Tmat008033.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Thalpophila matura
Gene Symbol
egg
Assembly
GCA_948465475.1
Location
OX419205.1:5563616-5612728[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.9 8.4e+03 -3.2 0.1 28 38 1926 1936 1898 1937 0.68
2 2 3.4e-13 9.6e-10 38.3 0.0 4 75 1968 2032 1965 2034 0.89

Sequence Information

Coding Sequence
ATGAGTGCTACAGAAGATAAAAATAGAGAAGAAGACAATACGCTGCGAGAGGGAGGTAGCCAAAACACAGATATTATATCTAAAGGTAATGTACTATCTTTAGAATCTAATAAAAATGCTGAGCCTTTTGGCGTCATGTCTGAAGATACGCCGCACCCAACATTAAAAGTTGCTCTAGAAGGTACTAATGCTAACAAGGACTCTGAAGATGCTACGGTAGATAATTCTAATGAAAATTTAATAAAAACCGATAAAAAGCAGTCTGAATTACCAGAATTAAACACCAATTCAGGCAAAGGTAGTGGTGATAACGCAGCCAAAACTAAGGCTAGTGATGAAACTGATATAGTTGATGATGTCAATATTGAATTAAAAGATACAATGACTTATAATACTGAAGCTATTGCCGAGAAAGATGAAAGTCTTGATAGTTTCCTTGATAAATGTGATGAAATTGAACTTAAGAAAGCCGATGATGCAGATCCAGTTGATGTCGAAGATGATGATATGGAACTAAGATGGGATGATGATGATAGTAGCAATCAAGTTGTGGGAAGTGATAATGGGAGTTCTGATCCTAAAAATGATATTCTCTCAGAAGATCAGCTTTTAGAAGAACCTTCAGATGTCATGAGTAAAGAAACTTCTGATGGAAACCTTGAAGGTACTAATATCAATCTTGATACTGACATTTTAAAAGATGACAGTGAAGGTAATATTATTGATAAAGTCAAACATCCCAAAGAAATAGAAACCACAAATGAATCGGTAGCTTGTCCAAAGCTGGACATTCCTATAGATAATACTGAAAGTAATAGCAAAGACTTACTTTCTAAAGTAACTGAAATAACAAAAGAATCAGAAATATCTTCAAAACTTGATGTTTCTGTAGAAAAGAGTGAAGATAAAAATATCACGGAAGATGAACTTTTAGGAGAACCTGACATAAACACTGAAGGAGTAATAATTTGTCCAGAAATAGAGACTCCTACAGAGACAAACATGGATGAAGATGATGACAATGTTTCAGAAGATAAACTGTTAGAAGAACCTGAAATAAGTAAGGAAGCCTCAGATCTAGATCTAGAAAATGAAATTCTTGTAGAGAAATGTAATGATAAAAATAATGATGAACCATTGAAAGATTTAGAATCTTCCGAACTTATTCTTCAAAAGGAGGTTTCTACAGAAAAAGAAAATCTAGATGATATCATTGAAGAAGATAAGCTTTTGGCAGAATCTGAAAATAATACTGAAACAGCAACATTTAAGATGGCATCTTTTACGGATGTCATCTTAAACACAGACCCTGATGATATAATGTTGGAAGAAACTGACCCTAATGTTGAAAGTTCTGGAATAGAAGAAACAGGGGTCTCAAAGAATAAAGACTCAGATGACAATGATGATGTTCTTTTAGAAGATAAGCTTTTAGAAGAAACTGACCCTGATGTTGAAATTTCTGGAATAGACGAAACAGAAGCATCAAAGAATAAAGATTCAGATGAGAATGATGATGTTCTAGAAGATAAACTTTTAGAAGAAACTGAGACAGCTGTAGTTATTCCTGAAACAGATATTTCTATGGATGTAGATGAGGATAAAGAAGGAGAATTACTAAAAGATGATAAACCTCAACTTGAAAGCGGTACTCCTATGGATGTAGACAATGCTGAACAATCTGTTGAAGATAAGACTAAAGTAGAAGTCAAGAATATAGATCAACCAATGAATATTCAATCTGAAATCGAAAATAAAGTTGTAGACGACCCAATGGACCACCAACTTAATATAGAAAAAACAAATACAGAGCAAATAATAGATGAACATACGAAAGAAAATAATGAAAGTGGTCTATCTGTTGATGATCAATCCGAAATAACTAAGAAAATTACAGATAAACCAATTGAAGATCCAGCTAAAACAGTAGAGAATATTAAAAATGATAATACCATTGATCAAACAAAACTTGAAGATCAGCCAATTGATCAACCAGCTGAAACAGAAACAAATAAAAATAAACCCATTGATGATCAAACTGAAATTAAAGAAAAAAACATAAATCAAGTTATTTCTGAAAAAGAAAATTTAAATGAACCGATTACTAACCAAGCAATAACAGACAACAAGAATGAAGATCAATTAATAGACAATAGTAGTATAATAGAAGAGCTTAATCATAGTCCATTACAAATTGACACACTGACTGATTCTAATATACCTAATGAGCAAACTGAAAAACCAGAAATAACTCTCCCAGAAAATACTACACTTGAAACGAAAGTAGAAAATAAATTAGAATCTGAAAAACCTGAAAAATTCACTAAAAACGAAAACCAGGATACTAATTTAGATAAAAACAATGAGACTGATGAAATTCCACCTAAAAATTCATCATTATATCTAGAAGATTCGTTTGTACACATAAAAACTGATCATGGCTTACACAAACCGGATGTAATGCTAGAAATACCCACACAAGAGTTAATAGACATGGATGATACAGATTTTTCTATGAATCTAGATCAATCTGATGATATTGATAGTACAAATGATTTCGATAAATACGACGATAAAGATGATAAAACAGTCGATAAAATTGCCTCTGTAGAAGATACAGTAAATGAACAAACTATAGTTACTGAACCTACAGTTGATGAAGTTCAAAAAGATAGTGATGTGCTTACAACAGATAAGAAATGTCTAGTTACTGTTCAAGAAATGATTGAAGAAAGTTTAGAGAAAATGTTTGCGGATGAACAACTGGCTAAAGTTACAGAAGTTGTTGGAGCAACAACAAGCCAAATTCAAGAACCGGATGCTCAGCCATCAACATCAGTCACAAGAATGACGCCGGACACGTCAGACGAAGTGCCCGAGATATCAGACAGTCTCGGACTGTTGGCGGAGTCTGCGGGACGGATGATGGAGGATGATGAAGAGCCGGACGATGATGACGACGGTGACGATGACGATGATTTCGATCAGGATGAGAGCAGTAACCAGATCTCTGCAGAGCAATCAGAAGACTCCAACCCTCCCGTGCTAGAGGATATTGAGCCAGTAACGGAACCAGAAGAGAAAGATATCGAGACTCCAGACCCCAAAGAAGATGAGTTCGAATTCGGGATATGTTCTGCTGGCAATACTTCGCAAGATAAGGAGGACAAAATGGATATTGAGGAGTTTGGGACAGTGGAGTTACAAGCGGAAACAGTACGTGATGAGGAGACAACGTCAGCAGAAGATGCGTTGTTGAACGATGGCGACACCAATAAACAAGCTGAGGATGCTCAAGAAACCACAGAGCAGATGGACATTGAAACTGTCAAACTGTCAGACACGTCCGACAACGAGGTGGAGGTTGAGCCAACTAACATTGAGCAGTCTGTGGCAGAACAGAGCAAGGAGATTGAAGaaCAACAAGACAAACCCAAACAATCACCGTCTAAATCGCCAAAGTCAAGCAATCAATCGTCAATCAAGCTATTAACGCAATCCCCGTGTAAGCAATCACCGAGCAAGATGAAGAAATTAGAGATCACCGCACAAGAAGCAAGTTCAGTCGTCAATTATGTGGATTTGGAAGAGAGCAGCTCTTCGGAAGATGACATACAAGAAATACAAAAAGAAACGGAACCGGATACACCCATAGAGAAACCAGCAACTCCTGACCCGGAAAACGTTACCAACGTCAACATACCAACGGGCATAGAGATCATGTGTTCCGGCGGAAGTACGTCAGAGATTGTCACGAAAGAGGGGGAGGTCGTTATTAGTGGGGTGCCGAAGCCGCCGCCGCATAAACCTGCCAGACTGAATACCAGTGAAGTGTCAATAAAAACAGCCAGTAACGCCGAACCTCTAGTTATACCTGAAACTACGATAAATGAACAGCCAACAACACAGTCTAAGCCTAAACTGAGTCAAGAAATATTCAGTCTAGATTCTGACGACGAGGATGGTGCGGCTAAAGAAAAACCGGACTCCCCCCACAAAATGACAGCTCTAGAGCTCGAGAAGGCTCGAGAAACGAGCAAATGTATCAACTATAGTTGCACGAGCGACAACAAGGTGCCTTACAAGATGGCGGACGCGTCGGTTGTAGCGTATTACGACGCGGGCAGGAAGAGGCGCTCTATGGTGTGCCAGCCCTGCGCCGATGTGGTCGCTAATAGGACCAAGAACCTAATCCAAGGCATCAAGGACCTAAAACCACTGCTGGACTTGGAGATGAGCAAACTATCCCAGGACCTGGTGGAGATATCCGACTCGGAGTCTGAAGACGAGGACATGACTCCTGAGGAGCCTAAGGAGAGTATCGGAGAGAAAGGAGCGAAATTCGTAGAAGACAATCTAGCCAAGTTTCTAAACGATACGTGGAAGAAATATGATATGGACACACGATTAAAAGAGACACAGATTATGTTAGACGATGAGATCGAAAAACTTGAACGGGACAGCAAAGAAATCGACGCGATGTTAAACGAATGTCAAGTGGCGACTGACAAACTACGCTGTGAGCTGTACGCGACGTTCGAGTGCCGGCGACAAGAACTGCCTGCACTCGTTGTATGGGACACGCCTGAGACTAAGCTTATTGCACTAGAAGCGGACAGTAACCCTCCCGCTGCCACTGCTGTCGAGGCTGCCGAATCTCGCCAAGCCAAGCGTCGTATGTCTTCATGCAGTGAAACCCCGGCCAAACGACCCGCCATACCGCTTGGGTACGCACCTTTGGATGCCGACTCATCTAAGGAGAACAAAGCAGCTATACCCTTGCCAGATGTGAAAGTTGCAGATGATGACAAAGACATATCAGTGGTCAAGTTATCAGCGGAGGCTGCCCCGGCGGACCTCCCCCCTCCCGGCGAGATATCCCGCCCCCCCCTGCGGGTCAGCATGCCGGTCTACGCCATGAAGAATGCCTTCGGACCCTGGCTTAAAGGCAAGGTGCTGGAGATACAGCCGAAGAATCCTGGAGCGGGCTCCCCATTCTCGCTGTGTCGTGTGAAATTCGACCACAAAATGAAAACCAATGGGAAAATATTGCCGGCGAGGTGTATAGCGTATTCGGAACCGGCTGACGTCAGAATGACTATTGGTACTCGTCTCATAGCTCTATTCAAGGACTCGAACAAACGCGAGTCCTATTACTCGGGTGTTGTCGCTGAAATACCCAATCCAGTCAATAATTATAGGTACCTAGTATTCTTCGACGACGGCTACGCCCAGTACGTTCAGCATCAGTTCACGCGGCTCGTCTGCGAGAGCTCCCACTTAGTTTGGGAGGAAGTGCACCCCTTCTCCCGGGAGTTCGTCCGGGAGTACCTGCTGGCGTACCCTGAGAGACCCATGGTCAGGCTGCATGAAGGACAGCATCTGAAGACCGAGTGGAACGGAAAATGGTGGTCATCTCGAGTGACCAAGGTAGACGCGTCTCTCGCACAAGTGATGTTCGTGGGCGACGGGCGACGGGAGTGGATCTACCGCGGTTCCACCCGATTAGCTCCGTTGTACCTCGAGCTACGGGCTGCCGAGCGACACCGCCCGAGACCTATGCCGAGAAGCAAGGCTCAGCCTAGGTTCAACATGCCTTACGTGGAGTACACTCGGTCGGATGAGCCGGAATCCACCAAGCAGCCTGAAGCTCAAACCGACCAACAACAGCAACAAAACGATGAAATCCGTCGGCAACGCTCCGTGGCTAAGAAGTCGACGTCAATTCCTCAACTTCCCCCCCCTCCACAGCCCTCGATGCCTAACAACGTGGATGCTGTCACCAGCAGAGTTGTGTATTACACGCCTAAGAATGCAGTGCGGCCTTATAAGATGACCCCACACAAATGCAGTCCGAAATGCAAGCGAAGTGACGTGCTATCACTAAAGGAGTTGAGGACTTACAACCCGTTGGCCAAACCGCTGCTCAGCGGGTGGGAGAGACAAATAGTCCGGTACAAGGGCCACAAGGAGGTGATGTACCGCGCGCCGTGCGGGCGGCGCGTGCGCGGCATGCGCGAGCTGCACCGCTACCTGCGCGCGGTGGACTCCGACCTGCCCGTCGACCTGTTCGACTTCCACCACGCCACGCACTGCCTCGCCGAGTTCGTACTCAACAAGTGCCTCGTCGGGAAGAAGGATCTCTCGCACGGCAAAGAGAACGTCCCAGTTCCGTGCGTGAACTACTACGACGACTCGCTGCCGGAATTCTGTTCCTACAACACTGAGCGCACGCCCACGGCCGGGGTACCGCTTAACTTGGAGCCCGAGTTCCTGTGCGGCTGTGATTGCACTGACGATTGTCAGGATAAGTCTAAATGCGCTTGCTGGAAGATGACGCTAGAGGGCGCTCGCACCATTGGTCTGGATGGTCCAAACGTGGGCTACGTGTACAAGCGGTTGCCCGAACCATTGCCTTCTGGCATATACGAGTGTAATTCTAGGTGTAAATGCAAGCACACATGCTTGAATCGCGTGGCGCAGCATCCTCTTCAATTAAAGTTACAGGTTTTCAAAACTCTGAACCGCGGTTGGGGTATCAGGGCACTCAACGATGTGCCTAAAGGTTCGTTCCTGTGCGTGTACGCTGGTAATCTACTCACAGACGCCACTGCTAACCTGGACGGTTTGAACGAAGGGGACGAATATCTAGCAGAATTGGACTATATAGAGGTAGTAGAACAAATGAAAGAGGGCTACGAAGAGGACATTCCAGACGCCGATAAGAAATTAGACAAGAAAGAACAAGCAAAAGACGATGAAACTGAAGAGGATGAGTCTTCTACATCGGAGGAGGAGGACAGGGCCTCCAAGAACGACAAGGAAGACGATGACTTCAGGCCCGGGTACATCGGCCTAGGTGTCACGGAGTTCAAcaaACGTCTTCGTAAACGCGAGAGAGCTAAAAAAGATAAAGGGAACACAGCGACCGTCGACAAAGATAAAGAAAAAGATGGCAAAGATAACAAAGACCCGAACGCCGAAGAGGATTGCATTACAATCAGCGATGACGAAGAAGTAAGAGAACCTTCGAGATTCATGGTGCAAGCCGGCATGGGAGCTAACGAGTTTATATCAAAATACAAATCTGTTCGCACGCTATTCGGTAAGGACGAGGCGTGCTATATCATGGACGCTAAGGTTCAAGGCAACATTGGCAGATATCTCAACCATTCCTGCACCCCAAACGTTTTTGTCCAAAACGTGTTTGTAGACACGCACGACCCTCGGTTCCCTTGGGTGGCGTTCTTCGCACTATCACACATTAAAGCAGGCACAGAACTCACCTGGAACTACAACTATGACGTAGGTTCGGTTCCCGGGAAGGTACTATACTGTTTCTGTGGAGCGCCCAACTGTAGGGGACGGTTGTTGTAA
Protein Sequence
MSATEDKNREEDNTLREGGSQNTDIISKGNVLSLESNKNAEPFGVMSEDTPHPTLKVALEGTNANKDSEDATVDNSNENLIKTDKKQSELPELNTNSGKGSGDNAAKTKASDETDIVDDVNIELKDTMTYNTEAIAEKDESLDSFLDKCDEIELKKADDADPVDVEDDDMELRWDDDDSSNQVVGSDNGSSDPKNDILSEDQLLEEPSDVMSKETSDGNLEGTNINLDTDILKDDSEGNIIDKVKHPKEIETTNESVACPKLDIPIDNTESNSKDLLSKVTEITKESEISSKLDVSVEKSEDKNITEDELLGEPDINTEGVIICPEIETPTETNMDEDDDNVSEDKLLEEPEISKEASDLDLENEILVEKCNDKNNDEPLKDLESSELILQKEVSTEKENLDDIIEEDKLLAESENNTETATFKMASFTDVILNTDPDDIMLEETDPNVESSGIEETGVSKNKDSDDNDDVLLEDKLLEETDPDVEISGIDETEASKNKDSDENDDVLEDKLLEETETAVVIPETDISMDVDEDKEGELLKDDKPQLESGTPMDVDNAEQSVEDKTKVEVKNIDQPMNIQSEIENKVVDDPMDHQLNIEKTNTEQIIDEHTKENNESGLSVDDQSEITKKITDKPIEDPAKTVENIKNDNTIDQTKLEDQPIDQPAETETNKNKPIDDQTEIKEKNINQVISEKENLNEPITNQAITDNKNEDQLIDNSSIIEELNHSPLQIDTLTDSNIPNEQTEKPEITLPENTTLETKVENKLESEKPEKFTKNENQDTNLDKNNETDEIPPKNSSLYLEDSFVHIKTDHGLHKPDVMLEIPTQELIDMDDTDFSMNLDQSDDIDSTNDFDKYDDKDDKTVDKIASVEDTVNEQTIVTEPTVDEVQKDSDVLTTDKKCLVTVQEMIEESLEKMFADEQLAKVTEVVGATTSQIQEPDAQPSTSVTRMTPDTSDEVPEISDSLGLLAESAGRMMEDDEEPDDDDDGDDDDDFDQDESSNQISAEQSEDSNPPVLEDIEPVTEPEEKDIETPDPKEDEFEFGICSAGNTSQDKEDKMDIEEFGTVELQAETVRDEETTSAEDALLNDGDTNKQAEDAQETTEQMDIETVKLSDTSDNEVEVEPTNIEQSVAEQSKEIEEQQDKPKQSPSKSPKSSNQSSIKLLTQSPCKQSPSKMKKLEITAQEASSVVNYVDLEESSSSEDDIQEIQKETEPDTPIEKPATPDPENVTNVNIPTGIEIMCSGGSTSEIVTKEGEVVISGVPKPPPHKPARLNTSEVSIKTASNAEPLVIPETTINEQPTTQSKPKLSQEIFSLDSDDEDGAAKEKPDSPHKMTALELEKARETSKCINYSCTSDNKVPYKMADASVVAYYDAGRKRRSMVCQPCADVVANRTKNLIQGIKDLKPLLDLEMSKLSQDLVEISDSESEDEDMTPEEPKESIGEKGAKFVEDNLAKFLNDTWKKYDMDTRLKETQIMLDDEIEKLERDSKEIDAMLNECQVATDKLRCELYATFECRRQELPALVVWDTPETKLIALEADSNPPAATAVEAAESRQAKRRMSSCSETPAKRPAIPLGYAPLDADSSKENKAAIPLPDVKVADDDKDISVVKLSAEAAPADLPPPGEISRPPLRVSMPVYAMKNAFGPWLKGKVLEIQPKNPGAGSPFSLCRVKFDHKMKTNGKILPARCIAYSEPADVRMTIGTRLIALFKDSNKRESYYSGVVAEIPNPVNNYRYLVFFDDGYAQYVQHQFTRLVCESSHLVWEEVHPFSREFVREYLLAYPERPMVRLHEGQHLKTEWNGKWWSSRVTKVDASLAQVMFVGDGRREWIYRGSTRLAPLYLELRAAERHRPRPMPRSKAQPRFNMPYVEYTRSDEPESTKQPEAQTDQQQQQNDEIRRQRSVAKKSTSIPQLPPPPQPSMPNNVDAVTSRVVYYTPKNAVRPYKMTPHKCSPKCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRYKGHKEVMYRAPCGRRVRGMRELHRYLRAVDSDLPVDLFDFHHATHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLDGPNVGYVYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQVFKTLNRGWGIRALNDVPKGSFLCVYAGNLLTDATANLDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPDADKKLDKKEQAKDDETEEDESSTSEEEDRASKNDKEDDDFRPGYIGLGVTEFNKRLRKRERAKKDKGNTATVDKDKEKDGKDNKDPNAEEDCITISDDEEVREPSRFMVQAGMGANEFISKYKSVRTLFGKDEACYIMDAKVQGNIGRYLNHSCTPNVFVQNVFVDTHDPRFPWVAFFALSHIKAGTELTWNYNYDVGSVPGKVLYCFCGAPNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-