Basic Information

Insect: Timema bartmani
Gene Symbol: -
Assembly: GCA_902151455.1
Location: CABFWB010003933.1:13813-16895[-]

Transcription Factor Domain

TF Family: DACH
Domain: DACH domain
PFAM: AnimalTFDB
TF Group: Unclassified Structure
Description: This family of proteins includes transcription factors involved in the regulation of organogenesis. Members of this family appear to regulate the SIX1, SIX6, and possibly SIX5 genes, influencing myogenesis and the proliferation of precursor cells in myoblasts. They are known to act as corepressors or coactivators in these processes, depending on their interaction with other proteins such as EYA3, CREBBP, NCOR1, TBL1, HDAC1, and HDAC3. These proteins are also implicated in the repression of cyclin-dependent kinase inhibitors, including the p27Kip1 promoter, which is key in cell cycle regulation. Some family members inhibit TGF-beta signaling through interactions with SMAD4. They are characterized by a conserved DNA-binding domain known as the DACHbox-N or DD1 domain, which is structurally similar to the forkhead/winged helix domain and is responsible for their DNA-binding activity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.00037 11 7.8 0.3 89 152 49 110 32 116 0.75

2 14 0.00063 18 7.0 0.4 90 140 120 170 104 184 0.49

3 14 0.0009 26 6.5 0.4 98 142 170 214 158 228 0.56

4 14 0.00085 25 6.6 0.4 99 150 185 234 173 245 0.57

5 14 0.00067 19 6.9 0.5 90 140 204 254 188 268 0.49

6 14 0.00084 24 6.6 0.4 98 142 226 270 213 284 0.55

7 14 0.00075 22 6.8 0.3 98 153 268 321 257 326 0.61

8 14 0.0014 40 5.9 0.5 100 142 326 368 314 398 0.58

9 14 0.042 1.2e+03 1.1 0.1 100 142 382 424 370 439 0.65

10 14 0.041 1.2e+03 1.1 0.1 100 142 410 452 398 468 0.65

11 14 0.029 8.3e+02 1.6 0.1 99 141 465 507 442 523 0.60

12 14 0.00091 26 6.5 0.2 91 141 527 577 511 592 0.58

13 14 0.0024 69 5.2 0.1 98 141 604 647 591 663 0.54

14 14 0.00043 12 7.6 0.3 99 158 661 718 648 730 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.00037	11	7.8	0.3	89	152	49	110	32	116	0.75
2	14	0.00063	18	7.0	0.4	90	140	120	170	104	184	0.49
3	14	0.0009	26	6.5	0.4	98	142	170	214	158	228	0.56
4	14	0.00085	25	6.6	0.4	99	150	185	234	173	245	0.57
5	14	0.00067	19	6.9	0.5	90	140	204	254	188	268	0.49
6	14	0.00084	24	6.6	0.4	98	142	226	270	213	284	0.55
7	14	0.00075	22	6.8	0.3	98	153	268	321	257	326	0.61
8	14	0.0014	40	5.9	0.5	100	142	326	368	314	398	0.58
9	14	0.042	1.2e+03	1.1	0.1	100	142	382	424	370	439	0.65
10	14	0.041	1.2e+03	1.1	0.1	100	142	410	452	398	468	0.65
11	14	0.029	8.3e+02	1.6	0.1	99	141	465	507	442	523	0.60
12	14	0.00091	26	6.5	0.2	91	141	527	577	511	592	0.58
13	14	0.0024	69	5.2	0.1	98	141	604	647	591	663	0.54
14	14	0.00043	12	7.6	0.3	99	158	661	718	648	730	0.80

Sequence Information

Coding Sequence: ATGTATTATAACAGAGCATACCTGGATGATTCCAGCCTCCAGCTGTGCCAAGGTCTCGTACACACCAGCGAACGGAATGGCGAATCGAACGCTGAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCACGAAGTGCTGCAACATTCCATCAAACCTGCAACAAAATCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAATAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAAAATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCACGCAAAGTGCTGCAACATTACATTAAACCTGCAACAAAACCACGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCACGCAAAGTGCTGCAAAATTCCATTAAACCTGCAATAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCACGCGCATTTCCCCGATCCCCCCAATGTTGGTATCTCGACGGACCATCAAAGAGAGGTGTGCGAACATGTTTCAACAGTGTGGCCGGGTAA
Protein Sequence: MYYNRAYLDDSSLQLCQGLVHTSERNGESNAEPRKVLQHSIKPATKPHEVLQHSIKPATKSRKVLQHSIKPAIKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQNSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHYIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQNSIKPAIKPRKVLQHSIKPATKPRAFPRSPQCWYLDGPSKRGVRTCFNSVAG*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -