Tocu016213.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Tethea ocularis
Gene Symbol
PAX6
Assembly
GCA_963555595.1
Location
OY741975.1:4277646-4301727[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.5e-74 1e-70 235.9 0.7 1 125 30 154 30 154 0.99
2 2 2.8 4.5e+03 -2.0 0.0 89 120 239 270 212 276 0.63

Sequence Information

Coding Sequence
ATGCTGCCAGCGCAGCAACTGGCTCCGATCAGCCCCTGGCCGCCGGACGCCAACCTACTAGACCGCATGGACGACCTGGCGCACAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGGGTGTTTGTAGGAGGCAGGCCGCTGCCGGACTCGACGCGGCAGAAGATCGTGGAGCTGGCGCACTCGGGCGCGCGGCCCTGCGACATCAGCAGAATCCTGCAGGTCTCCAACGGCTGCGTCTCCAAGATACTTGGCAGGTACTACGAGACCGGGTCAATTAGACCCCGCGCTATCGGCGGGTCGAAGCCGCGAGTGGCCACGGCGGAGGTGGTCAGTAAGATAGCGCAGTACAAGCGCGAGTGCCCCTCGATCTTCGCTTGGGAGATCAGGGACCGCCTGCTCAGCGAAGGAGTCTGCACTTCGGATAATATTCCTAGTGTATCATCAATAAACCGGGTGCTCCGCAACCTAGCAGCCCAGAAGGAGAAGTCAAGCAGCCAGCAGCCACAAAACGACTGCTCGACGCCGGTGTACGAGCGGCTGCGACTGCTCGGTACACCGGGGTCCGCCTCCGCCTGGCCCCGGGCGCCCTGGCCAGCCCAAATAGACACGAGGACTCCGCCTTACCAGCTGCACAGTCTCAGTCCTGGACCTCAGGCGATTGGTTGCAATGGTGGAGATATGACCGGGATGAAGAAAgTTCTTTTAATCACGTCGATGGAGATTCCAGCTCTGTTTGCTGCGGATGTGGAGGCGTGGCGCGTGCTATGCGCTGTGAATACGGTCACATCCACGCCACTCTCACACAGCATTTGTTTTATCCATCGACTTATAGTTTGA
Protein Sequence
MLPAQQLAPISPWPPDANLLDRMDDLAHKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSVSSINRVLRNLAAQKEKSSSQQPQNDCSTPVYERLRLLGTPGSASAWPRAPWPAQIDTRTPPYQLHSLSPGPQAIGCNGGDMTGMKKVLLITSMEIPALFAADVEAWRVLCAVNTVTSTPLSHSICFIHRLIV