Basic Information

Transcription Factor Domain

TF Family: bHLH
Domain: HLH domain
PFAM: PF00010
TF Group: Basic Domians group
Description: A basic helix-loop-helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors.It should not be confused with the helix-turn-helix domain.The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino acid residues that facilitate DNA binding. In general, one helix is smaller, and, due to the flexibility of the loop, allows dimerization by folding and packing against another helix. The larger helix typically contains the DNA-binding regions. bHLH proteins typically bind to a consensus sequence called an E-box, CANNTG. The canonical E-box is CACGTG (palindromic), however some bHLH transcription factors, notably those of the bHLH-PAS family, bind to related non-palindromic sequences, which are similar to the E-box. bHLH TFs may homodimerize or heterodimerize with other bHLH TFs and form a large variety of dimers, each one with specific functions.https://en.wikipedia.org/wiki/Basic_helix-loop-helix
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.1e-13 4.5e-11 42.7 2.3 1 52 163 214 163 215 0.96

2 2 7.1 3e+03 -1.5 0.2 13 27 228 242 220 246 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.1e-13	4.5e-11	42.7	2.3	1	52	163	214	163	215	0.96
2	2	7.1	3e+03	-1.5	0.2	13	27	228	242	220	246	0.73

Coding Sequence: ATGGCGGCAGACGCTGCGGTAGTACGACGGGGTCGACGCCCTCCCCCCCGCCGTACGCCGCCCCCACCCCCTCCCGCGCACCTGACCACTGCAGTCGCATCTCCCCGACTAGATCTAGCCCCCTGCGATCGTATACAGATGTGGCTACGACAATCGACGCCCGCCTTTTATGGTGATGTGAGCGTAATGAACGAGGAGGAAATCGACGTGGTATCTGTAGGCACCCAACAGCCGCTGCCTACGTCGCAAATGCATGTCCGCACGGACTCATTGCCTCGTGTGCCATCAGCCCAGGAGCGGCAGCACATACAGCGGACAGTGGAGACTGCTATCACTCCGCGGTCTCCGCGACCGGCGGCCAGGAAGCGCCTGGTGCCGCCACCCAGCATAGCGGCCGCGTCGCGCCGCCGGGCTCGCGGCCCCGGCCGCCGCGGACGCCGGTCTAACACCGACACTGACTCCGAGGCCGAGTCGCCCGAGATAGAACGCCGCTCAATACACAACGACATGGAGAGACTCCGGCGCATAGGTCTCAAAAATCTCTTCGACGAACTCAAAAAGCAAATCCCGGCCACGAGAGATAAGGAGCGCGCGCCTAAAGTGGTCATACTGAGAGAAGCGGCCTCCCTCTGCAGAAAGCTTAGCCAAGAGGAGCTGGAGAGGGAAAAGCTGAAAAAGAAACAACACCAACTTGTGACGAAGTTGAAAAAGCTGCGTACGATGCTCTCGGCGCGCTACCGCTCGTACTGA
Protein Sequence: MAADAAVVRRGRRPPPRRTPPPPPPAHLTTAVASPRLDLAPCDRIQMWLRQSTPAFYGDVSVMNEEEIDVVSVGTQQPLPTSQMHVRTDSLPRVPSAQERQHIQRTVETAITPRSPRPAARKRLVPPPSIAAASRRRARGPGRRGRRSNTDTDSEAESPEIERRSIHNDMERLRRIGLKNLFDELKKQIPATRDKERAPKVVILREAASLCRKLSQEELEREKLKKKQHQLVTKLKKLRTMLSARYRSY

Sequence clustering based on sequence similarity using MMseqs2