Basic Information

Gene Symbol
topi
Assembly
GCA_900474325.1
Location
UCOK01015973.1:47539-49335[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.092 11 7.3 2.5 1 23 89 111 89 111 0.97
2 16 1.6 1.9e+02 3.4 2.9 1 23 116 139 116 139 0.83
3 16 0.029 3.4 8.9 0.2 2 21 146 165 145 166 0.92
4 16 3.9e-06 0.00045 21.1 1.7 1 23 173 195 173 195 0.97
5 16 1.2e-07 1.4e-05 25.8 1.2 1 23 201 223 201 223 0.96
6 16 0.00085 0.097 13.7 0.2 2 23 235 256 234 256 0.95
7 16 0.085 9.8 7.4 1.2 1 23 272 294 272 294 0.97
8 16 6.2 7.1e+02 1.5 0.7 1 12 300 314 300 317 0.79
9 16 2.1 2.4e+02 3.0 5.1 1 22 332 353 332 356 0.89
10 16 0.0099 1.1 10.3 0.2 1 21 369 389 369 390 0.95
11 16 0.0078 0.89 10.7 0.2 1 23 395 417 395 417 0.95
12 16 3.4e-06 0.00039 21.2 2.3 1 23 423 445 423 445 0.98
13 16 2.1e-05 0.0024 18.8 0.5 1 23 451 474 451 474 0.98
14 16 0.024 2.7 9.1 1.2 1 23 480 502 480 502 0.89
15 16 2.6e-06 0.0003 21.6 3.6 1 23 508 530 508 530 0.99
16 16 1.1e-05 0.0013 19.6 5.4 1 23 536 559 536 559 0.96

Sequence Information

Coding Sequence
ATGAGTGGAGATGAAGACACAAAAATGAAAgttcttaatgaatttttaatttggtcGCAAGATGATCCAATTTCGTCAAACGAAATTTGTGAATTACCATTCAAATGCTGGAAGGAAACCTCTGGAAGTTCTGCAATAACTCTCCAGTGTCTAGGAAGCACCGAAACAAACTTTAAATGTGGAGCTTGTATGAATCTTTACCACACGAAAGAAATGCTTAAGACTCACAAGTGCAAACttccaattgaaaataattccaagCCCTACGTTTGTACTCTCTGCGAAGCAAAATTCAACTTCGAGGAACATCTAAACTTCCACCTCAAATAccataatttaaaagctttctaCTGTGAAATCTGCAAAATAAGTTTTGGAAAAGAGCTTCAATTCTTTTTCCATTATAAAAGATATCATTCTAAAGAGAAGGTTGTATCCTGTCTTCAATGTGGAAAGCTTTTCCAGGAACAGGAGGAACTTAAAATTCACGTTTGTGTTGATGGAAAAGCAAAGCCTCACGTCTGTGAGGTTTGCAATAAAAGATTTTCCGATGGCTACACTTTGAAAAGACATCTTATTACTCATCTTCCAGAAAAACCTTATAAATGCAATGAATGTCCTAAGAGCTTTACCCAAAAATCAAGATTGAATAAACATATCGCTGATCATGAAGTTATGATGGAGAGTTCTCAGAATCTTTGGAAATGTATGGATTGTGGAAAAGTTTTTGGCACGTTAGAAGAAGCTgagaaacattttcagaatcatGATCAGAAGATTCTAATTGTTGAGGAAGTTTCGGCGGCGAAGGTCTACCAATGCGAATTTTGTAACAGTTATTTTGTGGAAAGGGAACTCATGAAAATTCATCGAAGTCAACATCGTTTGGAAAAGGCTTATGAGTGTCAGGATTGCAGGATGGTTcataaatgtttttctcaAGCTGTCATGGATTGGAAGCAACATCAGAAAGCTTTTAAGatTCAGGTCCTCTTCATCTGCGAAATCTGCAAAACGGAAGTGAAACACCTTCACGTCCTCTACAGGCACTACCACAAAAAACTTCACTATCTCCCTCGATCAACGGAATACGGAACAGGAAAATTCGCCTGTGAACGCTGTGGATCAGTTTTTCAAGATCTCGACGAATTCAAAAATCACAAGAGGGACCGTTGTTCAAAATTCCTCTGCGACATCTGTGGAAATTCTTTACTTTCCGCAAGTTCCTTAAATGCTCACAAAAGACGTCACAGTGGACTCAAGCCCTACGTTTGTAATATTTGTGGAAAAAGTTACACCCAGTCGGGTCATATGTGGACTCacaaaagatttcatatgGGGATCAAACCTTATGTTTGTCAATACTGCGATCAAAAATTCACAATCAAACCCGATCTAGCTGATCATATAAGGAAAAAACACACGAGGGAAAGGCCTTTTAAATGCGAAGTTTGCAATAAAACTTTTCTCACTGGATCAGTTTTTTATCAGCACAGACTTATTCACACCGGCGATAGAAGATATAAATGTTGTTACTGTCAAAAAGCTTTCACAAGGACTGAGGCGTTgaaaaatcatattaaaattcatacggGAGAAAAACCTCATGCTTGTGAtgtttgcgggaagtgttttAGACAGAAAGGAGATATGAAGAAACATAAGAAAACTCAACATACTGAAAAAGTTGTAGAATTATAG
Protein Sequence
MSGDEDTKMKVLNEFLIWSQDDPISSNEICELPFKCWKETSGSSAITLQCLGSTETNFKCGACMNLYHTKEMLKTHKCKLPIENNSKPYVCTLCEAKFNFEEHLNFHLKYHNLKAFYCEICKISFGKELQFFFHYKRYHSKEKVVSCLQCGKLFQEQEELKIHVCVDGKAKPHVCEVCNKRFSDGYTLKRHLITHLPEKPYKCNECPKSFTQKSRLNKHIADHEVMMESSQNLWKCMDCGKVFGTLEEAEKHFQNHDQKILIVEEVSAAKVYQCEFCNSYFVERELMKIHRSQHRLEKAYECQDCRMVHKCFSQAVMDWKQHQKAFKIQVLFICEICKTEVKHLHVLYRHYHKKLHYLPRSTEYGTGKFACERCGSVFQDLDEFKNHKRDRCSKFLCDICGNSLLSASSLNAHKRRHSGLKPYVCNICGKSYTQSGHMWTHKRFHMGIKPYVCQYCDQKFTIKPDLADHIRKKHTRERPFKCEVCNKTFLTGSVFYQHRLIHTGDRRYKCCYCQKAFTRTEALKNHIKIHTGEKPHACDVCGKCFRQKGDMKKHKKTQHTEKVVEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01390549;
90% Identity
iTF_01391424;
80% Identity
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