Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.029 1.8e+02 3.6 0.1 6 27 17 38 13 50 0.80

2 3 4.5e-13 2.8e-09 38.2 8.3 4 67 109 171 106 174 0.91

3 3 6.7 4.2e+04 -4.0 1.2 5 11 324 330 321 331 0.63

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.029	1.8e+02	3.6	0.1	6	27	17	38	13	50	0.80
2	3	4.5e-13	2.8e-09	38.2	8.3	4	67	109	171	106	174	0.91
3	3	6.7	4.2e+04	-4.0	1.2	5	11	324	330	321	331	0.63

Coding Sequence: ATGATTAAAGCTGAGCGACCGGACACGTGGAAATTGCACGGCGAGAGGAAAGTCTGCTCCCAATGCCAGAGGAAAGCTATGCCGACACTTCATACGGGCGGCGACAAACTGACGACCTCACACATCGGAGCCCCTCTGTCTTTTCGGAAAACAGCGCGCTTTTGTAAATCACAAAGGGCGGAATGCAAGCGGAGCGGGCCGTCGCAGAGTGGCATGCTGCTCCCGTGGATTCCGACACTGAAAGCGCCCGATGGTAAAACTCGCGCGCCGAAACGGCCGAACAATGTTTTCTCCACGGAAGTTGAAATATGGAAATACCACGATGAATCGATGCGTTGTCCGGCATGTGGCGTGAAGGACGTGCCGATAATACTAAAACAGCAGAAATTTATGAGCTCCCGATTGGCTGCATTTTGCTTAATGGGATGTTGGCCCTTCTGTTTTATACCATTAATGATGAGACGAGACAAAAGCGTGCGCACGCTATGCCCGTGTTGCGGCCACGATTACGGAATTTGTACGGGAGCGGAGAGCAAGCTGATCGCCTGTTCGCCCGAATGCGCGTCTAGCCGCGGGAAATTAAGTGATTTCGCAAATTCACGAACGTGTCATCTTCGGGCGGAGTGCGGCGGCTCGCGAATGGAACCAGGACGTCGTCAGAAAACACTTTCCATGGGTGACGAGGCTGCGAGGACTCTCAGGGTCCCGGAGAAGCGTCCTCGGCGAGAAGAAGGCGGATCTCGTCGCTGCCGGTCGCAATCGAAGTTATCGCGCGGATACGCCTTTTGTGCGAACCAGGTCACGAATCGCGGTTCACCATATGACGAGTATAGCAGCGAGGATTGCGTGGACGACAAAAGATGGGATCGTCGGCGCGACTTGGACGAATCGAGAGCTTCGAAAGCTCGGGGACAAAGCGAATCCGAAGGCAGCAGCGCGGGGACGGTGACGGGCGATTTTTATGCGAGACAGGTTTGCTGTCGGGAGTGCGGCTAG
Protein Sequence: MIKAERPDTWKLHGERKVCSQCQRKAMPTLHTGGDKLTTSHIGAPLSFRKTARFCKSQRAECKRSGPSQSGMLLPWIPTLKAPDGKTRAPKRPNNVFSTEVEIWKYHDESMRCPACGVKDVPIILKQQKFMSSRLAAFCLMGCWPFCFIPLMMRRDKSVRTLCPCCGHDYGICTGAESKLIACSPECASSRGKLSDFANSRTCHLRAECGGSRMEPGRRQKTLSMGDEAARTLRVPEKRPRREEGGSRRCRSQSKLSRGYAFCANQVTNRGSPYDEYSSEDCVDDKRWDRRRDLDESRASKARGQSESEGSSAGTVTGDFYARQVCCRECG

Sequence clustering based on sequence similarity using MMseqs2