Basic Information

Insect: Tenebrio molitor
Gene Symbol: MBD-R2
Assembly: GCA_963966145.1
Location: OZ014542.1:5101315-5107048[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.2e-16 7.7e-13 48.5 0.1 8 71 386 448 380 454 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.2e-16	7.7e-13	48.5	0.1	8	71	386	448	380	454	0.92

Sequence Information

Coding Sequence: ATGGGCCGAAAGTGTGGAGTTGAAGGTTGCTTATCTGATTCTAGCAGACCTGAAGATACGGGGGTAACATTCCATAAAGTACCCATGCACAGTGACATTCGTCCAAAATGGATTTCATTATGTCGAATACCTgatgacaaaaaaaacatgaaagtGATATATATTTGTTCGCGTCACTTTCTGCGAAtggatttttgtaattttaaaggaaaaaaatatatgttgcGTCAAGGAGTACTCCCTAGTGTGTTTCCATGGGATAAATCTAAATTAGAAGCTATTAAAAGCAGTGTAAGAAATGAATCTGAAAAAGGACAAGTTAAGGAAGATGGTAATGATGAAGAAACAGAAATAAGTGAAAGTGCTCTTGGCAATCAAGAAGAACAGTTAGAAGTTAAAGAGGAAGTTATAGATACTGAGTCAAGTAAAGAAGAAACTGAAGatgaaaaggaaaaaattagGGCTAATATGAATGGGCCAATcaattttgcaataaattcTAGAATTGAGGCTTTAGATAATAACAATACATGGTATCCAGCTAGAGTAGTTGAAGAAGATTATGAAGAGAATGAAGTTTtgattcattttgaaaaattttcaagcAAATATGATGAATGGATTTGCATGGACAGCCCTAGATTGAGACCTCTACAATCTTCAACATCTTCATCTTCACAGTCTTCTACCAAAAAGAGTCAACCTGAACAGTATGCAGTAGGAGAAAGATGTTTAGCTTCTTGGAGTGATGCTAGGAAATTTCCTGCTACTGTCACAAAAGTTTTAGCAAatgATACATATGAAGTTTTATTTGATGATGGGTTTGTGAAAAATTTGAAAGCTCATCGCATGTGCAAATCTGAAGGCCGTCCAATGCAGTCTTCACCATTGTTTGACCCCATACAGAGTTCAAAGCAAGAACGTAGggagaagaagagaaaaatCAATGTTGCAGAATTATTTGGGAAAAGACCAAGGGTAGATAATGCagatgaaaaatcaaaaatagtcCAACCTCAACATTCATTGTCAAGTGCAACTTTATCAGatgaaatatttgaaccttggGTGCCACAATGGGAAGGTGGAAAACCAGTTGGTATTGAATCATCAATAGAGGCACATGATGGGACTAGAAAATCAATTATTGTGCCAGATCCTCGATTACCAGAAGGATGGTCTAAACATTTGGCACAAAGAACACATGGTGCCTCAGCAGGAAAATGGGATACTATAATTGTTAGCCCTGACAACAGAAGATTTAGATCAAGAACTGAAGTTAAAGCCTACTTGGAAGAATCGAAATTGATGAAGTACAATTGGTCAATGTTTGACTTCAGTTTGCATAGACatcgaaacagaaaaaaagatATTGAATCAGAAGCAACTCGATTGTCGCAGGAAGCACCGACAGAAACATTTGAACATGAAGAAACTTCAGAATTGGTGACTGAAGAAGAAGAAAATAAGAATTATCTGAAAATACCGATTGTTGACGATGCGTACCAGTGCCCTATTGAAGGTTGTGGGAAAACTTACCGAAAAGAGAATTTAGCTCAAATGCATGTGAAACATTATCACCCTGAATATACCAAATTTCTTGATTCCACACCAAACGTCGCCGATTTGGCTTACGCGAGAACTGTTGGAGAGTCGTTGGATAAATCGCCGGGTGTCAAAACACCTGTGGCCAAACCTCTACAAAAATCTACAAATCTAAGATCATCAGCAAAGTTGTCGCAATCACCACAGATGGAGTCAGAGAGCAAACCTCAGTCTCCTCTAccttcaaaaaataaagattcCGAAATCATCAAACTGTTGAATACAAAACCATTTGATGGTAAAAAGGATAATGATGCGATTAAACCTTTACCGGCGGGCCTGCCGTCTAACATGTATCCAGATATTAAATTGAAAGATCTCCTTAACAAGTCCGAGGGTATCCCTAATCGCGACGATCTCAATTTACGAGCCTTAAGTACAACTAGACCTCCAACAGGCATAAAAACTTTATTGCCTGTCACTAGatcagaaaataaaacaagtcCGCAGTTGCCTGATTCCGAACCtgttaataacaaaataaagtcAAGTTTGAAGCGTAAGCGAGGATTAGTCGACTCGGTCGACAGTCCTAAAGGTAATGAACCGCTAGAAAACACGTTGATTCCACAGGAAACACCACCACTTCCAGAACCTAATAACATTATTATTGAAGGTGGTCAGGTGATCAAAATTGTAAGAATGAAACAAGAAGAAATCATCAACTGCACTTGCGGCTACACAGAAGAAGATGGTCTCATGATTCAGTGTGATTTGTGTTTGTGTTGGCAACATGCTTTCTGCAATAATATCGAGCGCGAAAGTCAAGTACCTGAAAAGTACGTTTGCTGCATCTGCCAAAATCCAGCGAGACAGAGAATGTCTAAAAAGTATTATCACGACCAGGATTGGTTGAAACATGGTATCCTCGCCACCACAAATTTTCACACCAAAGATGAAGAAGCGCTGAGCAAgagatttgaaaaattaaaaaaatctcacGATATCTCTGGAGGATTACTTGAAGTCAGGGAGTTTGTAAATTCTTTAAAGgttaaattgaaaatcgccgaAGCAAAAAATCACCCAAAATTGTATTTGTGGTCTAAACCTTGGGAAAAATTACCTTTACcagaaaaaatatgtttcaaaaGCGAAGACGTAAAACCAAAGACTGAAAAATGTGAAGACGACATAAAAGAAGAGAATTCTGTGAAAACCGAACAGTCTGATTCTATGTTGATGATGATATTAAAAGGTACCAAAGAAGAAATAGAAGAGAATCACATAGCAGATGACCATTTAGACAGTTTGCCAGCTCCCATTATCCCACAACCGGAAGCAGCTATCGATTCAGCCGATTGTCGTTTAAATTTGTTGGATCACATTGCGCATTCTCAATCGCTGGTTGAGCAAAGATTAGACGATTTTGAGAAACAAATAGAAAGTTTGGAAGACACCACCCTATATTATGAAGACGATGAAAATTATCCTCGAACTAGACAAACTCTGAATATGCTTCTCAGAGATTTAAATACGTTGCAAGAATTAAGTCAGTTAACGACATTATGA
Protein Sequence: MGRKCGVEGCLSDSSRPEDTGVTFHKVPMHSDIRPKWISLCRIPDDKKNMKVIYICSRHFLRMDFCNFKGKKYMLRQGVLPSVFPWDKSKLEAIKSSVRNESEKGQVKEDGNDEETEISESALGNQEEQLEVKEEVIDTESSKEETEDEKEKIRANMNGPINFAINSRIEALDNNNTWYPARVVEEDYEENEVLIHFEKFSSKYDEWICMDSPRLRPLQSSTSSSSQSSTKKSQPEQYAVGERCLASWSDARKFPATVTKVLANDTYEVLFDDGFVKNLKAHRMCKSEGRPMQSSPLFDPIQSSKQERREKKRKINVAELFGKRPRVDNADEKSKIVQPQHSLSSATLSDEIFEPWVPQWEGGKPVGIESSIEAHDGTRKSIIVPDPRLPEGWSKHLAQRTHGASAGKWDTIIVSPDNRRFRSRTEVKAYLEESKLMKYNWSMFDFSLHRHRNRKKDIESEATRLSQEAPTETFEHEETSELVTEEEENKNYLKIPIVDDAYQCPIEGCGKTYRKENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGESLDKSPGVKTPVAKPLQKSTNLRSSAKLSQSPQMESESKPQSPLPSKNKDSEIIKLLNTKPFDGKKDNDAIKPLPAGLPSNMYPDIKLKDLLNKSEGIPNRDDLNLRALSTTRPPTGIKTLLPVTRSENKTSPQLPDSEPVNNKIKSSLKRKRGLVDSVDSPKGNEPLENTLIPQETPPLPEPNNIIIEGGQVIKIVRMKQEEIINCTCGYTEEDGLMIQCDLCLCWQHAFCNNIERESQVPEKYVCCICQNPARQRMSKKYYHDQDWLKHGILATTNFHTKDEEALSKRFEKLKKSHDISGGLLEVREFVNSLKVKLKIAEAKNHPKLYLWSKPWEKLPLPEKICFKSEDVKPKTEKCEDDIKEENSVKTEQSDSMLMMILKGTKEEIEENHIADDHLDSLPAPIIPQPEAAIDSADCRLNLLDHIAHSQSLVEQRLDDFEKQIESLEDTTLYYEDDENYPRTRQTLNMLLRDLNTLQELSQLTTL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01410052; iTF_01568009; iTF_01567905;
90% Identity: iTF_01410052;
80% Identity: iTF_01410052;