Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 9.9e-05 4.5 8.8 9.2 1 17 31 47 31 51 0.94

2 4 4.6e-25 2.1e-20 75.6 5.9 47 119 56 125 47 128 0.85

3 4 1.5e-19 6.8e-15 57.5 7.2 183 272 138 231 125 250 0.76

4 4 0.027 1.3e+03 0.8 1.4 128 166 222 260 217 271 0.53

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	9.9e-05	4.5	8.8	9.2	1	17	31	47	31	51	0.94
2	4	4.6e-25	2.1e-20	75.6	5.9	47	119	56	125	47	128	0.85
3	4	1.5e-19	6.8e-15	57.5	7.2	183	272	138	231	125	250	0.76
4	4	0.027	1.3e+03	0.8	1.4	128	166	222	260	217	271	0.53

Coding Sequence: ATGGGTAACATGGCAGCAATTGGTGGAAGAAGTCGTGGTACTACAATACATGCGGCAGAAGATCATGCTCTTGATCAAATAGCAAAAGAGGCAGAAGCACGGCTGGCTGCACATCGGCAAGCTAGAGCAGAGGCGAGAGCTCGAACTAGAGACACTCCAAGCCGCACTGCAAGAGTGGCTTCCACCATGAGGACTGCATCGCACAGTGGTACCAATAGCCACCATTCAAGTCGGCATAGTTCCGAAGACTCCTTAGAGGAAGGCATCCGCTTAAGGGATGTACGGCAAGAACTGAAGGAAGTAGAGGAGAAGTTTCGCAAGGCAATGATTCAGAATGCTCAACTAGACAACGAAAAGTCCTCGCTTACGTATCAGGAACATGGTCGTATAATAGAAGGAAATGAACAGGTTTCCAGTGAAAAAGAAAGCAGTGATGAAGATGGTGTTACATCTACAAAGAAGACACCACATAAAGCACTAGTGTCTATAGAATTAGCTGAGTTGCTTAACAGTGCTGGTGAAGGCTCATTAGATGTAAGACTCCGAAGGTTTGCGGAAGAAGGAAATGAATTATTAGACCAGGTGGGGAATTTTAAGCTGGAACTGGAAGAAGAGCGAAGTCAATGTTGCACGCTTGGAAAGTCAGATGATAAGGGAACTGTTGAGAAAATAGAAGGTGAACTGAAGGTGGAGAAAAGGAGATTACAGAGAGAGCTTCGTGAAGCGCAAGCAAGAGTGGAGGAGTTAGAAACGTTGAATACACATCTGCAGTGTAGACTAGACAAGTTGAACAATGCAAAGTCCGCAGCGCTTATAGAACTTTGA
Protein Sequence: MGNMAAIGGRSRGTTIHAAEDHALDQIAKEAEARLAAHRQARAEARARTRDTPSRTARVASTMRTASHSGTNSHHSSRHSSEDSLEEGIRLRDVRQELKEVEEKFRKAMIQNAQLDNEKSSLTYQEHGRIIEGNEQVSSEKESSDEDGVTSTKKTPHKALVSIELAELLNSAGEGSLDVRLRRFAEEGNELLDQVGNFKLELEEERSQCCTLGKSDDKGTVEKIEGELKVEKRRLQRELREAQARVEELETLNTHLQCRLDKLNNAKSAALIEL

Sequence clustering based on sequence similarity using MMseqs2