAAGTTGGGGCAAAGTGGGAACCAGAAGGGGATACTGCATACGTTGTCGAAAGTACAGCGGGTCTACGCAGGTCTATCATAATAGCCGATCCAAGACTGCCTTCTGGATGGGCAAAGCATACGATTCAGCGTCGGAGTGGCAATTCTGCTGGGAAGTGGGATGTGTTCCTGGTTGGGCCTAAAGGCCGTAAGTTCCGCACACGTGCCGAGCTTCGGACCTACTTTGAGGAAAGGAAGGAGCCTTTTGAAGAAGCTTTGTTTGACTTTGGATTGGGTAGACGGAAGCTTGTGAAAGTTGCCGCCAACTCTGACACCCCTGCTTTGAAGCCTTCATCTTCATCCaaagtATCTCGCAGTTCAGGAAAAAATAAGCACTCCAGTAGCCCTATCGAGAATGCTACCCCCCTGGATCCTCCACTCCAGAGGAGGATCAAGACACTCCTTCCCAAGATTCGACCCCCTCACTCAGAGGGAGAGAAGGAAGAGAAAAGTGCTGCTGACACAGAGGGCCCCCCACCTCCTTATACCACCACAGTGGCAGCTAACTCGGCTGTCAAGGTCCCTGATCCAGTTGATGGGCAAGtgTTTGTTGGAGGTCTTAAAATACAAATGGAAAATGATGCATACAAATGTCCTAAAGAAGGTTGTGGTAAGACTTTTCGCAAGGAAAACTTATTGCAGATGCATTTGAAACACTACCATCCTGAGTATAATAAGTTTATGGGCTCTACACCAAATGTGGCAGACCTGGCATATGCTCGCACTATCGGGGAGAACTTGGAAGATTTAATGCCAAAGTCTCGGTTCACCTTCACCACTGTGACTCCCTTTGGTATGGAGAAGAGCGCCCGCATCGAGAACACCAGAAAGTCAAGAACACTTTCCCCTGCTGATGCATTCAATTCTGATAAGAAGAAAGATAAAACCCCTGTCATTGCTACAACcaagaaacttttaaaaggTGAACAAGAGGAGAAGCCACAGCTTCACGAGTCTGGGACAGAACCGGCCCAGTGCACGCCTGGCCAAGGGGTGGGTGAGGAAATGTCTGTCCCGAGTGAAACCACCACATCCAATACACCCCTAGCTGATGTGAAGGAGGAGAGGAAAGAACCagacaatatttcaaaactacCCCTTTCAACATCCGAACAGACCACAGAGATGACCACTACTGACAGACCTGCAGAAGATTGTGAAGATGATCACATAGATGTGGTGGATGATAAAGATGTTCAACAACCTGACTCTCCTCAATCCAGCACCTGCGTCTCAAAGGTCCTGCGATCTGTGCGCAAAAGGCAATTATCTGGGCCTTCCCCTGACACAACATTAAAGAAGCGTAAGCTAGACTTGCTGGACGAGGGGGATGGAACAGAGGAGGGGAGCTGTTCTCTGGATGGAAGTAAGTTCTCTTCTACATTCCGTATTAACAAAAAGAAACTGCCGATGATTCACCTTGAGAAGCTCAGTGTCACAACAGACTCGAATGGTCACATCATTCACATCCTTCCTTCCTCACGTGGAACTAGCGACGGACTGACTCAACACTCAGATGCTGCAGAGGAGGAAAGTAAGTCTCCTCTTGAACAATCCAAATTTGAGCATCTACGTAAAGAGGAGCTCATCAACTGTACCTGTGGCTACTCAGAGGAGGATGGTCTCATGATACAGTGTGATCTGTGCCTGTGCTGGCAACACGGCATCTGTAACAACATTGAAAAGGAGGGGGATGTCCCTGAGAAGTACACTTGTTCCATTTGTCTCAACCCCTACAGAGAACGAGTCAGCAAGAAGTACCTCCACGACCAGGATTGGCTCAAAGAAGGAAAACTACCCAGCCTTTCATTTCGCACCAAGAATGCTAGCGATGTGAATCACCGCGAGAGGTTGTTGAAACGCTCCCACGATGTGACAGGAATGCTGCTTCAGGTTCAACATGTGGCGCAAGGTCTACGAGTGAAGCTTAACATTGCAGAGAAACCAGATCATCCCAAGTTATATCTGTGGGCAAAGAGCTGGGAAAAGGCATCTAAGTTGGAGGGTTTGAAAACTGAAAGTGACatcaaagttgaagataaaacAGataatacaGACTCCTCAGCTCAACCTGGCGTGATGGAGACAGAATGTGATACCACGTCAAGCGCCAACAGCAAGAAAGCGACAGATGAAGGTGTTGAGAAAGACACACATAGTGAAGACTTGAAGTCTTTGTTGAACGATCAAGGTGATCTTGGTCTAGAACCGCAGCAGACAGGTGATACAAGCAATAGGGTCGACGGTAGAGCTGACTACACCAGGCCTGATAGTTCACTCCTTCATCAGGCGCTTACTAATGGTGCAACTAACCAACATGACAATATGTTGCAATTACCTATTTGTCAGAACGAGCTCATGCATTTCGCCAGCACAATGGCCGGAAAACTCGATGCTACAGAGCTCCCAAATTCTCCCCAGCCTGAGGCCCCCATTGACCCCATGGAGTGTCGACTTGCGCTCTTGGACCACATCGAACACTCTCAGCAGCTCATTGACTCCAGGCTGTCTTCCTTTGAGGCTCAGGTTGCAGGTACTGCATCTTGGTTTGTTGCAAGGGTAGGAACCTTTGACTTGATGTTTGTTGTTTATGGCTGGGTCGGGCAATTTAGGGTGAACCAGAATGAGAACCAGAGATTTGGGGGGGTGTTTGAATGA
Protein Sequence
MKESRTRSSKSKTPTDTSQQAKMKGSSEKYKNVPEDNLVKSRILGENSSDLCVSPYKSEDSEQESLSSLAAGASTSIVEKHGQDESESGARHEGSGINFHPGLRLEAKDLGNDKWYGVKVVEVDWVEEDVLIHFEKWSQRYDEWISMDSPRLRSAQKPEPQPESKPIGLFNVGDEVMAAWTDNRRYPAKVKAVAPNNKFEVVFFDGFTKLIKGSKMHKLTEGELENMKEQTPAVYVRPKKVNIFTDVSPEGIGSKEDRRQRKRKLNVAELFVSKKRRVGSFDFSPPRDIERVTKLDLGKQGKAVGNASSPNKKESNQSFEDANQKDSSAPSDPTIVESKSESIGRSRRKSDNESPRIKKKSIDPDNELQVGAKWEPEGDTAYVVESTAGLRRSIIIADPRLPSGWAKHTIQRRSGNSAGKWDVFLVGPKGRKFRTRAELRTYFEERKEPFEEALFDFGLGRRKLVKVAANSDTPALKPSSSSKVSRSSGKNKHSSSPIENATPLDPPLQRRIKTLLPKIRPPHSEGEKEEKSAADTEGPPPPYTTTVAANSAVKVPDPVDGQVFVGGLKIQMENDAYKCPKEGCGKTFRKENLLQMHLKHYHPEYNKFMGSTPNVADLAYARTIGENLEDLMPKSRFTFTTVTPFGMEKSARIENTRKSRTLSPADAFNSDKKKDKTPVIATTKKLLKGEQEEKPQLHESGTEPAQCTPGQGVGEEMSVPSETTTSNTPLADVKEERKEPDNISKLPLSTSEQTTEMTTTDRPAEDCEDDHIDVVDDKDVQQPDSPQSSTCVSKVLRSVRKRQLSGPSPDTTLKKRKLDLLDEGDGTEEGSCSLDGSKFSSTFRINKKKLPMIHLEKLSVTTDSNGHIIHILPSSRGTSDGLTQHSDAAEEESKSPLEQSKFEHLRKEELINCTCGYSEEDGLMIQCDLCLCWQHGICNNIEKEGDVPEKYTCSICLNPYRERVSKKYLHDQDWLKEGKLPSLSFRTKNASDVNHRERLLKRSHDVTGMLLQVQHVAQGLRVKLNIAEKPDHPKLYLWAKSWEKASKLEGLKTESDIKVEDKTDNTDSSAQPGVMETECDTTSSANSKKATDEGVEKDTHSEDLKSLLNDQGDLGLEPQQTGDTSNRVDGRADYTRPDSSLLHQALTNGATNQHDNMLQLPICQNELMHFASTMAGKLDATELPNSPQPEAPIDPMECRLALLDHIEHSQQLIDSRLSSFEAQVAGTASWFVARVGTFDLMFVVYGWVGQFRVNQNENQRFGGVFE*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01444789;
90% Identity
iTF_01444789;
80% Identity
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