Basic Information

Gene Symbol
-
Assembly
GCA_010645165.1
Location
WIUW01000596.1:18217-21639[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00024 0.026 15.2 1.5 1 23 106 129 106 129 0.94
2 13 0.0084 0.92 10.3 4.6 2 23 253 275 253 275 0.91
3 13 0.0012 0.13 13.0 4.1 3 23 320 341 319 341 0.96
4 13 4.7 5.2e+02 1.7 7.6 3 23 427 448 426 448 0.95
5 13 0.071 7.8 7.4 1.9 1 23 501 524 501 524 0.94
6 13 0.00038 0.042 14.6 0.2 2 23 572 594 571 594 0.96
7 13 0.00061 0.067 13.9 0.1 3 23 619 640 618 640 0.92
8 13 0.0061 0.68 10.8 3.6 2 23 682 704 681 704 0.96
9 13 0.083 9.1 7.2 4.2 3 23 719 740 717 740 0.92
10 13 0.00021 0.023 15.4 0.1 2 23 785 807 785 807 0.94
11 13 0.039 4.2 8.2 1.6 1 23 888 910 888 910 0.98
12 13 0.00057 0.063 14.0 1.3 2 23 924 946 923 946 0.96
13 13 0.0054 0.6 10.9 0.8 1 23 1022 1045 1022 1045 0.98

Sequence Information

Coding Sequence
ATGTCCTCAACGATGGCGCATGAGGCGACGATATCGGAGTTGACGGAATTGGACAGCGACGGATCGAGTTGCGGTGAACGCGACGCGAGGAAACGTCTCCGTTTCGACGTGGATTCGACCGGGCCGAAGAAGAGGCGAAAACAAACGACGCCCGTGAGATTCTCCTCGACGTTGGTCCCCGGCGTGCACGAGGAATCgaacgaggacgaggacgaggacgaggacgaggacgaggacagCGAAGGTAAGCTGTCGTCGCAATCACCGGTGCCGTGTCAATCGTCGATAAGGGACGAGAATAACCTGAATAACGAGTTCCGTTGCAAATACTGTAGTCAGTTTTTCGACAGCAAAGAAACGCTGAACGTTCACCTCGACAATGAGCACGGCTCCGCGAGTCAGAGTCGAAATAGGTCCCCGAATGTCGCGGTCAAACAAGAATCGTCACAGCAGCTGGACCAATCCGAGAATCCCGTTAATTTGCTTAGCGTGAAGGACTTCGCGATAAATTGGCTAGCCAGCGGGCAACACGTGCAATCGCACAATGCACAAATGCAGACGCAGAACGAGGAACCGTGGATGCCCGGATCAGTTAATCAAATGCCATCGTTACCCAATCACTTGCAAATCCTTTCTGGCTTTCCTAGCGCGTTGGCGCAATATTTACCAGTGCCCGCGTTCCCGTTAACAGATTCCGGTTCCATGGTGAAACCGTCGTTAGGACCAACGCCAGTCAGGATCTTTAATCCGGAAGCGTACTGTGATCTGTGCAATAAAGAATTCTGCAACAAGTATTTCCTCAAGACGCACAAAGCGAACAAGCACGGTATCTACGCCGACTCGCCGGGACCTAGCACCCAGGACAATAGCATTCCAGGGCCATTGTTCCCTACCAACTATTCTAGTAACGTGATTAAGCTGGAACTACCGCCTACGCCGCCTACGCCGACCGTCGCGTGCGATCTCTGTCACAAGCGTTTCAAGAACGAGGATTCGATGCGTAAACACAAGCAGAAGATGCACACCGAGCTGCTGGATCAGTCGCAGGAGTCGCAGTCCATCAATTTGTCGCAAAACGAGGAGGACAGGGACACCCCGAGGGACAGTCTCGGCGGTATGGAGACGTTGTTCAAACAGGAATACGGGATAGAGCAGGAGGACGCAACGTTCGTACCAGCGCCCAGGCATCTATCGCCTCAATCGATTCAGCAGGCTCGGGACTCGGGTTTCAGCGCCGATCGGCTTCGTCGTTTGGGAGTTATAAACCCGGAGGCGTTCTGCGAGATATGCTGCAAAGAGTATTGCAACAAGTACTTCCTGCGAACGCACAAAATGAAGAGGCACGGGATCGTCGTACACGACAACGAGAGATCACCACCGAGCAATCCAGGAGCGGCGCCCAGCTGGCATCAAGTGCAGACCAGCCCGTTGAATCTGATCGTGACGGAGTCGAATTCTGGTAGCACGgagtcgaacgaacgagcagCCGGCGACTCCGATTACGAGTGCAAGTCGTGCGGGATACGTTTCCAGACGATTGGCCTGTATCAAGCTCACTGTCGGAAGATGCACGAGAGCGAGGAGCAGCAGTCGCCCAGGCCAGACTGCGAGTTGGACGCGGCCGATCAACGAAACGATTCGATCTCGGAGGATCTTCAGAAATTGCAGACGATGCTGTTGCAGTTGAACGGGCTTAAGTCTAGCAAGGGGTTATCGTGCAACGTGTGCGGAAAAGAATCCGAGACCAGAGCTGCGTTGCATATTCATATGATAACGGAGCACGGAGCTGCTAGCCAAGAAGATCCAACGTCCTCGCCGCAAGGAAGATCACCCTTAACCACGAACGTCGGGTTCTGCGCCCTCTGCGGCAAAGATTACGCGAGTCAAGACGCACTCAGGAAGCACATCACCGACGAACATCAACAACCACCGATTTCAAATGCCAGCGTTCCTCACGCTCCTACGGCGACTACGACCAATACAAATTCGTCGAGCCAGACTCCGACGGAGAGGAAAGTCACGTCGATGACGCCCACGTCCAGCTACTGCGAGATATGCAACAAGGAGTTGTGCAACAAGTACTTCATGAAGACGCACATGCAAAGAATGCACGGCATTGAGATCGAAAACGGAGCCCAGATCGGAGGCGTGATATGCAACATTTGCAACAAGGAGCTGTGCAGCAAGTACTTTCTGCGCGTTCACAAGCACAACACCCACGGCATAGTCGATGAAAATACTGCCAGTTCGGTGAAACAAGAGGCCCACGAAACAACGAGTGCGGACGATGCTGCTTTGAAGCCGGAACAGCTCGGTGACCTGAGTCACAGATACTTCACTCACTTCACAGAGGTTTGCCCGATCTGTAGCAGAAGGTTCCGTAGTATAAAGTGGTTGAAGGCACACCTGATGGGTGATCATGGGAAAACGGGTGTCGACAAATGGCGCGAAATGGAGCAACAGTATCAAACGATGCCGAAATCGGCGAACAGAGCGGTAAATATGATATCGAAGAACGCTCAACAGAGCTCGAATCTGAAGATACCGAATGGATTTGAAATGTCGCAACACCTCAAGTCCACCGACTACACTGGTTTGGGTAATCAAGTTCTGTCGAATTTACTAGGCTCGTCTACGGAAGCAGATCAGCAGGTGAAAAGCTATCGTTGCTCCTACTGCAATTTCACGACCACCGTGCTGCCATTCCTCTTTCTTCACGAGAGGTCTCACGTAATTTCGCACGACAACATCGAAGGAGAAAAATCGCTGCAATGCCCGATCTGCTCGCAAGGTTTTCATCAGCCGGAGATGCTGCATCAGCATCTGCTCACGTCGCACCAGTTCCCCACTTTGCTGCCCCATTTCCAACCCCCTCTGTTTAACAGTTTAAGCCTGGACGCGGAGAAGTTGAACGAAGCCAAAGAGAAACTCGACGTGGAAGCAAAGGAGGATCGCATCGAGAACAGTTCGCAAGCCATTGCCAGCCAGCAACATATTCCCGATCCGGCGAGAAACAAACGACAGGCGGACGAAACGGCGGTGCAAGTCACGCCTCACGGTGTGTATAAATGCGCGCAATGCGGCTACGCGACGACCAATTTGAACAGGATCAAAAAACACGTGAGGAAAGATCACAGAACGGTCAGCGATCCTACCGACAGCGTGCTCGCCGAGCTCAGCAGAACTTTGAAAGACGTTGCCAACAAGCACAAGGTGCCAGCTTGCTACGCCACGCCGCAGGACATGAATTCGAATCCTGACAAGACGATCATGCAGCCGTTTCTAATCGAGGAACAGGACACGATGCAAGCTGGAGAGGAGTCCAGCTCGGAGAGACGATTCGCGCCGGCTTTGGTCTACTTGCCGGTTAAGTCGCGAATCAACAACGCGTTCACCGCGTCCTTCACCCTCAGTCCTGCTTGA
Protein Sequence
MSSTMAHEATISELTELDSDGSSCGERDARKRLRFDVDSTGPKKRRKQTTPVRFSSTLVPGVHEESNEDEDEDEDEDEDSEGKLSSQSPVPCQSSIRDENNLNNEFRCKYCSQFFDSKETLNVHLDNEHGSASQSRNRSPNVAVKQESSQQLDQSENPVNLLSVKDFAINWLASGQHVQSHNAQMQTQNEEPWMPGSVNQMPSLPNHLQILSGFPSALAQYLPVPAFPLTDSGSMVKPSLGPTPVRIFNPEAYCDLCNKEFCNKYFLKTHKANKHGIYADSPGPSTQDNSIPGPLFPTNYSSNVIKLELPPTPPTPTVACDLCHKRFKNEDSMRKHKQKMHTELLDQSQESQSINLSQNEEDRDTPRDSLGGMETLFKQEYGIEQEDATFVPAPRHLSPQSIQQARDSGFSADRLRRLGVINPEAFCEICCKEYCNKYFLRTHKMKRHGIVVHDNERSPPSNPGAAPSWHQVQTSPLNLIVTESNSGSTESNERAAGDSDYECKSCGIRFQTIGLYQAHCRKMHESEEQQSPRPDCELDAADQRNDSISEDLQKLQTMLLQLNGLKSSKGLSCNVCGKESETRAALHIHMITEHGAASQEDPTSSPQGRSPLTTNVGFCALCGKDYASQDALRKHITDEHQQPPISNASVPHAPTATTTNTNSSSQTPTERKVTSMTPTSSYCEICNKELCNKYFMKTHMQRMHGIEIENGAQIGGVICNICNKELCSKYFLRVHKHNTHGIVDENTASSVKQEAHETTSADDAALKPEQLGDLSHRYFTHFTEVCPICSRRFRSIKWLKAHLMGDHGKTGVDKWREMEQQYQTMPKSANRAVNMISKNAQQSSNLKIPNGFEMSQHLKSTDYTGLGNQVLSNLLGSSTEADQQVKSYRCSYCNFTTTVLPFLFLHERSHVISHDNIEGEKSLQCPICSQGFHQPEMLHQHLLTSHQFPTLLPHFQPPLFNSLSLDAEKLNEAKEKLDVEAKEDRIENSSQAIASQQHIPDPARNKRQADETAVQVTPHGVYKCAQCGYATTNLNRIKKHVRKDHRTVSDPTDSVLAELSRTLKDVANKHKVPACYATPQDMNSNPDKTIMQPFLIEEQDTMQAGEESSSERRFAPALVYLPVKSRINNAFTASFTLSPA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00224784;
90% Identity
iTF_01417927;
80% Identity
-