Basic Information

Gene Symbol
-
Assembly
GCA_948465475.1
Location
OX419202.1:9834929-9845059[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 8.1e-05 0.0056 17.4 0.3 3 23 353 373 351 373 0.98
2 17 5.6 3.8e+02 2.2 1.0 2 23 377 398 376 398 0.94
3 17 0.018 1.3 10.0 5.1 1 23 403 426 403 426 0.96
4 17 0.18 13 6.9 0.6 2 23 485 507 484 507 0.92
5 17 0.0012 0.085 13.7 2.2 1 23 513 536 513 536 0.97
6 17 0.029 2 9.4 0.2 2 21 541 560 540 561 0.94
7 17 3.1e-05 0.0022 18.7 0.6 1 23 569 592 569 592 0.96
8 17 1.1 75 4.4 1.0 1 23 597 620 597 620 0.85
9 17 0.0044 0.3 12.0 0.2 5 23 636 654 633 654 0.92
10 17 0.0032 0.22 12.4 1.2 1 23 660 682 660 682 0.98
11 17 0.25 17 6.4 1.9 2 23 688 708 688 708 0.96
12 17 0.00036 0.025 15.4 1.0 2 23 714 735 714 735 0.97
13 17 0.17 12 6.9 0.2 3 23 741 760 740 760 0.96
14 17 3.2e-05 0.0022 18.7 3.1 1 23 807 829 807 829 0.98
15 17 0.00089 0.061 14.1 0.9 2 23 835 856 834 856 0.96
16 17 0.058 4 8.4 0.8 1 23 862 885 862 885 0.93
17 17 0.047 3.2 8.7 1.1 3 23 892 913 891 913 0.95

