Basic Information

Insect: Tetanocera ferruginea
Gene Symbol: PAX6
Assembly: GCA_958299015.1
Location: OY282644.1:38033266-38060721[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 9.7e-36 1e-32 114.0 0.0 8 125 11 128 4 128 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	9.7e-36	1e-32	114.0	0.0	8	125	11	128	4	128	0.89

Sequence Information

Coding Sequence: ATGGCATCTAGTgttgcaacagcaacagcttCAGGCAATGTATTTACCGGTGGCCCACCGTCACCCACCACACTGAGTAACCTGGTCTCGCAACATCGTTTGCTGGAATTATCGCGATTTGGTTTACGCGGCTATGATTTGGCTCAACACATGTTGACACAACAAGGTGCTGTATCCAAACTATTAGGTACACTAAGACCACCCGGCTTAATCGGTGGATCAAAGCCCAAAGTTGCCACACCAGCCGTTGTGTCCAAAATAGAACAATACAAGAGAGAAAATCCAACAATTTTTGCGTGGGAAATTCGCGAAAGACTCATATCTGAGGGTGTTTGTACAAATACAACAGCTCCATCGGTTTCATCGATTAACCGCATTTTGCGAAATCGAGCTGCGGAAAGAGCAGCGGCAGAGTTTGCGCGTGCTGCCAGCTATGGTATGTATCCAACACATCCATACACCAGTTTTCCAACATGGCCAACGAATATGCCCGCACACCATATCTGGCCGCCGAGTGCAAATTTGTGCAATGTTTTGCCGCAGAATCTGCCGTCGTCGACATCGTCAGCTAATTTACCGCCTACTGGCTTGCGTATTTCACCGCCGGCTCTTTCGTCTGAATCGGGTAGCCGTGACACTTTGTGTTCGCCGGACGAAAATCGCATGATagATATCGAAGGTGAAGACTCGGACTCACAAGATAGCGATCAGCCAAAATTTCGTCGCAACCGAACAACGTTTAATGCAGAGCAGCTCGAAGAGTTAGAGAAAGAGTTTGATAAGTCACATTATCCTTGTGTCAGCACTAGGGAAAAACTAGCCGCCAGAACAACACTCAGTGAAGCTAGAGTACAGGTTTGGTTTTCCAACAGACGAGCAAAATGGCGACGGCATCAACGCATGAATCTGCTCAAGCCCCGAACTTCATTATCACCGCCGAACTCAGCAAAATCGGAGAATCAACGACAATCACCCACATGCCATCAACTTACAACCAGAGAGTCACACAACAAGATCAGCTCATCACCTATACTTCAAAATCCACTACACGCCAGCAACTATCAAGTACCAGCAGCAAAAAATGCTTTCATCCCTACAAACGAACTCTTGACGCCCAATTTAATGCAAGGAACATCAGCTCTGCACACGATCAGCTCAGCCGATCAAACACCACAGTTGTCGGCAAACAATCTGCAGAAAACACCAGCGGAAGCCGTAGCAACACTGGCCTCACACACAGCATCAGTTCCATTATTAATGGGCGGTGAAAATAGTGCCTTCCACTCTCTGGCCAATGCCACACCTGCTGCGGTCTATGCGTTAAATCTCGCACGTCATTGTGTAGCTGCTGCTGCGGTCAACGCAAAACACCAACACCCCACAAACATATCGGCGAGCTCTTATTCCGATCAAGAGTCAGAAAACTCGGACGTAGAAATTAATGTCCTGCAGAATGAGGGAAGTGGTGATGAAAGCAAATGCAACAACCTTAACTAA
Protein Sequence: MASSVATATASGNVFTGGPPSPTTLSNLVSQHRLLELSRFGLRGYDLAQHMLTQQGAVSKLLGTLRPPGLIGGSKPKVATPAVVSKIEQYKRENPTIFAWEIRERLISEGVCTNTTAPSVSSINRILRNRAAERAAAEFARAASYGMYPTHPYTSFPTWPTNMPAHHIWPPSANLCNVLPQNLPSSTSSANLPPTGLRISPPALSSESGSRDTLCSPDENRMIDIEGEDSDSQDSDQPKFRRNRTTFNAEQLEELEKEFDKSHYPCVSTREKLAARTTLSEARVQVWFSNRRAKWRRHQRMNLLKPRTSLSPPNSAKSENQRQSPTCHQLTTRESHNKISSSPILQNPLHASNYQVPAAKNAFIPTNELLTPNLMQGTSALHTISSADQTPQLSANNLQKTPAEAVATLASHTASVPLLMGGENSAFHSLANATPAAVYALNLARHCVAAAAVNAKHQHPTNISASSYSDQESENSDVEINVLQNEGSGDESKCNNLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01414793; iTF_01180992; iTF_01181115;
90% Identity: iTF_01414793;
80% Identity: iTF_01414793;