Basic Information

Insect: Synergus itoensis
Gene Symbol: PAX6
Assembly: GCA_904066005.1
Location: CAJFCP010000685.1:214043-224168[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.1e-74 2.5e-70 235.0 0.6 1 125 34 158 34 158 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.1e-74	2.5e-70	235.0	0.6	1	125	34	158	34	158	0.99

Sequence Information

Coding Sequence: ATGCCGCCCCCGCAGGAGGACTTGATGCACGGGGGTGGAGCGGGCATTGGAGGGGGTTCTATGGTTGGACAGAACTCAATATTTGGGTGTTCGGCTGCAGGACACAGCGGGGTTAACCAACTCGGTGGTGTTTACGTCAACGGAAGGCCATTGCCGGATTCCACGAGGCAGAAGATTGTCGAATTGGCTCACAGTGGCGCGAGACCTTGCGACATTTCACGGATTCTGCAAGTCAGCAATGGATGCGTTTCAAAGATCCTCGGAAGATACTACGAAACAGGCTCAATAAAGCCACGAGCGATTGGCGGAAGCAAACCACGCGTGGCGACAACACCAGTCGTGAATAAAATTGCCGATTATAAACGAGAGTGTCCCTCGATCTTCGCTTGGGAGATCCGGGATCGATTGCTGCAGGAGGGAGTCTGCAACAATGACAATATTCCAAGTGTGTCATCTATAAACAGGGTGCTGAGAAACTTGGCTTCGCAGAAGGAGCAACAAGCAGCGGTACAGGCACATCAGGGCGCGGAGAGCGTTTACGACAAGCTGAGGATGTTCAACGGACAAGCTGCTGGCTGGCCACCCGCATGGTATTCCGCAACTCCTTCCCATCATCCCCTTGCTACCGGCATTCCGACGGCAGCGACCCCAGGTTCGGGACAGAGTTTACTGCCTGGGGGGCAACTTCACGGGCGCGATGATTCCCTTCTCAAAAGGAGCGATACCGGCTCCTTGCTTTCCCATCAGCAGGAAACCACATCCGATGGTAATTCCGAACACAACTCTTCCGGTGACGAAGATTCGCAGGTTCGATTGAGGCTGAAGCGGAAACTACAGCGCAATCGGACTTCGTTTTCCAACGAGCAGATCGATAGTCTTGAGAAAGAATTCGAGCGGACACATTATCCGGACGTGTTTGCACGGGAGCGTCTCGCCGAGAAGATTGGATTGCCTGAGGCACGTATCCAGGTGAGTGTGAATGTGCGAGTGAATGTGGTGTGTTGCCTTCCACTCGTCCTCACCATTCTTAGTCCTCACTCACCATTTTTCCACTCTTTTTGCGCCTCCTACTTATCTCACTGCTGCTTCTTCCTCTTCGTCGACGGAAACCAAGCGACCGTTAAACGTGACGACGCTCCTTCATTAAGAGTCTTCACCATCTCGTCTGATCGTTCCACATAA
Protein Sequence: MPPPQEDLMHGGGAGIGGGSMVGQNSIFGCSAAGHSGVNQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVNKIADYKRECPSIFAWEIRDRLLQEGVCNNDNIPSVSSINRVLRNLASQKEQQAAVQAHQGAESVYDKLRMFNGQAAGWPPAWYSATPSHHPLATGIPTAATPGSGQSLLPGGQLHGRDDSLLKRSDTGSLLSHQQETTSDGNSEHNSSGDEDSQVRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVSVNVRVNVVCCLPLVLTILSPHSPFFHSFCASYLSHCCFFLFVDGNQATVKRDDAPSLRVFTISSDRST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01389321; iTF_01390987; iTF_01389374; iTF_00011043; iTF_00010977; iTF_00380240; iTF_00089493; iTF_00064318; iTF_00064402;
90% Identity: iTF_00881186; iTF_00881128; iTF_01389321; iTF_01390987; iTF_00064402; iTF_00064318; iTF_01389374; iTF_00011043; iTF_00010977; iTF_00089493;
80% Identity: iTF_01389374;