Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.008 29 5.2 0.1 26 48 11 33 7 37 0.87

2 9 0.0065 23 5.4 0.0 23 48 39 64 34 68 0.86

3 9 0.025 89 3.6 0.0 23 48 70 95 66 101 0.86

4 9 0.081 2.9e+02 1.9 0.0 24 44 100 120 92 128 0.79

5 9 0.0013 4.8 7.7 0.1 24 48 129 153 122 157 0.86

6 9 0.048 1.8e+02 2.6 0.0 24 49 158 183 150 188 0.82

7 9 0.22 7.8e+02 0.6 0.0 26 48 188 210 184 214 0.85

8 9 0.0061 22 5.5 0.0 23 48 216 241 210 244 0.86

9 9 0.022 80 3.7 0.0 23 45 247 269 242 272 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.008	29	5.2	0.1	26	48	11	33	7	37	0.87
2	9	0.0065	23	5.4	0.0	23	48	39	64	34	68	0.86
3	9	0.025	89	3.6	0.0	23	48	70	95	66	101	0.86
4	9	0.081	2.9e+02	1.9	0.0	24	44	100	120	92	128	0.79
5	9	0.0013	4.8	7.7	0.1	24	48	129	153	122	157	0.86
6	9	0.048	1.8e+02	2.6	0.0	24	49	158	183	150	188	0.82
7	9	0.22	7.8e+02	0.6	0.0	26	48	188	210	184	214	0.85
8	9	0.0061	22	5.5	0.0	23	48	216	241	210	244	0.86
9	9	0.022	80	3.7	0.0	23	45	247	269	242	272	0.86

Coding Sequence: ATGTCGGCTGTACATTTGGGCTCTGAGGAGGTGTGCAACATATGCAAGAAGACATTTAAATACAAGCAAGGTCTACGCAGGCACATGTTGGCTGTACATTTGGGCTCTGAGTTAAGGCCCTTTAAATGTGACATTTGCAAGAAGACATTTAAATACAAGCTAGGTCTACGCAGGCACATGTTGGCTGTACATTTGGGCTCTGAGTTAAGGCCATTTAAATGTGACATTTGCAAGAAGACATTTAAATTCAAACGGAGTTTAAGCACCCACATGTCGACTGTACATTCGAACCTTCCACCCACACATTGCGACATTTGCAAAAAAACATTTAAATACAAGAAGAATATACTCGGGCACATGTTGGCTGTACATTCGGACCTTCCACCCACTCAGTGCAACATTTGCATGAAGACATTTAAATACAAGAAGAATATACTCAGGCACATGTCGGCTGTACATTCGGACCTTCCACCCACTCAGTGCGACATTTGCAAAAAGACATTTAAATATAAACAAAGTTTAAGCAACCATATGTCGGCTGTACATTTGGGCTCTGAGGAGGTGTGCAACATATGCAAGAAGACATTTAAATACAAGTCAGGTCTACGCAGCCACATGTTGGCTGTACATTTGGGCTCTGAGTTAAGGCCCCTTAAATGTGACATTTGCAAGAAGACATTTAAATACAAGCTAGGTCTACGCAGGCACATGTTGGCTGTACATTTGGGCTCTGAGTTAAGGCCCTTTAAATGTGACATTTGCAAGAAGACATTTAAATACAAAAAGAATTTAAACATACACATGTCGGCTGTACATTAA
Protein Sequence: MSAVHLGSEEVCNICKKTFKYKQGLRRHMLAVHLGSELRPFKCDICKKTFKYKLGLRRHMLAVHLGSELRPFKCDICKKTFKFKRSLSTHMSTVHSNLPPTHCDICKKTFKYKKNILGHMLAVHSDLPPTQCNICMKTFKYKKNILRHMSAVHSDLPPTQCDICKKTFKYKQSLSNHMSAVHLGSEEVCNICKKTFKYKSGLRSHMLAVHLGSELRPLKCDICKKTFKYKLGLRRHMLAVHLGSELRPFKCDICKKTFKYKKNLNIHMSAVH

Sequence clustering based on sequence similarity using MMseqs2