bHLH
- Domain
- HLH domain
- Group
- Basic Domians group
- PFAM
- PF00010
- Desciption
- A basic helix-loop-helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors.It should not be confused with the helix-turn-helix domain.The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino acid residues that facilitate DNA binding. In general, one helix is smaller, and, due to the flexibility of the loop, allows dimerization by folding and packing against another helix. The larger helix typically contains the DNA-binding regions. bHLH proteins typically bind to a consensus sequence called an E-box, CANNTG. The canonical E-box is CACGTG (palindromic), however some bHLH transcription factors, notably those of the bHLH-PAS family, bind to related non-palindromic sequences, which are similar to the E-box. bHLH TFs may homodimerize or heterodimerize with other bHLH TFs and form a large variety of dimers, each one with specific functions.https://en.wikipedia.org/wiki/Basic_helix-loop-helix
- Rederence
-
- Function of the c-Myc oncoprotein. Kato GJ, Dang CV. FASEB J. 6, 3065-72, (1992).
- A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Murre C, McCaw PS, Baltimore D. Cell 56, 777-83, (1989).
- CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis. Krause M, Fire A, Harrison SW, Priess J, Weintraub H. Cell 63, 907-19, (1990).
- The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Riechmann V, van Cruchten I, Sablitzky F. Nucleic Acids Res. 22, 749-55, (1994).
Statistic of Transcription Factors
DNA Logo
Download
Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000002 | Abrostola tripartita | Atri004910.1 | hand2 |
| iTF_00000003 | Abrostola tripartita | Atri003664.1 | ptf1a |
| iTF_00000004 | Abrostola tripartita | Atri001535.1 | Nhlh1 |
| iTF_00000005 | Abrostola tripartita | Atri015511.1 | ase |
| iTF_00000006 | Abrostola tripartita | Atri022165.1 | fer3 |
| iTF_00000007 | Abrostola tripartita | Atri015507.1 | l(1)sc |
| iTF_00000008 | Abrostola tripartita | Atri015509.1 | l(1)sc |
| iTF_00000009 | Abrostola tripartita | Atri017959.1 | ato |
| iTF_00000010 | Abrostola tripartita | Atri015505.1 | l(1)sc |
| iTF_00000011 | Abrostola tripartita | Atri006102.1 | tal1 |
| iTF_00000012 | Abrostola tripartita | Atri005315.1 | TWIST2 |
| iTF_00000013 | Abrostola tripartita | Atri001674.1 | tx |
| iTF_00000014 | Abrostola tripartita | Atri009805.1 | bhlhe22 |
| iTF_00000015 | Abrostola tripartita | Atri021378.1 | TFAP4 |
| iTF_00000016 | Abrostola tripartita | Atri018137.1 | tap |
| iTF_00000017 | Abrostola tripartita | Atri003875.1 | hlh-13 |
| iTF_00000018 | Abrostola tripartita | Atri005178.1 | atoh8 |
| iTF_00000019 | Abrostola tripartita | Atri017092.1 | Msc |
| iTF_00000020 | Abrostola tripartita | Atri022249.1 | NHLH2 |
| iTF_00000021 | Abrostola tripartita | Atri015901.1 | MLX |
| iTF_00000022 | Abrostola tripartita | Atri015308.1 | Srebf1 |
| iTF_00000023 | Abrostola tripartita | Atri012712.1 | TCF15 |
| iTF_00000024 | Abrostola tripartita | Atri012255.1 | Hey |
| iTF_00000025 | Abrostola tripartita | Atri001592.1 | USF1 |
| iTF_00000026 | Abrostola tripartita | Atri021996.1 | MAX |
| iTF_00000027 | Abrostola tripartita | Atri013468.1 | dimm |
| iTF_00000028 | Abrostola tripartita | Atri012873.1 | dpn |
| iTF_00000029 | Abrostola tripartita | Atri003391.1 | cyc |
| iTF_00000030 | Abrostola tripartita | Atri005240.1 | E(spl)mbeta-HLH |
| iTF_00000031 | Abrostola tripartita | Atri012544.1 | hry |
| iTF_00000032 | Abrostola tripartita | Atri002905.1 | Mlxip |
| iTF_00000033 | Abrostola tripartita | Atri005251.1 | E(spl)mbeta-HLH |
| iTF_00000034 | Abrostola tripartita | Atri018184.1 | cwo |
| iTF_00000035 | Abrostola tripartita | Atri011823.1 | tgo |
| iTF_00000036 | Abrostola tripartita | Atri005239.1 | E(spl)mgamma-HLH |
| iTF_00000037 | Abrostola tripartita | Atri008670.1 | Tfeb |
| iTF_00000038 | Abrostola tripartita | Atri001021.1 | da |
| iTF_00000039 | Abrostola tripartita | Atri017191.1 | Myc |
| iTF_00000040 | Abrostola tripartita | Atri007103.1 | SUM-1 |
| iTF_00000041 | Abrostola tripartita | Atri003951.1 | ahr-1 |
| iTF_00000042 | Abrostola tripartita | Atri003871.1 | Clk |
| iTF_00000043 | Abrostola tripartita | Atri017082.1 | emc |
| iTF_00000044 | Abrostola tripartita | Atri014022.1 | AHRR |
| iTF_00000045 | Abrostola tripartita | Atri002932.1 | - |
| iTF_00000046 | Abrostola tripartita | Atri014066.1 | trh |
| iTF_00000047 | Abrostola tripartita | Atri007718.1 | Sim1 |
| iTF_00000048 | Abrostola tripartita | Atri022172.1 | HIF1A |
| iTF_00000049 | Abrostola tripartita | Atri012555.1 | Bmal1 |
| iTF_00000050 | Abrostola tripartita | Atri014108.1 | cky-1 |