Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7.8e-36 1.2e-32 112.6 0.0 1 84 72 154 72 157 0.96

2 2 0.58 9.2e+02 0.8 0.0 70 87 243 260 233 261 0.76

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7.8e-36	1.2e-32	112.6	0.0	1	84	72	154	72	157	0.96
2	2	0.58	9.2e+02	0.8	0.0	70	87	243	260	233	261	0.76

Coding Sequence: ATGCTGAAGACAAACTTTTCCATAAGCGCGATCCTCGGCGAAGCGAACCTCTCGCCGCAGAAGACCGATTTCGATCCAGCATGGAGCAATTCCCTGTCGAGCACGCCGCCCTCGTCCGGCAGCGCGTCTCCCTCCTCGGCCAACACCTCGTCGTGTCCATCGCCTGGCAGCTCGTCGCCGTCCTCCGCCGACAGCAGCTACTCCGAGAGCTCGTCCAAGCCGCCCTACACCTACGGGGCCCTGATCGTGATGGCGCTGCGCAGCTGCCCGGAGAAGCAGCTGACGCTCAGCGGCATCTGCGACTGGATCGCCGACCACTTCCCGTACTACCAGAAGAACCGCAGCAGCTGGCAGAACTCCATCCGGCACAACTTGAGTGTCAGCACCTGCTTCATGCGGCTGCCGCGCGCCCTGGACGACCCCGGGCGCGGCTCCTACTGGGCCATGGCGCCCTACGCCGACGACCTGACCATCGGCGAGACGACCGGCCGCCTGCGCCGCAACAAGAGCCTCCTGTCCGGCGCTGGGGCGTTCGTTCCGAGCCACTCGCAGCACAAGGTCCATCATCCGTACCTCCAACGCGGCCGCCACTGCACGCCGCACGCCGTCTACTTCCCCACGCCGGAGGAGCTGCAGAGGGCGCTGCAGGCCGAGCAGGAGCAGAGGGCGCTGTTCTACCAACACCAGCAGCTGCTGCAGTTCCACAACGACTACTTGCAGCAGTGCAGCGGCGGTCCGGGGTGTTTGTGGACCATAAAGACTCCAGAGGAGTACAATTTCAGGTGCGGGTCGCGTAGAAGTCGCTCGATTCTCATTTCGAATCTCATCCATTCACGCGACCGCAATGATTATTATTCTCTCCGTCGATGGGGAGGCGGAGAAGTGATCGAGACTCTGCCGAAGTCGTTCGTGAGCGACTGA
Protein Sequence: MLKTNFSISAILGEANLSPQKTDFDPAWSNSLSSTPPSSGSASPSSANTSSCPSPGSSSPSSADSSYSESSSKPPYTYGALIVMALRSCPEKQLTLSGICDWIADHFPYYQKNRSSWQNSIRHNLSVSTCFMRLPRALDDPGRGSYWAMAPYADDLTIGETTGRLRRNKSLLSGAGAFVPSHSQHKVHHPYLQRGRHCTPHAVYFPTPEELQRALQAEQEQRALFYQHQQLLQFHNDYLQQCSGGPGCLWTIKTPEEYNFRCGSRRSRSILISNLIHSRDRNDYYSLRRWGGGEVIETLPKSFVSD

Sequence clustering based on sequence similarity using MMseqs2