Tlin009640.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Thymelicus lineola
Gene Symbol
MBD-R2
Assembly
GCA_963932265.1
Location
OZ010685.1:15113288-15130126[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.7e-16 5e-12 46.2 0.0 4 59 905 964 902 981 0.85

Sequence Information

Coding Sequence
ATGGTATTTAAAAAGTGCTGTGTTGCGAAATGCAAGTCAAAATCTACTCGCAAGGAGGACGTTCGAGTAACGTATCACAAGTTTCCGAAAGATGTTTCAGTTCGCGACACTTGGGTCAAAGTTACACGGACGCATGACGTTGATCGCAATAAATATGTGTGCAGTAGACACTTCTTGTTGACTGACTTTCACCACTATCAGGGCAGATATGTCCTGAAGTCAGGTGCAGTACCCAAAGTTTTCCCGTGGACAAAAATGGATGAACTAGACGCACTTACAACTGTAGAAGACACTGATCATCATAAAAGAAACCTTTCCACAAGCAGTAAAGAGTCTGAACCAGAGAATTTGGAAGCCATAAAAGATTTCATAGCAAAACatgagaaaaagaaaacagataATATGGAAACTCAAAATGGGTCTCAAAAGACAGATGACATTACAATAGAAATAGATGATAGCACAGCTGAATCTAGCATCCAGAGTGATAAAGATGAGACATTGGCAATTGCCTCCAGCGTTATGGATTTAATATTCAATGAATCTACTGACAAGTTGTCAAAGAATAATGAATCTACCTCACATTCTTCATCCATGGATAAAGGTACAACCAGTGTTGCATTATCTGTTGGATCAAAAGTAGAAGCGAAAGATTTTGCTGAGAGCTGGTACACCGCTGAGATAGTCGAGGTTGATTATGATGAGATGGAAGTCTTAGTACGCTATGATAGTGTAACCAAAAAgTCTGAGGAATGGATAAGTGTCAGTAGTCCAAGGCTAAGACCAGTGACTGGAGAAATTAAGTCGGGTGAAATTAAGTGTTCAATATCAGCCGCAGATGAAAAAGCTCAGAAGATGAAACCAACCAAGGTGACTGCGGAGACACCACCAGTCAAGGAAGAGGAGAAAGTTGAGGATAAACCGAAACTGGCGTTTGCAGTTGGAGAACGATGTCTAGCACGATGGAGGGACAATCGCAGATTTGTTGCTACCATACAAGATGATTTAGGGGATGGTACATATGCGATAGCTTTCGACGATGGATTCCACTGGAAGTGTAGCGTTAATAGGTTGTCGAAGTTGAAGAGTTCTCACTTAGACTCCCGTGCTTGTTCCACTCCGTCTCCTACTCCTGGCGCTGGTCCCAGCACTTCTACAGCCGTTAATCCCATGCCTGCGTTCCATACACATCTCTTTGATCCAACACGTGACTATTTGGGCTCCAAAAGCGAGCGACGGGAACAGAAACGCAAATTGAATATCAAGGAGATTTTTAACATTGGACAGAAACAACGCAGAAAGGATGCGCCGGTTAAGGATCAAAGGCCTAAAAcaccaaaagaaaaaaaaccaagAATCCTCAAGAGCAATGTCAAGGTCGAACCTAAAACAGAAGCAGAAAAGAAGGATATTCCTGATGCGATTGCATCAATAATTGGTATGGTTAACAATGAAAATGTTGGTGTTAAGAAGGATTCGGTAgatgtcaaaattaaaaaagaaaagacGAAAATTAAGGAAGGACACAAATATTCTCTATCTGCGGATAAAAGAAATTCTAAATCTAAGCATAATCAATCTCAAAaagatgatgatgaaaatttgGAAAGTATTGGAAAGAAGAAAGCTGAACAAACATCCGTATTAAACGTATCAGATGAAGACACACAAAGTGCAAAAATGTCTGATACAGAATTTGACACATTTGATGATCAAGATGATGTGAATACGTCTGGAGATCAAGATGGAAAACTTTCAGATGATCCAGATGGGAAAATGAGCATTGATAAGATTCAAGAAGAGGATAAGCTGCAGAATTTTGAGAAACTTGACGATGTTGTGCACGAACAAGTGATGGATCGTATAAAGGAGGCCATTATTAAATTAGAGGATGGTTTGAATAGAGATCTTAATGCCGGCTCACCTAAAATAACTAGAGAATTTAACCCCGATTCACCTAAAGTGAATAGAGTATTTACAGTCGACTCGCCTAAAGCGAATGTGGAACATGACACCGAGTCAACGAATTTGAATGTAGAGCAACACGTTGATTCGCCTAAATTCAATACAGAACTGAATGTTGTTTCGCCTAAAGTTGAAACAGAACAAAATATTGATTCACCTCAAGTGAATACAGAATTTAATGTTGATTCGCCTAAAGTGAATTTAGAACTAAATGCAGATTCTCCGAAAGTAACTGCAGAACATAGTGTAGAATCTCCTGAAGCTACTGTACAAATCACAGATCAGCCTGAAGTGAAAGAAGAACCTAACGCTGAATTATCTAAAGTTGATATAGACCCTAACGCAGTTAAATCCGATCCAGTTAAATTGGAAACAGTGAAAGAGGATCCAGAAAAACCAATTGTGAAAGAAGAGATAAAACAAGAGCCAAGCACAAGTAAAATAAAGAAGTCGAAGAAGAGGTCCAAAAACCTTCTGAAGTTAGCGCAAAGAATAAGGGTGCTAGGGCAGGACGATCCACCGGGATCCGTGGTGGAGATAAACACTAAAATAGAGCACATAAAGAAGGAAATGAAAGAGATATTGATGATGTTTGAGAAGGAAGTGCCTGATAAGGAGTCTGAAGCCCCTTCGGAAGGCGAGTGGTGTTGTAGATGGGTGAACGGGGAACCTGTGGGTACCATTGTTGAAACAGAGCCGGATAATAGAATTGATGTTCTCAACAGAATTGCCTTGCCACGGAAGACTGTGCAGGTTGAAGACAAGAGACTCCCAGAGGGATGGACCAAACTTATGGTCCGTAGAAGTTTTGGTCACTCGGCAGGAAAGTGGGATGTTGTTCTTGTTAGCCCAGACAAACGTCGATTCCACACGAAGACAGACATGCGACATTACCTCGAGAACAATCCGGACCCTTCGCTGAAGAGCTACGAACCAGCGTTATTAGACTTCGCGGTTCATCTTAAGCTGGCCAGGCGCATGGGCTGGGTGTCTGGCGATACTGGCCATGCGAGCCGCAGCTTGGTCAATAGACCCCTCTCGAGGAAACGGAAGAAGCTGATGCTTAAACGTGGTGATAAGGAGAGGAAGGTGAAGAAACGGAAGCTCAGTGCTGATGGCAGGTATAAATATGAGCGAGTACCAGTTCCTGGGACAAGTGGTTCTTCTATAATGGATTCATCTGGCAATATATCTTTCAACAACTCCACACTTGAGGATGGATATGTATACGTGGGATCTTTAAAAGTGCAAGTGATCGAAAACCTGCTGCGATGCCCAGCGGAAGGCTGCTTCAAGAACTTCAGAAACAACACGCTCCTTCAAATGCACATCAAACATTACCACAGGGAGTTGCGTAAGTCTCTCGGCGCCACTCCCAAGGTATTGGACCTCGCGTACGCCAGGACAATGCCCACAGAAACTGAGACCAGACGTCACGAGCCAGACAATAAGATCATTAAAGTTAAGATTAAGCCACCAAAGAGAATCGAGGAGAAACTTGACATGAGGGAGATTAACATCGACCCGAGGGGAGATATTTCGAGCCCCATTCGAACACCCAGAGAGGAGAAAATACCTCGTTCTTTAGATTCTCCTATCATGCGTCAGTTCGCGCTTCAAGCTAGTAGTAGCAATGGCAATAGAACGGTAAAGAGACCGAAGGTATTGCTACCGGTGAGAAGACCGGAGCCTGTTCAGCTGCGACCTGAGTTGGAGCCAATTAATGACCTTCCTGATTTCTCGTTTGATAACACCCCAATTGAGCCAAAAGTCATAGTGCCGCCACTTCCAACTTTGGACTTCGAAACGGCAATCTCCACTCATACGGTCTCGAAGCCAGAGTTTATGCGAAGGGCAGAGAAGCGAAAGGTGTTTGCGACGATTTCGAAGGCACCATTGAGTGAGGATGAGGAAATGACAGGGATGACCTCGGATCTGGACCTGGACACGAGGTCCAGTTTCCCTGGTTCAGGGACGCCAGATTCTAAGACCATGGAGCCGAGGGTCCCTGCGCAGAACATACCAATGTCGTCGGAGTCCAACGAAGATTCtgctatgtatatgtatacagagACGGGCGAGCGTATAAAGCTTGAGCGTATGAAACGGGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGTTGGCAACACGCGCTCTGCCACAACATACAGCGGGAGGCCGATGTGCCCCAAAAGTACACATGCTCAATCTGCCTGAACCCGCGTCGGGGGCGGCGCTCCCAGCGGTTCCTGCACGACCAGGACCGCATGGCGGAGGGCCGGTTGCCGGGCGCTCCGCCCTCGCGCCCGCTGCGCCGCTCGCACGCGCTCTCCGCCAACCTGCTCCACGTGGCCGATGCGTTGCACGCGCTGCGGGTCAAATACTATGTCGCTACCAAGAAAAATCACCCGAAACTGTACCTGTGGGCCAAAGACTGGGACGCTCCCGAGCCGTTCGCTCAGGACAAGCCGAACTACTCCGATCTGAGCGTCATCATCAACAACATGAGCAAGAACAGGAGCGAGCGCGTGGACGTGACGCCGACGGACGACAACGAGGACAGGTTTAGCCAGAACGGGTCGTTGAGCAACCATTCGTTGCTGGGAGGCCTCCTCGCGAGCCCCGGAGGACCCTCGCTCGAGATGCCCATCAGTACTACTGAGCTGGAACGGCTCGCGAAGTCTGTTCAAGaACAAGTAGAGGCCCGGGCTCCGGTCCCGGTGGTGCCGCAGCCCGAGGCGGCCATCGAGAATGGCGCGTGTCGCGAGCGGCTACTGCGCCACGTCCAGCGTTGCCAGGCTCTCATCGATGCCCGGCTTGACACGCTCGAGGCAGAGATCATTGAACTGGAGTCTCAAGACCCATCGTTCGAGGATGACGAAACAGCAGACTACTTCCCGCGCACCAAGCAAACGGTTCAGATGTTGCTGCGGGACCTGCAGACACTACAGCAACTTGGCCTCGTTACCTAG
Protein Sequence
MVFKKCCVAKCKSKSTRKEDVRVTYHKFPKDVSVRDTWVKVTRTHDVDRNKYVCSRHFLLTDFHHYQGRYVLKSGAVPKVFPWTKMDELDALTTVEDTDHHKRNLSTSSKESEPENLEAIKDFIAKHEKKKTDNMETQNGSQKTDDITIEIDDSTAESSIQSDKDETLAIASSVMDLIFNESTDKLSKNNESTSHSSSMDKGTTSVALSVGSKVEAKDFAESWYTAEIVEVDYDEMEVLVRYDSVTKKSEEWISVSSPRLRPVTGEIKSGEIKCSISAADEKAQKMKPTKVTAETPPVKEEEKVEDKPKLAFAVGERCLARWRDNRRFVATIQDDLGDGTYAIAFDDGFHWKCSVNRLSKLKSSHLDSRACSTPSPTPGAGPSTSTAVNPMPAFHTHLFDPTRDYLGSKSERREQKRKLNIKEIFNIGQKQRRKDAPVKDQRPKTPKEKKPRILKSNVKVEPKTEAEKKDIPDAIASIIGMVNNENVGVKKDSVDVKIKKEKTKIKEGHKYSLSADKRNSKSKHNQSQKDDDENLESIGKKKAEQTSVLNVSDEDTQSAKMSDTEFDTFDDQDDVNTSGDQDGKLSDDPDGKMSIDKIQEEDKLQNFEKLDDVVHEQVMDRIKEAIIKLEDGLNRDLNAGSPKITREFNPDSPKVNRVFTVDSPKANVEHDTESTNLNVEQHVDSPKFNTELNVVSPKVETEQNIDSPQVNTEFNVDSPKVNLELNADSPKVTAEHSVESPEATVQITDQPEVKEEPNAELSKVDIDPNAVKSDPVKLETVKEDPEKPIVKEEIKQEPSTSKIKKSKKRSKNLLKLAQRIRVLGQDDPPGSVVEINTKIEHIKKEMKEILMMFEKEVPDKESEAPSEGEWCCRWVNGEPVGTIVETEPDNRIDVLNRIALPRKTVQVEDKRLPEGWTKLMVRRSFGHSAGKWDVVLVSPDKRRFHTKTDMRHYLENNPDPSLKSYEPALLDFAVHLKLARRMGWVSGDTGHASRSLVNRPLSRKRKKLMLKRGDKERKVKKRKLSADGRYKYERVPVPGTSGSSIMDSSGNISFNNSTLEDGYVYVGSLKVQVIENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELRKSLGATPKVLDLAYARTMPTETETRRHEPDNKIIKVKIKPPKRIEEKLDMREINIDPRGDISSPIRTPREEKIPRSLDSPIMRQFALQASSSNGNRTVKRPKVLLPVRRPEPVQLRPELEPINDLPDFSFDNTPIEPKVIVPPLPTLDFETAISTHTVSKPEFMRRAEKRKVFATISKAPLSEDEEMTGMTSDLDLDTRSSFPGSGTPDSKTMEPRVPAQNIPMSSESNEDSAMYMYTETGERIKLERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQREADVPQKYTCSICLNPRRGRRSQRFLHDQDRMAEGRLPGAPPSRPLRRSHALSANLLHVADALHALRVKYYVATKKNHPKLYLWAKDWDAPEPFAQDKPNYSDLSVIINNMSKNRSERVDVTPTDDNEDRFSQNGSLSNHSLLGGLLASPGGPSLEMPISTTELERLAKSVQEQVEARAPVPVVPQPEAAIENGACRERLLRHVQRCQALIDARLDTLEAEIIELESQDPSFEDDETADYFPRTKQTVQMLLRDLQTLQQLGLVT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01438064;
90% Identity
iTF_01439009; iTF_01438002; iTF_01438064;
80% Identity
iTF_01439009;