Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.4 2.6e+02 1.5 0.1 15 46 121 152 116 158 0.83

2 7 0.65 1.2e+02 2.6 0.0 21 45 155 179 150 182 0.89

3 7 0.00044 0.081 12.7 0.0 21 46 183 208 179 214 0.86

4 7 0.0032 0.58 10.0 0.1 21 46 211 236 207 242 0.86

5 7 0.15 27 4.6 0.0 21 45 239 263 235 266 0.88

6 7 0.045 8.2 6.3 0.0 21 47 267 293 263 299 0.85

7 7 0.25 46 3.9 0.1 23 44 297 318 291 322 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.4	2.6e+02	1.5	0.1	15	46	121	152	116	158	0.83
2	7	0.65	1.2e+02	2.6	0.0	21	45	155	179	150	182	0.89
3	7	0.00044	0.081	12.7	0.0	21	46	183	208	179	214	0.86
4	7	0.0032	0.58	10.0	0.1	21	46	211	236	207	242	0.86
5	7	0.15	27	4.6	0.0	21	45	239	263	235	266	0.88
6	7	0.045	8.2	6.3	0.0	21	47	267	293	263	299	0.85
7	7	0.25	46	3.9	0.1	23	44	297	318	291	322	0.89

Coding Sequence: ATGCACACTGAACGCAGGACTTTCTGTAACCAACGTCCAACTTCTTTGAGATTAAGTAAGTCACAGGAAACAAGGCTTCGTAGAGTCACGCCACACTGCGTTCTCGTACTGGAGCAGCCTTGGCTTCGTACACTAGTTGGTGGCGCACTTGGGGCCGTGAAACGCAGCCGCAGTGTTCCCAGCGGTCCCTCTTGCCCGAGGCGGATTACCCGAAGAATAGGGCACGAGTCGGTGTGCACCGTTCCTCTCTGCACTTTGAGGTCTTCGCCTGCACCTAAGGCCCTCCCTGCCAGGCGCATCATGCCCCTCGAGAGCTCACtgtgcggcgaggtggcggcatcgtcagcggcgccgcgtgttCCACGTGGCAAGCGTGGAGGGCAGCAGGCACTCCACTGTGCAGTCTGCGAGAAGGAGTTCCGATGCAAGAGTGACCTCCAGGTGCACTTCCGagtccacaccggggagaagcctttcgagtgcacgtTCTGCGAGGAGAAGTTTGCTCTAAATGGAAACTTAACAAGGCACCTTCGaacccacaccggggagatgCCCTTCGAGTGTGTAATTTGCGAGAAGAGGTTCACGCAAGGTGGAAATCTGAGAAGGCACCTTCGCACTCACACTGAGGAGAAGCcgttcgagtgcacagtttgcaagaaGAGTTTCTCTCACAGTGGCGCTTTAAGAAGACACCTTCggacccacaccggggagaagcctttcgagtgcgaTGTTTGCCAGAAGAGTTTTGCTGTAAGTGGACAACTCCGAGCGCAccttcgcacccacactggggagaagcctttcgagtgcacagtctGCAAAAAGTGTTATACTGAAAGCGGGACCCTGAGAAAGCACTTTCGAACGCACACTGGGGtcaagcctttcgagtgctcGGTTTGCAAGAAAAAATTCGCTCGAAGTGAAAACCTCAAGAAGCACTGTCGTACCCACATTATCGGATAG
Protein Sequence: MHTERRTFCNQRPTSLRLSKSQETRLRRVTPHCVLVLEQPWLRTLVGGALGAVKRSRSVPSGPSCPRRITRRIGHESVCTVPLCTLRSSPAPKALPARRIMPLESSLCGEVAASSAAPRVPRGKRGGQQALHCAVCEKEFRCKSDLQVHFRVHTGEKPFECTFCEEKFALNGNLTRHLRTHTGEMPFECVICEKRFTQGGNLRRHLRTHTEEKPFECTVCKKSFSHSGALRRHLRTHTGEKPFECDVCQKSFAVSGQLRAHLRTHTGEKPFECTVCKKCYTESGTLRKHFRTHTGVKPFECSVCKKKFARSENLKKHCRTHIIG

Sequence clustering based on sequence similarity using MMseqs2