Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.15 1e+03 0.5 0.1 7 15 11 19 5 23 0.66

2 3 6.7e-16 4.6e-12 46.5 4.5 6 67 95 156 91 159 0.94

3 3 4 2.7e+04 -4.3 1.3 5 11 305 311 303 312 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.15	1e+03	0.5	0.1	7	15	11	19	5	23	0.66
2	3	6.7e-16	4.6e-12	46.5	4.5	6	67	95	156	91	159	0.94
3	3	4	2.7e+04	-4.3	1.3	5	11	305	311	303	312	0.59

Coding Sequence: ATGATAGAAGAGAAGTCGTATATAGCGACGTGGTGCCCAATATGTGATAAGCAAGTAAGCATCGAAGAACGAGACACTTACAGACTTCTCATACATATTCGTAAAAATCATCCGGAAATCGCTGACAAATGTTTGAACAATCAGAAGAACGGGGGGTTAAGGATATCATCGAATCGGATTTCGTCTCCAGTCACGCCAGTCGATAGTTGTAACAGCAAGAAGAACGAACCGAAGAAAGTTTACGCTACTCGTGTGGACACGTGGAAATTGCACGGCGAGAGGAAAGTCTGCCCCCAATGCCGGAGGGAAGCTGTGCCGACGCTTCATACGCGCGGCGACAAACTAACGACCTCACATATCGGAGCCATCTGCCTTCTCGGATGCTGGCCCTTCTGCTTCATACCGTTGTTGATGAGACGGGACAAAAGAGTGCGCACGTTGTGCCCGCGTTGCGGCTACGAGTACGGGATTTGTACGCGAGAAAAGAGTAAGCTGATCGCCTGTTCGCCCGAATGCGCGTCTAGCTGCGGGAAATTAAGCGATTTCACAAATTCACAATTGTGTCATCTTCGAACAAAGTGCGGCGCATTGCAAATGCAACCGGAACATGGCCAAAAAACACTTTCCATGGGTGACGAGACTGTGAGAGCTCTCAGAGTCTCGGAGGAGCGTCCTCGGCGAGAAGAAGGCAGATCTTGCCGGTCGCAATCGAAGCTATCGCACGGATATGCCTTTTGTGCGAACCAGGTCACGAATTGCGGTTCACCATATGACGAGTACAGCAGCGACGATTGCGTGGACAAAAGATGGGATCGTCGTCGCGACTTGGACGAATCGAAAGCTTCGAAAGCTCGGGAACAAAGTGAATCCGAAGGCAGTGGGGGGACGGCAACGGTCGATTTTTATGCGAGACAGGTTTGCTGTCGGGAATGTGGCTAG
Protein Sequence: MIEEKSYIATWCPICDKQVSIEERDTYRLLIHIRKNHPEIADKCLNNQKNGGLRISSNRISSPVTPVDSCNSKKNEPKKVYATRVDTWKLHGERKVCPQCRREAVPTLHTRGDKLTTSHIGAICLLGCWPFCFIPLLMRRDKRVRTLCPRCGYEYGICTREKSKLIACSPECASSCGKLSDFTNSQLCHLRTKCGALQMQPEHGQKTLSMGDETVRALRVSEERPRREEGRSCRSQSKLSHGYAFCANQVTNCGSPYDEYSSDDCVDKRWDRRRDLDESKASKAREQSESEGSGGTATVDFYARQVCCRECG

Sequence clustering based on sequence similarity using MMseqs2