Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_947397855.1
Location
OX377610.1:65342875-65347248[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.6e-22 6.7e-19 67.5 0.1 3 76 421 492 419 493 0.93
2 2 0.77 3.2e+03 -2.0 0.0 45 63 927 943 926 951 0.81

Sequence Information

Coding Sequence
ATGGGTCGCCGGTGTTGTATTGCTGGCTGTACATCAAATTCACGATTGCCAGAACATCATGGTGTAACCTATCATTCATTTCCAGCTGACCAAAACTCACGTTCTATTTGGATACGGAATACCAAAATAAATACAGATCGCCACATTACCAAAAGTGTTCTAGTGTGCTCCAGACACTTCCGGCGCGCTGACTTTCAGCCGCAACGTAGCGGTAAATATCTGTTAAAACAAAAAGTATTTCCTACAGTGTTTCCCTGGGGTAAAATTGATTCTGCACAAATTGAAGAAGATTTAGAATTTTTAAATTCTACAAGCTCAGGAGCTCCAAGTTCTTTGTTGACTACATCCAGTGCAGTAGATGAAGATACAAAAGCTACTGTAGCAGCCACAGTTGCTCAAATAATGGCGCAAACTGCTGAATTAAATGCTGCGGCAGGCATTAAGATTGAAAAGACGGAAGATGGCTTAGAGGAATTGCAGGCCGATACTACGACAGCTGCTGTGCTGCCTACAGCCGTAAGCATTAAATACGAGCCGGTAACGTCCTTTAATCCGGGTGCCCGTTTAGAAGCTCAAGATTTTGATGGGGTCTGGCACACAGCTCGCATTGTTGAAGTTGACAATGACGATCGCGAGGTGCTCATCAAGTTTGAAAAAAATAGTAAGAATAAATCCAGCATTGCCGGCACAGAGGAATGGATTCCTATGAATTCTACACGTTTGCGACAGCGAGTGTCCAATAAGCCCATATTGAATTTCGAATTAGAAGAGAAGTGCTTGGCCCGTTGGTCCGGTCCACGTAAATTTCCTGGCACAGTTAAGAAAATTCTTCCTAACGATGCTTATGAGATACTGTTTGATGACGGTTATGTTAAAAATGTTCGGGCTATTCATATGAATAAAGTGCCCCAACAGACTGTCCTGGAACCAGAAATTATAGAGAGCGTATCGGCAGAAGTAGTTTCGGTTCTACCTGTTGTGCCCTCTACAAGTACCCAAAGTTCTGGCACTTTAAGCACAACACCTTCAGTTTCAGCTGTAAAAAGACCATCTTCTGGTCAAAACTCTGGCTCTCATCCCAAGAAAAGAACTGTTGGTAGCTTAAGAAAAGATTGGCCGCTCTTGGACTTATCAAAATTGGATTTGTCCTCTTTAAATCTTCCCGAAATTCCTAAAGATGGTGAATGGACCTGTCATTGGGTTAACGACCAACCCATAGGCCGTGAAGGTTATTTAGTAGTTGGAGAACATCGTAAACCCACAGTTATAGTACAAGATTGGCGTTTGCCTCCAGGCTGGATAAAGCATATGTACCAGCGGTCTAATGTTTTAGGAAAATGGGATGTTATTTTAGTAACACCAAATGGCAAACGTTTCAGGTCAAAAGCAGACCTTAAAACTTATTTGGAAGATCTGGGTCAAGTATATAATCCGGATATTTATGACTTCAGCATACATCGCCGTAGAGCGAAAGATATCAATTGTTATGTACATACTGCTGACTATAAGCCGCAGCAGCCGATTAAAATCAAATCGGCATTACATTCAACCTTAGACACAACTTTGGAGACCAAATCCTCATCTATGGCAGAAACTTTACCGACTGGCGTGTCACCACCTTATATGGATACACCAATAGCGGAACCTTTGCCTCCCATAGAATTGTTAACAACTTCCTCAAATAGTTTGGCCGCTGAAGACAAGAGTGTTACACAAGTGGAAGCTGAAGTGCCAAAACAACTTTTAGAATCGGCCGAAGTAAGTTCGACGCCAACTCCAACCTCTACACCAACTGTAGGTTTAAAAGAAGAGCCAGTCATTTCGTCTGATGGTGGTACTCCCACACCTACTGTTCCAACACTAAAAACTTTAGAAGTTCCCCAAAATGTGGAAGATGGTTATGCTCTTATTGGCGGTTTGAAGGTGCAAATTATAGATAATCTATTTCGCTGTCCCCAGGAAGGTTGTTCAAAGAATTTCCGTAAAGAAAATCATTTGCAAATTCACGTTAAGCACTATCATCGTAATTTAATAAAATTACTTGGCTCCTGCCCTAAGATGCAGGAATTGGCAGAAAAACGAACACACCCTGTCAAAAATGAAACAGCTGAACCAACACCTAAAAATCAAATTCCCAATCAACAATTCTTTGCTAAATTACATCAGCAAGATCTTGAACAAACCAGGGCACATCGTAGAAGTACTGGTATTTTAAAAACCAAAGACGATTTGCCACCAGTAGAAATTAAAACGGAAACAATCGACGAAAGTACTGTCAAAGTTGTGGAAAATTTACAAAATATGAACACCTCTCACAATGATACGTCGATTAATAACACCACCGCTGATTCTAGTGTACTTATGGAAAGCTCTTTTGCATCTACTAGTGCTGCCAATGATACAGTAGTCACCGAAGCGAGCGTTAAAGGACCGACTCCAAGTAACAGATCTAGATTTTCACCCAACAAAAGAACGTCTGGCTCCCGAAAAAGTAATCGACAAAGAACTACAAAAAAATATCTCACCGCCGCTCAGGCTACAGCTGGTATAGTGAGTTCTACAACTCCATTGTCAGTAACTGCAGATTCTAGTTTCAGTGTTGTGACTGAGTTTGAGGAGACACGTCACTCATTTAATGCTACACCTGAAATAAATAAAGATGTTAAAAAGCGTAAAACTGTTTTAACTTCAAATACTCCTCTCAGCAGTGTTGATTCTCCCATAACTGCTGACTCCGGCTCAAATTCTTTCCAACCACAAAATTCTGTGGAGAATGACACAATTAACCAACTTCCCCAGTATATCAAAGAAAATGGTGAATTAATAAAAATTGTACACATGCGCCAGGAGGAAATTATCAATTGTTTGTGTGGCTACTGTGAAGAAGACGGTTTAATGATACAATGCGAACTTTGTCTCTGTTGGCAACATGGTCTATGCAATGGCATCGATAAAGTTTCACAAGTACCGGATAAATATGTGTGCTATATTTGTCGTAATCCACAAAGAGTACGCGAATCTTTACGTTTCAAACATGATCAAGATTGGTTATATGAAGGCAAACTGCCAGTTGCAAATTATCATGCTTCCAACTCGAGTCAGCTAAACAAAAGATCCGAATATCTGAAACGTTCACATATTCTAACTGGAAATCTTTTGGAACTTAAAAATTATATGCATTCTTTACGAGTTAAAATCAATATAGCCAATAATAAATGTCATCCAAAACTTTATCTGTGGGCTAAGAAATGGGATGAGGATGTAGTCTGCGACATCAAAAATGAAATCAAATCCGAAATAGAAGAGGAAAATAAAACTAATAATGCTAATTTGCTTCTAACACCCTCAAAAAAAATCAAATCTGAACCCACTACCCCAGCAAAGCTTGTACCAAATATACCGCAACCGGAAGCTCCCATTGACCCAGTAGAATGTCAGCAGCGCTTAATGGAGCATATTAAAATCCAACAAAAATTAGTTATGAGTCGTATAAACAAAATTGAAGCAGCCATAGACGTTTTGGAAAGTGAAGATGATTTGCCGGATTTGCGTGAAGAAGATTTCGGGGCTACCAAAGATGCTTTGGCTATTTTCATCAAAGATTTGGATACAGTTAAACAAATTGCTAAACTAAATAGCTTGGAACATATAAAATTAGCCTGTAAAAATCCTATTCCACAAGTTAAATAG
Protein Sequence
MGRRCCIAGCTSNSRLPEHHGVTYHSFPADQNSRSIWIRNTKINTDRHITKSVLVCSRHFRRADFQPQRSGKYLLKQKVFPTVFPWGKIDSAQIEEDLEFLNSTSSGAPSSLLTTSSAVDEDTKATVAATVAQIMAQTAELNAAAGIKIEKTEDGLEELQADTTTAAVLPTAVSIKYEPVTSFNPGARLEAQDFDGVWHTARIVEVDNDDREVLIKFEKNSKNKSSIAGTEEWIPMNSTRLRQRVSNKPILNFELEEKCLARWSGPRKFPGTVKKILPNDAYEILFDDGYVKNVRAIHMNKVPQQTVLEPEIIESVSAEVVSVLPVVPSTSTQSSGTLSTTPSVSAVKRPSSGQNSGSHPKKRTVGSLRKDWPLLDLSKLDLSSLNLPEIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEDLGQVYNPDIYDFSIHRRRAKDINCYVHTADYKPQQPIKIKSALHSTLDTTLETKSSSMAETLPTGVSPPYMDTPIAEPLPPIELLTTSSNSLAAEDKSVTQVEAEVPKQLLESAEVSSTPTPTSTPTVGLKEEPVISSDGGTPTPTVPTLKTLEVPQNVEDGYALIGGLKVQIIDNLFRCPQEGCSKNFRKENHLQIHVKHYHRNLIKLLGSCPKMQELAEKRTHPVKNETAEPTPKNQIPNQQFFAKLHQQDLEQTRAHRRSTGILKTKDDLPPVEIKTETIDESTVKVVENLQNMNTSHNDTSINNTTADSSVLMESSFASTSAANDTVVTEASVKGPTPSNRSRFSPNKRTSGSRKSNRQRTTKKYLTAAQATAGIVSSTTPLSVTADSSFSVVTEFEETRHSFNATPEINKDVKKRKTVLTSNTPLSSVDSPITADSGSNSFQPQNSVENDTINQLPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMIQCELCLCWQHGLCNGIDKVSQVPDKYVCYICRNPQRVRESLRFKHDQDWLYEGKLPVANYHASNSSQLNKRSEYLKRSHILTGNLLELKNYMHSLRVKINIANNKCHPKLYLWAKKWDEDVVCDIKNEIKSEIEEENKTNNANLLLTPSKKIKSEPTTPAKLVPNIPQPEAPIDPVECQQRLMEHIKIQQKLVMSRINKIEAAIDVLESEDDLPDLREEDFGATKDALAIFIKDLDTVKQIAKLNSLEHIKLACKNPIPQVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01174299;
90% Identity
iTF_01427516;
80% Identity
iTF_01427516;