Basic Information

Gene Symbol
-
Assembly
GCA_947578465.1
Location
OX387926.1:2717867-2724865[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 31 0.016 0.96 10.4 4.0 1 23 198 221 198 221 0.93
2 31 0.0011 0.067 14.1 0.9 3 22 252 271 252 271 0.95
3 31 0.00023 0.014 16.2 1.0 2 23 305 327 305 327 0.97
4 31 1.4 87 4.3 1.9 1 20 344 363 344 365 0.89
5 31 2.5 1.5e+02 3.5 0.9 1 11 375 385 375 401 0.87
6 31 0.015 0.9 10.5 0.3 1 23 425 447 425 447 0.96
7 31 0.0014 0.087 13.7 2.0 2 23 494 515 493 515 0.96
8 31 0.00023 0.014 16.2 2.0 2 23 562 584 562 584 0.97
9 31 0.00024 0.015 16.2 1.3 1 23 634 657 634 657 0.97
10 31 0.00058 0.036 14.9 0.1 1 23 712 734 712 734 0.97
11 31 0.0014 0.086 13.8 6.6 1 23 745 767 745 767 0.97
12 31 0.57 35 5.5 1.3 2 23 779 800 778 800 0.95
13 31 0.0049 0.3 12.0 0.9 1 23 810 832 810 832 0.98
14 31 1.4 86 4.3 3.5 1 23 861 883 861 883 0.92
15 31 0.0013 0.082 13.8 5.6 1 23 894 916 894 916 0.98
16 31 0.002 0.12 13.2 1.2 1 23 924 946 924 946 0.96
17 31 0.0003 0.018 15.9 0.2 2 23 967 989 966 989 0.97
18 31 0.038 2.3 9.2 2.5 1 23 1007 1029 1007 1029 0.97
19 31 0.24 15 6.7 0.7 2 23 1070 1092 1069 1092 0.90
20 31 0.0041 0.25 12.3 0.2 2 23 1115 1136 1114 1136 0.95
21 31 0.4 25 6.0 0.3 2 20 1140 1158 1139 1159 0.92
22 31 0.24 15 6.7 1.6 2 23 1179 1201 1178 1201 0.96
23 31 0.044 2.7 9.0 0.6 2 23 1217 1238 1216 1238 0.91
24 31 0.042 2.6 9.1 1.8 5 23 1248 1266 1246 1266 0.94
25 31 0.0059 0.36 11.8 0.8 2 23 1277 1299 1276 1299 0.95
26 31 2 1.2e+02 3.8 6.7 2 23 1316 1334 1316 1334 0.94
27 31 4.2 2.6e+02 2.8 1.9 2 20 1338 1356 1337 1358 0.91
28 31 1 62 4.8 1.4 2 23 1406 1427 1405 1427 0.92
29 31 0.0046 0.28 12.1 0.5 2 23 1438 1460 1437 1460 0.97
30 31 2 1.2e+02 3.8 0.6 2 23 1476 1494 1476 1494 0.79
31 31 0.43 26 5.9 3.3 2 21 1498 1517 1497 1518 0.95

Sequence Information

Coding Sequence
