Basic Information

Gene Symbol
-
Assembly
GCA_949987645.1
Location
OX465274.1:21755680-21767510[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0014 0.17 13.9 0.0 1 23 139 162 139 162 0.97
2 12 0.0063 0.8 11.8 3.3 2 23 211 233 207 233 0.88
3 12 0.011 1.4 11.0 1.4 1 23 361 384 361 384 0.93
4 12 0.078 10 8.3 1.5 2 23 434 456 433 456 0.91
5 12 0.015 2 10.6 0.1 1 23 557 580 557 580 0.91
6 12 0.0012 0.16 14.0 2.4 2 23 631 653 631 653 0.97
7 12 4.8e-05 0.0061 18.5 0.5 2 23 770 792 769 792 0.96
8 12 0.00016 0.021 16.8 0.1 1 23 841 864 841 864 0.95
9 12 0.0029 0.37 12.9 1.4 2 23 914 936 913 936 0.95
10 12 0.096 12 8.1 2.2 1 22 1011 1032 1011 1034 0.90
11 12 1.2 1.6e+02 4.6 0.4 1 20 1086 1105 1086 1107 0.94
12 12 0.041 5.3 9.2 0.0 2 23 1187 1209 1186 1209 0.95

Sequence Information

Coding Sequence
ATGGATAATTTAGAGCCTTGGAATATGTTTAGCAATGAGTTAATGGCAGGTGAAGAAAATGTAAATGATATTGAAGCGGGTGGAGTGCGGGATAAAAATGTGTCTTTTTCTATTCCTTCACCGGTACAAAATATGCATGTTAAGGAAGAACCTCAAGAGATTCTCGATGATGACAATGACAATGTTCCACTTCACTTCCTTGCAGGAAGAACCAATAGAAATTACAATAATAACGACATCCAAATTAGAAACACCGATGACGATAACGCTCTTTTTGATTTCGGTTTAGAATCATCAAATTCGCAGAATCGAACTTTTTTCAATAAATCGGCGGTGGCCGAGAAAGATTTTCCCAAGTTAGAGTCAGAGGACAAATACTACAATTCAATGATTAAATTTGAAGACGCTATAATTTATATATGTCCTGCTTGTGGTAATGAATTTAGCTCTCAAGATGCTTGGAAAAATCACTTGAACGTAATTCATCTATACAATACACGTCGCGGtctaaattttatacaaatcgACAAACTGTACCATGAATGTATGGAATGCCACAAACGTATCGCTATGCATAGCATGGAAAACTTACTTAAGCATAAATTTACCCATCTTCCCTATCGGTGCAGCAAATGTATGGTGTGTAATAGACAATATAAATATCGGCAAGATCTTATGGTACATTTGCGTATGACCCACCGTGACGATTTAATAgaacttttgaaaaaagaacATAAAAGTTCTAAAACGTCCAATTCCCAACCCCAAACTATACGCTCAATATTGAGCAGAACAGATGGTAGCACCAATATACCAACTATTGCTATTGGAACCGTTAAAGAAAATGCTAAAGATTTATTCGACAATATAGAAGTGAAAAATGAACTAATTAATGAAGATGATGATACAATGGGCGAAGATAGTCAACTGCCGCCAATAAAAACACCAGCTAAAGATTTACCCGCCTTTCTTGAAGATGGATCTACAAATGGTTCAGCTAGCGACCAGCCAATGACAAGTGGATCTAATAAAGCTGTGGAAGTAGATGAAATAGATGTTTCGCTTGAAGAATATGTTTTGTTCACATGCCCACAATGTGGCACGGAGTGTGAAACTCAAGCCCAATGGCATCAACATATCGAATTTGTACATGAATTTGGCACGCGAAGAGGATTGAATTTTCGAGAGCTGCTTAATCAACAAGCTCAGTGCATGGGTTGCAATATGATCTTGTCTAACACTTCAATACGTAATCTTCAAGTACATAAATTCAGTCACTTACCATACAAACAATGGATGAGTTGTAAACTTTGTTTTACCTCCTTCAATTCAAATCATGAGATTATTAAGCACTTGGCAGCTAAGCACCATTTAGTGCCGGAGATCGTTAAGCCAGCTCCAGTTGTAGAGGTAAATAACGACGATGAAAGTCAAGAAGCATTTGGTTTTGATAATGTTGGCGATTCCTATGGAGGTTTTGGTGATGATGATTATGGTGTTGGGGTAGGTCGAGGTGGAGGTGTTAACAGTGGTGGCGGTGGCAGTGTCAGTGGCAATGGCAATGGTAATGACGGCTACGGAACCTCCGAAAGAAAAAATCCAACATCAGGTTCAGACTCCCAGCCAATAAAGTATGATGAACGTGATGTGTTCGAACAGCATATAACGTACATTTGCCCGGCGTGCGGTAAAGAATATAACGATAAAAAAGTCTGGCGAAAACATATTGTAGAAGTTCATAAGTTGGGCGAActggaaaatttgaatttcgaaaatttaaaTGATCGTCAATTGAAATGTAGAGAGTGCGACAAGATTATAACAAATGCATATGGTATACAAAATGCCCAACAGCATCGTATGACCCACTTGCAATACAAATCGTTTGCAAAATGCCGTTTATGTAGAAAAACTTATACCGACCGCAAGGGTTTAATCAAACACTTGAGAAACTCCCATAAACTGGGTGCTCGGGTAGGTTTTGGTCCACCTCATCCAGCACCAGTAACCGCACCAGCACCAGCATCAGCAACTACAAATTATACTGGCTCAAGCAATAGTTCCACCTTTAAACCTTTTGTTAAGAAGCCGTACAAGATTGCTCACTATCCACCTAAAGAAATAGTTAGATTATCAAATTACACTTATGAAATTGTACATTTGATCGAAGACgacgacgatgatgatgatgtgaCTATTACCGGTGGTTATGACTTTGCCAAAGGTGATGctcatttatataaaaacaattcacCTTATAATACGCCTTCTAAGAGAAGCAGCAATATGGAACAAATAACCAGAAATAAATGTGTAGACTGTGGTACTATATTTCCTACTCCACAGTCCCTGCAACATCACATTCGGCAAGAACACGAATTTGTTGATTATCAAAATTCGTCGTCTACTCAGGCGGctcaaaatgaagaaaaatcaaaCGACACTGATGATTTATTAGTGCCAAGTAGAAATGCTGATGTCCAACCCGAAGAACCCACAACAATGGaatgcaattttatttatctGTGTCCCCAGTGTGGTTTGGAATTTCGTTCACAAGTAAAATGGAGGCGTCACATTAACATTGAGCATAACTTTGACCAACGGGTCTCGTTGGGCTTCAGGCCTTTGGACAAATTTCGTTATCAATGCAGAATTTGTAAGGACACAATAACGAGTTCGAAACTAAAGGGTTTGCAGGATCATAAATTTAGGCATTGTCCGTATAAACTCTATCTGAAATGTCTACTGTGCGGCCAATCGTACAATCACAAACCCAATATGCTGGCCCATTTAAGGCAAAAACACAATATTGTAGAGGTAATGGAAGGTGGGACGGTATCGTCTTCCAACGACAATACGCAACCACGTCATTCATCTAATTCGAACAATAAAGATTTTAATGATGCTCCAGCCAGACCGATTCGAAATTCCGATCCTTCCTACAATAACGCAAACCGACCACCTGGCCTAAAGACAGTTGAAGATGTTATATCCTTTCACAACGCCGTCGATCACGAAACTATTACATACCACTGTCCGTCGTGTAATCAAAGTTTCGATTCTCATGTGTTTTGGCGCAAACACATTGTAGACGAGCACAATTTGAATAGCAGAGAAGGCTTGAATTTCCGTCAATTGGATGAACATCACTACATTTGCTTGCAATGTTACAAACGTGTAACAGTTACTCACACTAAGGGCGCAATCGGCCAACTGCAGTCTCATAAGTTTAGGCATTTGCCATACAAGTCATTCAGTTGTACTGCCTGCGAGGGAGAATTTGTACGCAAGCAGATGTTTTTCAAACACTTGGACAGAAATACCAACAAATGCTCTGGCATAAATCCTGATAACAATTTCACAGATTCTGTGGACAATAGCACATCTGTAAATAATGACGATGTGGGAAATGATGATCTAAGTTCGACATTGGCTGAGAAAGCTGGCTCTTCTTCAACAAAATTCTCTTGGCCCACGCGCTCCTCACTGCCAGTCCAGCCGACAACTGCTGGCAATAGTGAATCAATTTCAGATAATCAGGGTTGCTTCACTTTAAACTGTCCCCAGTGCGGCGCAGATTTCGAAACGACGCGTGGTTGGCGGGAACACATAAATATCGAACACAATCTCAACAATAGAACTGtattgaatttcaaaaaaatcggTGCCAAACTACACCTTTGTTTGGAGTGCAACGAACAAGTCAATGGTAGGAAACTTCGCGATCTTCAAGTACACAAATTTAAGCACTTACCCTACGGTGCTTATTTGCACTGTCGCTTTTGTTCtatgaaatatttccatatcAGCAATATGCAagagcatttgaaaaataaacatcCTAATATGGtgcaaaaaatgaaaaactatgAAGATGATTGTGGTACTTTAGATGAAGATGATGATGCCAACGTGGATGGCGATGGCAATGATGCCGATGCCGATGCCACGCTGGACGGGGAGGCAGATGACAGTAATACCGGCTTGGAAGATGGAATCGATATAGATTTGTTAGAGGCCGAAGCCGAAATTGAAGAAGTCGACCCTGATAATGTAGAATCTGAGGAACAATATCTCTTAGGCTAA
Protein Sequence
MDNLEPWNMFSNELMAGEENVNDIEAGGVRDKNVSFSIPSPVQNMHVKEEPQEILDDDNDNVPLHFLAGRTNRNYNNNDIQIRNTDDDNALFDFGLESSNSQNRTFFNKSAVAEKDFPKLESEDKYYNSMIKFEDAIIYICPACGNEFSSQDAWKNHLNVIHLYNTRRGLNFIQIDKLYHECMECHKRIAMHSMENLLKHKFTHLPYRCSKCMVCNRQYKYRQDLMVHLRMTHRDDLIELLKKEHKSSKTSNSQPQTIRSILSRTDGSTNIPTIAIGTVKENAKDLFDNIEVKNELINEDDDTMGEDSQLPPIKTPAKDLPAFLEDGSTNGSASDQPMTSGSNKAVEVDEIDVSLEEYVLFTCPQCGTECETQAQWHQHIEFVHEFGTRRGLNFRELLNQQAQCMGCNMILSNTSIRNLQVHKFSHLPYKQWMSCKLCFTSFNSNHEIIKHLAAKHHLVPEIVKPAPVVEVNNDDESQEAFGFDNVGDSYGGFGDDDYGVGVGRGGGVNSGGGGSVSGNGNGNDGYGTSERKNPTSGSDSQPIKYDERDVFEQHITYICPACGKEYNDKKVWRKHIVEVHKLGELENLNFENLNDRQLKCRECDKIITNAYGIQNAQQHRMTHLQYKSFAKCRLCRKTYTDRKGLIKHLRNSHKLGARVGFGPPHPAPVTAPAPASATTNYTGSSNSSTFKPFVKKPYKIAHYPPKEIVRLSNYTYEIVHLIEDDDDDDDVTITGGYDFAKGDAHLYKNNSPYNTPSKRSSNMEQITRNKCVDCGTIFPTPQSLQHHIRQEHEFVDYQNSSSTQAAQNEEKSNDTDDLLVPSRNADVQPEEPTTMECNFIYLCPQCGLEFRSQVKWRRHINIEHNFDQRVSLGFRPLDKFRYQCRICKDTITSSKLKGLQDHKFRHCPYKLYLKCLLCGQSYNHKPNMLAHLRQKHNIVEVMEGGTVSSSNDNTQPRHSSNSNNKDFNDAPARPIRNSDPSYNNANRPPGLKTVEDVISFHNAVDHETITYHCPSCNQSFDSHVFWRKHIVDEHNLNSREGLNFRQLDEHHYICLQCYKRVTVTHTKGAIGQLQSHKFRHLPYKSFSCTACEGEFVRKQMFFKHLDRNTNKCSGINPDNNFTDSVDNSTSVNNDDVGNDDLSSTLAEKAGSSSTKFSWPTRSSLPVQPTTAGNSESISDNQGCFTLNCPQCGADFETTRGWREHINIEHNLNNRTVLNFKKIGAKLHLCLECNEQVNGRKLRDLQVHKFKHLPYGAYLHCRFCSMKYFHISNMQEHLKNKHPNMVQKMKNYEDDCGTLDEDDDANVDGDGNDADADATLDGEADDSNTGLEDGIDIDLLEAEAEIEEVDPDNVESEEQYLLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00742345;
90% Identity
iTF_01397996;
80% Identity
-