Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.16 7.7e+02 0.5 0.1 29 38 44 53 15 56 0.74

2 3 2e-12 1e-08 35.4 0.1 4 57 85 133 82 138 0.89

3 3 4.4e-07 0.0022 18.3 0.0 37 74 140 175 132 178 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.16	7.7e+02	0.5	0.1	29	38	44	53	15	56	0.74
2	3	2e-12	1e-08	35.4	0.1	4	57	85	133	82	138	0.89
3	3	4.4e-07	0.0022	18.3	0.0	37	74	140	175	132	178	0.88

Coding Sequence: atggtagacgGGTTGATAGACTACACACCCATACAAGAGATCCGTCAGCAGCGTGCTGTGGCCAAGAAGTCCACGGCGATAAACCCTCCGAGCGCGCCCACCCAGCAGCCTCCGCCCAGCACCGACTCGGTGACCAGCAGAGTGGTGtacTACACGCCCAAGAACGCCGTGAAGCCGTACAAAATGGTCCCTCACACTTGCAGTCTTAAATGCAAGCGGAGCGATGTGCTCTCGCTGAAGGAGCTGCGGACTTACAATCCCCTGGCCAAGCCACTGCTCAGTGGATGGGAACGACAAATAGTCCGGTCCAAAGGGCTTAAGAAGGTGATGTACCGCGCGCCATGTGGGCGACGCCTGCGCGACCTTCGCGAATTGCATCGCTACCTGCGCATCACCCAGAGCGAGCTNNNNNNNNNNGCGCCATGTGGGCGACGCCTGCGCGACCTTCGCGAATTGCATCGCTACCTGCGCATCACCCAGAGCGAGCTGCCAGTCGACCTATTCGACTTTTACCACGGCACGCATTGCCTCGCCGAATTTGTGCTCAACAAGTGTCGCGTCGGTAAAAAGGACCTGTCTCACGGCAAGGAGAACGTGCCGGTCCCGTGCGTCAACTATTACGNN
Protein Sequence: MVDGLIDYTPIQEIRQQRAVAKKSTAINPPSAPTQQPPPSTDSVTSRVVYYTPKNAVKPYKMVPHTCSLKCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRSKGLKKVMYRAPCGRRLRDLRELHRYLRITQSELXXXAPCGRRLRDLRELHRYLRITQSELPVDLFDFYHGTHCLAEFVLNKCRVGKKDLSHGKENVPVPCVNYYX

Sequence clustering based on sequence similarity using MMseqs2