ATGGCCCTCAAACTTGGAAAATGCAGGCTCTGTCTCAAACTGGGAGACTTTTATTCCATCTTCACGGCGGATAATGATGTCCAACTGTCCGAGATGGTTATGGATTGTTCCAGGATAAAGGTCTACGACGGAGATGGCCTCCCTGATAAGGTGTGCTCCGAATGCATTCAGAAGCTCAGCAGCGCCTACATATTCAAGCAGCAATGTGAGAGGTCTGACCAGGAACTGCGGCGCAACTATGTCCCGCCCCCCGGATTCAGTATCAGTCCTCCACCACCCATAAACCGGCAAAGTAGCGATTCTGCCTTCTCAACCCAAACAGACAGCTCAAACCTAAAGACCTCCTTTACCGAAAACAAAGTAACACCCGTCAGCAGGACCAGAAAGAGGAGCGTCGAAAGTGACACTGCTTCCGTCGGCAGTAGGTCCCAAGACAACAGTCGACCCAGCAGCTCCAAGAGGGTGGAGGAACTCAGGAAGTCACAGAGACCAAAGCGACCACGTTACTCCGCCGACTCCGACTACGAAGACCCCGGAGGCTCCAGCTTCATCAACGAAACAGATTCAGATGAGCCGCTCCTCAAAAATGAGCATGCATGCCCTCACTGTCCAAAGACCTTTAAATGGAAGAAAAGCATGAAGATTCATATGGCCCATGTACATACCGGGAAGAAGGCAAACTCGCGACAAGAGGTTGCGGTCAATATTCCGGTTAAAACCATGAACCCACCTGACAACGATGATCAGATTGGCTGCGAGAAATGTGGGAAAAAATTCAAACTAAAGATCATGCTAAAACGTCATCAAGAGACGTGCCAAGTATCATCAGTTAAATCACCACCAAAATCACCCATGAAAGAACTGGTGATCACTCTAGAGCCGATAGACGCCAAGACCCGCAATAAGAAACCAACATGCGAGTACTGTACGGCCCACTTCAAAACTGTGGAAAACTTGGAGAAGCATCTCAGAGTTGTCCACGCGGCCACACGTAAGAAATCGGTAATCAAACCTAAACGTATAGGACATTACATATGCAATTTTTGCAAAAAAGATTTTCCCCATTATTTACTATTAGATAGTCATTGGTGCGGATGTATGATGAGGTCGAACCTGAAAGTTTACGATTGTCCGATGTGTCCCCAGGTCTTTAAAGGTGAAAGAGCTGTGGGCGATTATGTGCGTCATATGAAGGGGGTTCACTATCCCCCCTCAAAAGAGGAGACTTTATTTACTCGGTTCGAGAAGCGGCCGGAAGATCTTGAGCCGTCTTTCGAGTGCCGCATGTGCAATAAGAAGCTGGCCACGCAGTTCCTACTGGTCAGCCACTTAGCCGAGCACATGTCGGGGGTCGATGATAATGTCACTGTTGATGATGATGATTTCGATTCGAGAGATGACGCAGTAGCTGATGACGCTATGTCAATTCAGTCTGCTCAAAGCTCTCAAGCCTCACAGGCCTCACATTCGGGGCCCGTCAAGTGCCGCTTCTGTGACAAAGAGTTCAAGTACAAAAAATCCCTCATCTCACATGAACTGAAACACACCGAAGATAAAGTACCAGCTGTAAAAATCGAGCCCCCAGACAAAGTACCAGATGCGGACCTACTCACGGAGAGTAACGCACAGTATTCTAAAGAGTTCGACTCTGAATCTAGTCAAGACGAAGGAGAAGAAGACAACACGTGCGATATTTGCGAGAAGCAGTTCTCCTACAAACGGCTGCTTATCCAACACAAACGCACGAAACATACGATGGTAGCTGGTATGAAGCGAGCGAAAATAAGCCTTAAAGACTGCTCGGTAAGATGCCTGATATGCGAGGAGGAGATGAAAGTGAGCGCTATCAATGAGCACAATCAAAAGCATATTTCAGTGAATATTCGGCCGAGGAATATTTACACTTGTGCAGAGTGCGCGCAGAAGTTCAAAAGCTGCAGTAACCTGGCTAATCACATCAAGCTGGTGCACAGGTTGAAGCAGCAAGAGGTGCCAAAGCAATTTGCAGGCGTGGATATGGCGGATTTTTGTGAAGTCGTTGTGACGAAGGCGGAACCCCTGGACGAATCCCAGAGTCACAACGGCTTTGGAGAGGTTCCGCTGAAAGCAGATGCCACGGTCAACCTTAGTGGGTTCACCTGTCCCATCTGTGGGAAGAAGATGCCCACGCTCATTTCGCTCAAGCGGCATGTCAACTGGCATTCGTTTGTGGGAAATAATTTAGAGTCGAAGCACGAATGTTTCGTGTGCAAAGAGACCTTCAAATTCAAAGGTCACTTCAAGGTCCACATGCGGCAGCACTACAGAGACACGAACCTGGACCCGGCGCTGCTGACGTGTTCCATCTGCCAGCGCAAGAGCAAGCATCTCCGCGCCGCACAAGCGCACACCAACTGGCACAAGCAGACGCGCTTTCAGACCAAGGACTACCAGTGCTCCATATGCAAGCGCGTCTTCCAGTACCGCCGCGTCTATCTCTCGCACATGGCCATCCACTACAAGAAGGGAGAGAGCGGACAGAACACTATAGTCGGCAACATGGCCGACAATAATCTAGACAAGGCCATCTTCGACGGCACCTTCAGCTGCGAGTTGTGCGGCAAGATCTGTGATTCGGAAAACTCCCTGAAGTGCCACACCAGCTGGCACAAGTCCAAGACGCTGCTTTACGGCGCGCGGCACGAGTGCCAGATGTGCAACCTGCAGTTTACCAACAAGCGGCATCTCGAGCTGCACACGCGCTCGCACTACGAGGACCCCGACGGAGAGTTCAAGTGCAACATCTGCGGGAAGGGATTCATCGACGAGGAGTACCATCGGCGGCATGTCAAGGGACACAACTTCGACAACCAGTCAACCAACAAGAAGAGAATCGAAAATCTCAGAAAGGGCAAAGTGAAGTGTCCCATATGTAACCGGTACTATCCGGATCTGGTGAAGTTGATCCGCCATCTGCGACGCACGCATCCGGAGAGCAAGATGATAAAGGAGGACCCCGACGCGCCGCCGCGGAAGTACTACTCCTGCAAGCTCTGCGCCAAGTCTTTCTTCGACGAGAAGCGGTTCAAGCGCCACGAGGAGTCGCATCTGCGCAAGCCGAGCTTCTTCAAATGCAAGTTCTGCGGCCACAAAACCATATCCATGAAAGGCCACCACATTCACATCAAAACTAAACACATGACCAAAAAGTATGTGGACAATCCTCTGAAGTGTCCGAAGTGCGAGGAGGTGTTCGTGTGGGGATACGCGCTGCACCACCACCTGCGGGACGAACACGGCATCAACGAGGAATGGATCGCCGAGCGCACCGAGGCCACGCTCGAGGGCCCGCTCAAGGACCTGCAATGCTCCGTGTGCCTGAAGGTCCTCGCCAGCAAGGGCAACTTCGAACGCCACATCGACTACCACAACACTCTGCGCTGTAACTACTGCTTCGAGTACTTCAGCACGCTTCGCTTCCTCGAAGGCCATCTCGCATTCAGCTGCGATAAGAAGACGCTGATCGGAGACGCGGACCCGCACACGAAGCGCATCAAATGCGAAGTATGCTACAAGGCGTTCAGCTTACAAGTCAAGTTGGACTGCCATCTGAGAACTCAGCACAGTATCGTTGTGAACAGGGAACAGTTGGCCGGCAAGCAGGAGCTGGTGTGCGACTATTGCTTCAAAGTGTTCGAGAACGAGCACGCACTGAGCGGACATAAGGTCTATCACCGCACCATCGGTTATTTCGGCTGCATCTATTGTCCAAGGAAATTCAATACTCAAACGGCGTACAGAAAGCACAAGAACAATCACTTGTCTGTTCATAACGTAGAGAACCCGACGAAATGTGATCACTGCGACGAAACCTTCGTGCCATTCAAGGAGATGATATACCACATGCGTGACGTGCACGGCGATGACAAAGAATGGATCGTCTTCCCGAAAGATTCCATCGAGGAAACGTGCACTATCTGCCACAAGACATTCTTCAACCTACACAGGCACATGGATTATCACGAGGAGAACAAGTGCAAGAAATGTAACGAATACTTCTTCTCGACGGTGGATTACGACAACCATCTCTGCGCTATCGAAAGCGACGTTGAAGAAGTTGCAGGTGTGGTCAACCCCGGAATGCCATACGAGGAATGCACGTTCTGCTTCAAGCCAATCACCAAGAAGGATTCCAAGAAGAAACACGACATTCTACATCGCACTTCGGGAGCGATTTCTTGTCGATTCTGCTATCTGAAGTTTAAAACCCTTGACGCGTTCAATATACACTCGTTCTCTCACCGCAGCAGGAAATATAACAAGAAGCCAATTAAATGCCGCGTCTGCAAGGAGCGGTTCGTCAAGTATGGTCCTTTTATAAAGCACATGAGAAGCGTACACAAAACTGCCAAGAAGACCCACTACCGCGCGCTCGTCAAACCGGAACGTTGCGTTATCTGCGGCGAAGAGTTCCCAAACTTGCACAACCACTACCGCGCACATTTAGCCAATCAGTGCCAGTTTTGCCTCAAATACTTCACCTCCTCCAAACTTTTCGCAAAACACCAGTGTGATGTGATCGACGAAGATAGCACTAAAGTTTTTACTTCAGATGAAAACTTGATGGCGCTCATCAACTCTTACGTTCCTCGAGACTTGAAGGATGATGAGAAATTCTACGGTTACACTGACGACGATGAAGAGGTTGAGACCGCTCTGCCGGTAGCGATGACTCAGGCGCAGGATATGAAGGCTTTGAATGGCCCGACGAGCCTTAAGCCAGTGCAAAACAGCCAAGAGGTTGAGTTCGAGAGGGACCTTCACATGATGGTGCAGTCGCCGATAATATCCGATGTGCTATCATTATTCCAAACGGAAGAGGAGACCCAGGACAGTAAGATTGAGATGGGAGACGTTTTTAGTGTGTCCGATGATTCCATGGATATGAACGATATTGAAGCGCCCATCGTTGTAATTGATGATTAG
Protein Sequence
MALKLGKCRLCLKLGDFYSIFTADNDVQLSEMVMDCSRIKVYDGDGLPDKVCSECIQKLSSAYIFKQQCERSDQELRRNYVPPPGFSISPPPPINRQSSDSAFSTQTDSSNLKTSFTENKVTPVSRTRKRSVESDTASVGSRSQDNSRPSSSKRVEELRKSQRPKRPRYSADSDYEDPGGSSFINETDSDEPLLKNEHACPHCPKTFKWKKSMKIHMAHVHTGKKANSRQEVAVNIPVKTMNPPDNDDQIGCEKCGKKFKLKIMLKRHQETCQVSSVKSPPKSPMKELVITLEPIDAKTRNKKPTCEYCTAHFKTVENLEKHLRVVHAATRKKSVIKPKRIGHYICNFCKKDFPHYLLLDSHWCGCMMRSNLKVYDCPMCPQVFKGERAVGDYVRHMKGVHYPPSKEETLFTRFEKRPEDLEPSFECRMCNKKLATQFLLVSHLAEHMSGVDDNVTVDDDDFDSRDDAVADDAMSIQSAQSSQASQASHSGPVKCRFCDKEFKYKKSLISHELKHTEDKVPAVKIEPPDKVPDADLLTESNAQYSKEFDSESSQDEGEEDNTCDICEKQFSYKRLLIQHKRTKHTMVAGMKRAKISLKDCSVRCLICEEEMKVSAINEHNQKHISVNIRPRNIYTCAECAQKFKSCSNLANHIKLVHRLKQQEVPKQFAGVDMADFCEVVVTKAEPLDESQSHNGFGEVPLKADATVNLSGFTCPICGKKMPTLISLKRHVNWHSFVGNNLESKHECFVCKETFKFKGHFKVHMRQHYRDTNLDPALLTCSICQRKSKHLRAAQAHTNWHKQTRFQTKDYQCSICKRVFQYRRVYLSHMAIHYKKGESGQNTIVGNMADNNLDKAIFDGTFSCELCGKICDSENSLKCHTSWHKSKTLLYGARHECQMCNLQFTNKRHLELHTRSHYEDPDGEFKCNICGKGFIDEEYHRRHVKGHNFDNQSTNKKRIENLRKGKVKCPICNRYYPDLVKLIRHLRRTHPESKMIKEDPDAPPRKYYSCKLCAKSFFDEKRFKRHEESHLRKPSFFKCKFCGHKTISMKGHHIHIKTKHMTKKYVDNPLKCPKCEEVFVWGYALHHHLRDEHGINEEWIAERTEATLEGPLKDLQCSVCLKVLASKGNFERHIDYHNTLRCNYCFEYFSTLRFLEGHLAFSCDKKTLIGDADPHTKRIKCEVCYKAFSLQVKLDCHLRTQHSIVVNREQLAGKQELVCDYCFKVFENEHALSGHKVYHRTIGYFGCIYCPRKFNTQTAYRKHKNNHLSVHNVENPTKCDHCDETFVPFKEMIYHMRDVHGDDKEWIVFPKDSIEETCTICHKTFFNLHRHMDYHEENKCKKCNEYFFSTVDYDNHLCAIESDVEEVAGVVNPGMPYEECTFCFKPITKKDSKKKHDILHRTSGAISCRFCYLKFKTLDAFNIHSFSHRSRKYNKKPIKCRVCKERFVKYGPFIKHMRSVHKTAKKTHYRALVKPERCVICGEEFPNLHNHYRAHLANQCQFCLKYFTSSKLFAKHQCDVIDEDSTKVFTSDENLMALINSYVPRDLKDDEKFYGYTDDDEEVETALPVAMTQAQDMKALNGPTSLKPVQNSQEVEFERDLHMMVQSPIISDVLSLFQTEEETQDSKIEMGDVFSVSDDSMDMNDIEAPIVVIDD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01170802;
90% Identity
-
80% Identity
-