Basic Information

Gene Symbol
Mbd2
Assembly
GCA_901482245.1
Location
CABEEJ010006257.1:24919-32548[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.7e-18 1.3e-13 52.6 0.0 10 70 104 159 98 165 0.92

Sequence Information

Coding Sequence
ATGATCTCACAAACCGCCCAACCCAAGCCCCTAGATTTCGCTGATCTCACGTGGCAAATGTCTGTACTGCTTGGACTCCGCCAACCAGTACGCGAGATCCAGTATAGGCCATGTGCGTCAAGAGGGGGAACAGGGGCGGAAAAGAACGAACCAAAAAAGGAGACAAGCAGCGCTCAGGTGGGAATAACGGGGCGCGGCTTCAATCACAAGCGGTACATGGGGTCAAACCTCATTTTAGTCCGCGGCGAAGAGTCGAAGGAAGAAGGTGCCATGACGTGTGCTCCAGTATGCCATGATAAACAAGCCAGGTGTTTACCTAAAGGTTGGGTAAGAGAAGAGGTTACGCGCCAATCTGGAGCATCAGCTGGAAAAAGAGACATTTACTATCACAGCCCAGACGGCATAAAGTTCCGCAGTAAACTGGAGTTGACCAATTACCTGGGGGATGCCTGGGACTTGACCCAGTTTAACTTCCGCCTGGGGAAAACGTTACTTGGTGATCACAAAGGGAAAAGGAAAACTCCAAAATCCTCCATTGAAAAACACGGGACAGGAATGGAGTCTCGGTCTTCAAGGGCAGGGAGGGAGGAAAGTCGGCCAAACGTTCAAAAAGGAACGCAAACTGGTGAGAAATTAGTGAGTGTGGTGGATCTCACGGAAGAACCCTCAAGTCCGTCGTTGAGATACACACCTGACAGTGAAAGATCTATATTGAAAGTTAATAGAGATAATATTTCTATATCAGAGTCAAACCAGCTCACTCGTGCACCAACAGTTGCTGcaagaaacaagaaaataccCGATAGACTACAAAATGAAGAAACCAATGTTGATTCCCGCTCTCGTGGAAAACCAAAGCTAAGACAAACCAAGGTTGCGTTGAAGTGTAATGTTTGCAAATTAGTTTTCCCCAGCTCCAAGGCTAAATACAAACACGAGCAAACACACAATCACTCTGTCTTTCAGTGTTACATTTGTAAATCCTCGTTTAGTAACGTCTCACTTCTCAGAAGGCACAAGTCCATCCATACGAATGTGAGACCATACGAGTGTCCATTTTGTAAGTATAGCTTCCGTGTCAAGTATCACCTGACAGACCACATCCGAATTCATACAGGTGAACGTCGCTTCCACTGCTCTACGTGTAGTATGAGATTCACGCAACATTCCACATACTACGCCCATCTGAGGTGTAGAGCACATCTACACAGACTCAAGGAGAAAATTAACTCGGCTGAAAGGACAGTGATTGTGTCCACGTCTACATCTCTTGATGAAGCAGACAAACTTTTAGACGTAGAAAGTGTTTGA
Protein Sequence
MISQTAQPKPLDFADLTWQMSVLLGLRQPVREIQYRPCASRGGTGAEKNEPKKETSSAQVGITGRGFNHKRYMGSNLILVRGEESKEEGAMTCAPVCHDKQARCLPKGWVREEVTRQSGASAGKRDIYYHSPDGIKFRSKLELTNYLGDAWDLTQFNFRLGKTLLGDHKGKRKTPKSSIEKHGTGMESRSSRAGREESRPNVQKGTQTGEKLVSVVDLTEEPSSPSLRYTPDSERSILKVNRDNISISESNQLTRAPTVAARNKKIPDRLQNEETNVDSRSRGKPKLRQTKVALKCNVCKLVFPSSKAKYKHEQTHNHSVFQCYICKSSFSNVSLLRRHKSIHTNVRPYECPFCKYSFRVKYHLTDHIRIHTGERRFHCSTCSMRFTQHSTYYAHLRCRAHLHRLKEKINSAERTVIVSTSTSLDEADKLLDVESV*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01447060;
80% Identity
iTF_01447060;