Sequence Information

Coding Sequence
ATGTCGGACAAGATTTGCTGTGTACGTGGCTGTTTAGTCCGACTTGGAGAAGGTGTGGCACTCCACCGTTTTCCAAATCCTGTGATAGAGAAAGAACGTTTCCAATCCTGGGTTCTAAAATCTGGAGGAGATACCGCTAATTTAGAAGATACATATATCTTTAATAACAGAAGACTTTGCCATAAACATTTTGAGGCAAAGTATCACTGTTCAAAAGGAAGACTCTTTAAGTCTGCTGTACCATCACTATTTTTAACAGGTGTTTCGGCGTATGTACCATCGCCAATTGAGAACCCGATTGCACCTTCACTTGACTTACCTACAACATCTTTTCAAAGACGTCAAGGTGTTTCGGCGTATGTACCAACATCATCGCCAATTGAGAACCCGATTGCACCTTCACTTGACTTACCTACAACATCTTTTCAAAGAAGTCAAGGTCATAAAAGCAACAATATGGACAGTTTTAAACTGAAACTCAAGAATGTCCTCCACGGCACACAATATTGTGGAATATGTTTGGAAAACGAAGATAATATGAGCACCGTTGATAAGTACTTGGAGATTATTGTGAACCAACAGACTCGTAGCGAACCTTTAAGAGTTATTATAGATGTGGTATTACAAGAGACTGAAAACATATTAGCAAGTTCACTCATATGCAACAGCTGTACAGAGAAACTTATCCAGTCATATATTTTTATAGAAAATGCTAAGGAAACATATAAAACTATAGATAACTACATAAATGACTTGTTTAGTAAATCCGATGATATTTGCAAGCATTTGCCTGAGACACACACAGAAAGCACTAATGTAGTTATTGTTTTAGAAAATAATTTCCTAAAATTTCCCGAAAAACAGGAGAGAAAAGATATTTTAAAAGACAAGCATAATGAAGTAGTGGACATGAAGAATGAAATCATAGAAGTGAAAAAAGAAATTGCACCAAAGATAAAGCATTCAAAATTCAAATGTGTGAAATGTTTTTCAATACTACCCTCTTATAGAGCATTAAAATTACACAAAATTCAATGTGAGAAGCAGATTTTTGGATGTGAAATATGTTTTAAAATATTTAGAAATCCACAGTATTTAAATGCACATTACAAAGTGCATTCGAGAGTAAAATGCAAGTTTTGCCAAGAAATTCTGCATGAAAATGAATTACTGGACCATCTTAAAATATACCATGAAGACAGATCACATAAGTGCTATAAATGCAAAGAAGTTTTTTATACCTTAAATGCTTTACAAACTCATGAAAAAATCTGCCATTCATTGAAAGAAGAAATTCCACAATGCATGATGTGCCTAAAGAATTTTACTGAAGAAGAATTGAGATTCCACACCTGCAAATACAATTGCCCGGAATGTTCTGAAATACCGTGCATGCATTATAAATACTTGATGTTTTATAGAGAACAAATTTTAAACCATGCAGTCAAAGTGAAATGTCTGGACTGCGACTATGTTTGTAGAAGAAAGGAGATCCTACTCGGACATGTGAATCGGGAACATTTAAACCACCATCCATTTACTTGTGATAAATGTGGACAACAGTTTTATTCTAAAATTGTTCTAACGGCCCATATTCATAGGTTTCATGAAGACTCTTCTGTGTGCCAGTACTGTGATTCAGAGTTCAGTAATATAAATACATACGAGAGTCATATGAAATCCTGTGAGGATGTCAAAAGGAGATTTGCATGTGACGATTGTCCAGCTTCTTTCAATTCTTCAGATAGTTTGACAAATCATAAAAAACGTCGACACAGCAGAGATATTTTTCCATGTGGCCTTTGCAACAAAAAGTTCCTAAAAGATTCGAAAAGGAAAGAGCATATGGTCAAAGTTCATAGTGGCCTCCAAATTAAGAATAAAGTGATAAATGTAGAGTGTATAGTTTGTCAAGAAAAGTTTGACACTAAAGGAGAGTTGGTACAGCATATGAAATTACATGGTCCTAATGCTTCATATCCCTGCAGGATATGCAACACGGAGTACGAGACTTTGAGACAGTTTAGGGCCCACAATCGCAAACACAACGGACCATTCGCCACTTGCCACGTTTGCGGCAAAGAAATGAGAGAGATCCTGCTAAAAAAACATTTAACTACCCACACAAATTCAGTAGAAACATGTGAAACCTGTGGCAGGTCATTTCAAAATATTACTTTATTAAAATACCATCAAAAAGTTCACTTGGACAGTGTTGCGTGTCCTAAATGTAAGAAAATGATCAACCCAGCGCGACTACGGCGGCATTGGAAAGCGCATTTGATTGAAGAGAATCCTGCCATAAAAGGAATGAAAAAACAGCAGCCAAACTTGAAATGTGAACAGTGCGAATACAAGACTTGGAACAACACACTATTAGAATGCCACATGAACCGCCACCATTTAAAAATAAAACCTTACGTGTGCCATATATGCAGCAAAGACTTTATAGGAAAACATTTGCTGAAAAAACACATAGAAACTCATGACATCAAGAGTGTTGTTTGCATGGTTTGTTTGAAGAGTTTCGCTAACTCTGCCTGCTTGAAAATGCACTTACGTCTACATACCGGTGAAAAACCTTTTACTTGTGAAATATGTGGGGATAGATTCCGATCTTCAAGCATTATGAACGTACATAAGTTAAAAAAGCATTCGGACAAAAGTAATATCTGTCCGCTATGCTCAAATAAGTTTCATACTGTAAGAGATTTGAGGAGACATGTCATCAAAGTACATTGGAAACAGAAAAATAAGCGGTTTGATCCTCGAGAGCTGAAAGGGTTAGATAAAGAGCATTATCATTTGTTTCATGATGGTAGGAGAGTCAAAGTTGCAGAGGCAGATGTTGATTTTTATATGCCTTGTTGA
Protein Sequence
MSDKICCVRGCLVRLGEGVALHRFPNPVIEKERFQSWVLKSGGDTANLEDTYIFNNRRLCHKHFEAKYHCSKGRLFKSAVPSLFLTGVSAYVPSPIENPIAPSLDLPTTSFQRRQGVSAYVPTSSPIENPIAPSLDLPTTSFQRSQGHKSNNMDSFKLKLKNVLHGTQYCGICLENEDNMSTVDKYLEIIVNQQTRSEPLRVIIDVVLQETENILASSLICNSCTEKLIQSYIFIENAKETYKTIDNYINDLFSKSDDICKHLPETHTESTNVVIVLENNFLKFPEKQERKDILKDKHNEVVDMKNEIIEVKKEIAPKIKHSKFKCVKCFSILPSYRALKLHKIQCEKQIFGCEICFKIFRNPQYLNAHYKVHSRVKCKFCQEILHENELLDHLKIYHEDRSHKCYKCKEVFYTLNALQTHEKICHSLKEEIPQCMMCLKNFTEEELRFHTCKYNCPECSEIPCMHYKYLMFYREQILNHAVKVKCLDCDYVCRRKEILLGHVNREHLNHHPFTCDKCGQQFYSKIVLTAHIHRFHEDSSVCQYCDSEFSNINTYESHMKSCEDVKRRFACDDCPASFNSSDSLTNHKKRRHSRDIFPCGLCNKKFLKDSKRKEHMVKVHSGLQIKNKVINVECIVCQEKFDTKGELVQHMKLHGPNASYPCRICNTEYETLRQFRAHNRKHNGPFATCHVCGKEMREILLKKHLTTHTNSVETCETCGRSFQNITLLKYHQKVHLDSVACPKCKKMINPARLRRHWKAHLIEENPAIKGMKKQQPNLKCEQCEYKTWNNTLLECHMNRHHLKIKPYVCHICSKDFIGKHLLKKHIETHDIKSVVCMVCLKSFANSACLKMHLRLHTGEKPFTCEICGDRFRSSSIMNVHKLKKHSDKSNICPLCSNKFHTVRDLRRHVIKVHWKQKNKRFDPRELKGLDKEHYHLFHDGRRVKVAEADVDFYMPC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00072277;
90% Identity
-
80% Identity
-