Tgen022041.1
Basic Information
- Insect
- Timema genevievae
- Gene Symbol
- pax2a
- Assembly
- GCA_902155825.1
- Location
- CABFWO010001597.1:133147-145280[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2e-33 1.3e-29 104.6 0.8 1 55 33 87 33 90 0.97
Sequence Information
- Coding Sequence
- ATGAGGAAAGAGATCAAGGAAATATTCAGGAATAGCTCCCTCCATCCATCTGTCCGGGACTTTAATCGAACCTCTGCATCAACACAGTCAAGACTAGgtCACGGTGGGGTGAACCAGCTGGGCGGCGTGTTCGTGAACGGGCGACCCTTACCTGACGTTGTCCGTCAGAGAATAGTGGAACTGGCGCACAATGGTGTCAGACCCTGTGACATCTCCCGGCAGCTCAGGGTGTCTCATGGCTGTGTCTCCAAGATACTGTCCAGTGCCCCGCCCCCTCTTCGCGCCATGGACCAATCCCCCGTGATGGATGTGAGCGAGCTTGGTGCAAGAGTAGCTCATGTCACTTCAGAGCAATGGTCAAAAGGTGAGGCCCGCGTGAGACGAGGTCCAGATGTGGTAACCCCCCTCTACACCCCATCAAGAATACACCCTGGTGGGAACATGTCCAACCAAGCGGAGCTTGTCTTCCTCTGGCGGCGAGAAGAACAACTTCTTGTGCGCACGCAGCCAAGCCTGAAGAATGGTCACAATGCAGCCAGTAATATGGTCACAATATCTTCCCTCCCACCCCTCGCCCTGACAACGATCTATAGCTCCTGTGGCAACCAAGTTTGCGTTTAG
- Protein Sequence
- MRKEIKEIFRNSSLHPSVRDFNRTSASTQSRLGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSSAPPPLRAMDQSPVMDVSELGARVAHVTSEQWSKGEARVRRGPDVVTPLYTPSRIHPGGNMSNQAELVFLWRREEQLLVRTQPSLKNGHNAASNMVTISSLPPLALTTIYSSCGNQVCV*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -