DACH
- Domain
- DACH domain
- Group
- Unclassified Structure
- PFAM
- AnimalTFDB
- Desciption
- This family of proteins includes transcription factors involved in the regulation of organogenesis. Members of this family appear to regulate the SIX1, SIX6, and possibly SIX5 genes, influencing myogenesis and the proliferation of precursor cells in myoblasts. They are known to act as corepressors or coactivators in these processes, depending on their interaction with other proteins such as EYA3, CREBBP, NCOR1, TBL1, HDAC1, and HDAC3. These proteins are also implicated in the repression of cyclin-dependent kinase inhibitors, including the p27Kip1 promoter, which is key in cell cycle regulation. Some family members inhibit TGF-beta signaling through interactions with SMAD4. They are characterized by a conserved DNA-binding domain known as the DACHbox-N or DD1 domain, which is structurally similar to the forkhead/winged helix domain and is responsible for their DNA-binding activity.
- Rederence
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- https://www.ebi.ac.uk/interpro/entry/panther/PTHR12577
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000350 | Abrostola tripartita | Atri021135.1 | DACH2 |
| iTF_00000351 | Abrostola tripartita | Atri021133.1 | - |