Basic Information

Gene Symbol
-
Assembly
GCA_902151455.1
Location
CABFWB010003933.1:13813-16895[-]

Transcription Factor Domain

TF Family
DACH
Domain
DACH domain
PFAM
AnimalTFDB
TF Group
Unclassified Structure
Description
This family of proteins includes transcription factors involved in the regulation of organogenesis. Members of this family appear to regulate the SIX1, SIX6, and possibly SIX5 genes, influencing myogenesis and the proliferation of precursor cells in myoblasts. They are known to act as corepressors or coactivators in these processes, depending on their interaction with other proteins such as EYA3, CREBBP, NCOR1, TBL1, HDAC1, and HDAC3. These proteins are also implicated in the repression of cyclin-dependent kinase inhibitors, including the p27Kip1 promoter, which is key in cell cycle regulation. Some family members inhibit TGF-beta signaling through interactions with SMAD4. They are characterized by a conserved DNA-binding domain known as the DACHbox-N or DD1 domain, which is structurally similar to the forkhead/winged helix domain and is responsible for their DNA-binding activity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.00037 11 7.8 0.3 89 152 49 110 32 116 0.75
2 14 0.00063 18 7.0 0.4 90 140 120 170 104 184 0.49
3 14 0.0009 26 6.5 0.4 98 142 170 214 158 228 0.56
4 14 0.00085 25 6.6 0.4 99 150 185 234 173 245 0.57
5 14 0.00067 19 6.9 0.5 90 140 204 254 188 268 0.49
6 14 0.00084 24 6.6 0.4 98 142 226 270 213 284 0.55
7 14 0.00075 22 6.8 0.3 98 153 268 321 257 326 0.61
8 14 0.0014 40 5.9 0.5 100 142 326 368 314 398 0.58
9 14 0.042 1.2e+03 1.1 0.1 100 142 382 424 370 439 0.65
10 14 0.041 1.2e+03 1.1 0.1 100 142 410 452 398 468 0.65
11 14 0.029 8.3e+02 1.6 0.1 99 141 465 507 442 523 0.60
12 14 0.00091 26 6.5 0.2 91 141 527 577 511 592 0.58
13 14 0.0024 69 5.2 0.1 98 141 604 647 591 663 0.54
14 14 0.00043 12 7.6 0.3 99 158 661 718 648 730 0.80

Sequence Information

Coding Sequence
ATGTATTATAACAGAGCATACCTGGATGATTCCAGCCTCCAGCTGTGCCAAGGTCTCGTACACACCAGCGAACGGAATGGCGAATCGAACGCTGAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCACGAAGTGCTGCAACATTCCATCAAACCTGCAACAAAATCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAATAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAAAATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCACGCAAAGTGCTGCAACATTACATTAAACCTGCAACAAAACCACGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCTACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATTAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCACGCAAAGTGCTGCAAAATTCCATTAAACCTGCAATAAAACCGCGCAAAGTGCTGCAACATTCCATCAAACCTGCAACAAAACCACGCGCATTTCCCCGATCCCCCCAATGTTGGTATCTCGACGGACCATCAAAGAGAGGTGTGCGAACATGTTTCAACAGTGTGGCCGGGTAA
Protein Sequence
MYYNRAYLDDSSLQLCQGLVHTSERNGESNAEPRKVLQHSIKPATKPHEVLQHSIKPATKSRKVLQHSIKPAIKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQNSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHYIKPATKPRKVLQHSIKPATKPRKVLLHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQHSIKPATKPRKVLQNSIKPAIKPRKVLQHSIKPATKPRAFPRSPQCWYLDGPSKRGVRTCFNSVAG*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-