Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.64 1.1e+03 -0.1 4.4 48 65 70 87 55 92 0.70

2 3 9.1 1.6e+04 -3.8 0.7 59 63 167 171 164 173 0.49

3 3 1.2e-09 2.1e-06 27.9 6.3 5 70 185 253 181 253 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.64	1.1e+03	-0.1	4.4	48	65	70	87	55	92	0.70
2	3	9.1	1.6e+04	-3.8	0.7	59	63	167	171	164	173	0.49
3	3	1.2e-09	2.1e-06	27.9	6.3	5	70	185	253	181	253	0.85

Coding Sequence: ATGGCCAATAATCGAGAGAACAAGGCTTCAAAGAAACCCTCCGATGAAGGCTCAAATCGACCAAAGAAATCCTATCCATCGCCATCGACTTCAAGCGATTCTTTCAGCAGCGAAGCACTTCGTCGAGCCGAGCTTGAGGCTGCACGATTCGACCTCAAAAATGAATGTAAATGTCCTTGCAGCCTAAATCCGTCGGGCAAATATCCCTGTCGACCATCCCTTCGATCAGATATCAAGTATTGTACGAAATGCAAGAAATTAACTCCGAAGAATCGGATTGAAAACAGTCTTTCGAACATGCAGCTCATAAAGCCAGCCACCGAGAAGAGTGAAATCCAAGGTGAAGAGCCTTCTGATGACTTTCTACGACCCGCCTCGCTCTTCAGAGACTTGAAGCTTGAGTACATTCCGGTTGACTATTCACCCCCAACCCGGCCTCTACCGCCAGCTCCCCTACCGCCCCCACCCCCACCACCACCAACTTTAGAAAAACCCAAGTGTCACACGTGCAAATATCGCAGGGCACTCGAGAATTGGAAACCGCTAGAAGGAAAACTCTACTGCCCTCGATGCTGCTCAATGGAGGTTCCCATTTTGCGGACAAAAACCAAAAAATCCGGCTCAACGATATACGAGACCATGAGCAGTCGATGCTTCACCCACTGCTGGCCGCTGTGTTTCATGCCGTTCCTATTTCTATCGCCCTCGGAAAACTACCTTCACTGTGCGGAATGTTTCGCCTACCTCGGGATGTATGACGAGCAGAAGAAGTGCATCGTGCCGAATCCGGACTTCATTGAAAACGACGGATGCTTCGTCCTGAAGACTTCCAAGCGACGGGGGCGAGAACGAGCGAAGCTCGACGTCTGGAAGGAGCTCAGCTTTCATTAG
Protein Sequence: MANNRENKASKKPSDEGSNRPKKSYPSPSTSSDSFSSEALRRAELEAARFDLKNECKCPCSLNPSGKYPCRPSLRSDIKYCTKCKKLTPKNRIENSLSNMQLIKPATEKSEIQGEEPSDDFLRPASLFRDLKLEYIPVDYSPPTRPLPPAPLPPPPPPPPTLEKPKCHTCKYRRALENWKPLEGKLYCPRCCSMEVPILRTKTKKSGSTIYETMSSRCFTHCWPLCFMPFLFLSPSENYLHCAECFAYLGMYDEQKKCIVPNPDFIENDGCFVLKTSKRRGRERAKLDVWKELSFH

Sequence clustering based on sequence similarity using MMseqs2