Tmes016981.1
Basic Information
- Insect
- Tenthredo mesomela
- Gene Symbol
- TFAP2A
- Assembly
- GCA_943736035.1
- Location
- CALSEY010000200.1:666031-668289[+]
Transcription Factor Domain
- TF Family
- AP-2
- Domain
- TF_AP-2 domain
- PFAM
- PF03299
- TF Group
- Basic Domians group
- Description
- Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 4.4e-36 1.1e-31 111.7 0.0 84 195 13 122 7 124 0.95
Sequence Information
- Coding Sequence
- ATGGAGCGGCTCTTACTGGACTACATACCGCGCCAAGGAGGAGAGGCTATACACCTTGCTAGAGACTTTGGTTACGTTTGCGAGGCAGAATTTCCCGCAAGACAAATCGCCGAATATCTTAGCCGGCAGCATTGCGAACCCCAGGATTCTTACAGACGAAAAGAACTGCTCCATGCCACAAAACAAATCACCAAAGAGCTAATGGATCTTCTCAACCAGGACAGGTCGCCTTTGTGCAATACCCGACCACCGCATATCCTAGACCCAAGTATACAGCGACATTTGACGCACTTTTCACTGATATCACATGGCTTTGGAAGTCCAGCGATAGTCGCAGCTCTTACGGCGATACAGAATTTCCTTGGGGAGTCGTTGCAGCACCTGGAAAAAATGTATCCAGGAAATGGTAGTGGTGTAACGAGCAGCCAGCAGCCGAATCACGAAGGTAATAAGAACAACAAGGATGGATCCCTGATGAACGACATGAAGAAGTGA
- Protein Sequence
- MERLLLDYIPRQGGEAIHLARDFGYVCEAEFPARQIAEYLSRQHCEPQDSYRRKELLHATKQITKELMDLLNQDRSPLCNTRPPHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNFLGESLQHLEKMYPGNGSGVTSSQQPNHEGNKNNKDGSLMNDMKK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00939199; iTF_00868457; iTF_00676389; iTF_00280359; iTF_00279656; iTF_00867081; iTF_01244907; iTF_00128652; iTF_01234710; iTF_01453783; iTF_00127869; iTF_00182335; iTF_01421247; iTF_01411989; iTF_00718207; iTF_00719061;
- 90% Identity
- iTF_01421923;
- 80% Identity
- iTF_00939199; iTF_01411989;