Tbar009776.1
Basic Information
- Insect
- Timema bartmani
- Gene Symbol
- -
- Assembly
- GCA_902151455.1
- Location
- CABFWB010000505.1:116636-117145[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 0.036 1.2e+02 5.0 0.0 54 84 20 50 19 54 0.79 2 6 0.078 2.7e+02 3.9 0.0 54 81 42 69 41 75 0.77 3 6 0.047 1.6e+02 4.6 0.0 54 81 64 91 62 98 0.78 4 6 0.2 7.1e+02 2.6 0.0 54 72 86 104 84 108 0.84 5 6 0.029 1e+02 5.3 0.0 54 72 108 126 106 130 0.85 6 6 0.08 2.8e+02 3.9 0.0 56 81 132 157 129 165 0.77
Sequence Information
- Coding Sequence
- ATGACTGTTATTCTAAGCGAACAAGCAAGGCAGGGCGGGAGTGAAGGTAGACTCTTGACCCTGTCTGTAGATGACTGTTATTCTAAGCAAACAAGGCAGGACGGGAGTGAAGGTAGACTACTGACCCTGTCTGTAGATGAATGTTATTCTAAGCAAACAAGGCAGCACGGGAGTGAAGGTAGACTCTTGACCCTCTCTGTAGATGACTGTTATTCTAAACAAGCAAGGCAGGACGGGAGTGAAGGTAGACTCTTGACCCTGTCTGTAGATGACTGTTATTCTAAGCAAGCAAGGCAGGACGGGAGTGAAGGTAGACTATTGACTCTCTCTATAAATGACTGTTATTCTAAGCAAGCCAGGCAGGACGGGAGTGAAGGTAGACTATTGACCCGCTCTGTAAATGACTGTTATTCTAAGCAAGCAAGGGAGGACGGGAGTGAAGGTAGACTCTTGACCCTGTCTGTAGATGATTGTTATTCTAAGCAAGCAAGCAAGGCAGGACGGGAGTGA
- Protein Sequence
- MTVILSEQARQGGSEGRLLTLSVDDCYSKQTRQDGSEGRLLTLSVDECYSKQTRQHGSEGRLLTLSVDDCYSKQARQDGSEGRLLTLSVDDCYSKQARQDGSEGRLLTLSINDCYSKQARQDGSEGRLLTRSVNDCYSKQAREDGSEGRLLTLSVDDCYSKQASKAGRE*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01444534;
- 90% Identity
- iTF_01444534;
- 80% Identity
- iTF_01444534;