Basic Information

Insect: Sylvicola fuscatus
Gene Symbol: MBD-R2
Assembly: GCA_026546915.1
Location: JANSTS010010290.1:13966-17665[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2e-18 3.5e-15 55.1 0.3 3 75 372 443 370 445 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2e-18	3.5e-15	55.1	0.3	3	75	372	443	370	445	0.90

Sequence Information

Coding Sequence: ATGAGTCCCCGCAAGTGCGCAGTGGAGGGATGCGAGTCCATCTCTGGCAAACAAGAGCATATTGGCGTCACCTTTCACATGTATCCAATGCATGCTGAGACTCGCAAGCGTTGGATCAAAAACACACGCGTCGACCGTCCAATCACCAAAAGTGTGCTAGTTTGTTCTCGCCACTTTCGCCAGACTGACTTTCAGCGCATCAAAAACAACAAATTCGTTTTGAAACAGGGCGCCACGCCGACTATATTCTTTTGGGGAATATATGACGCTAACGACGATTTAATGACGCAACAAGATGAGATTAAGACCGAACCAATGGACACGGACACACTCACACCGTGCGCGGATTTAAACAACACTTTCACTCCAGTTGCTGTCAAGGTGGAACCGTCTACATCTCCAGTGAAAAATACTTATCCATCGAGGCCTAATCCGTTCGATAATTTTGTGGCTGGTGATGCCATTGAGGCACAGGACTTTCAGCTGCAGTGGCATTCAGCTAAAGTAATTGAAGTGGACAGTGAGGAGCGTGAGGTGTTGGTTCATTTTAATGAGAATTTGGACGGTCGCGATGAGTGGATACCAATGAATTCAAGTCGACTGCGATTGCAACAAACTCCAAAGGGTTCCAAGCATTTGTTCAAATTAGGCGAGAGTGTTCTAGCCAGGTGGAATGATTCACGAAAGTTTCCTGCCACTGTACAGGGTCTAAGAGATGATGATATGTATGAAGTTCTGTTTGAAGATGGCTTTTCGAAAATTGTCAAAGGTTCTCACATTTCCAAGAGAAAATTAGTAAGCATCAGTACAACTCTGCCGTGCGCAACACCGCCAGTAGAGAAGGCCGCCGAAAAGACTGAAGAAAAACCAGAGGAAAAGCTGAAGCAAGGAAAGAAAGTTAAAAAACAGGAAACAAAGCCGAAAATTGAGCTGACTCCCGAAAAAACGACCCCACATCAAGTGAAGCAACAATCGTTTAACAAAAATCTCGACATCTCCAAAATGAATATTCCAGAGATACCGAGAGACGGGGAATGGGCGTGCCACTGGATAAATGACTGTCCCATTGGCAAGGAGAGTTTTCTAGAAGGACCTGATGGTCATCGCAAGCGCACCGTTCTCGTAGATGATTGGCGTCTGCCAGAAGGTTGGGCCAAGCACATGTACCAACGTTCTTCAATATCTGGCAAGTGGGACGTTGTGCTGGTTGGACCGACCAAAAAGAAGCGATTCCGCTCTAAAAACGACATAAAGACATGGCTGGAGGAGAATAAGCAAGCATACAGTCCAGATGTGTACGATTTCTCGATTCACAAGCGACGTGCAAAGGACTTAGGCGCCTATGTCTATACTGAAGAGTATCAAAAATATCGTCAAGAGATGGAAGTTGCACAGGCTAACACTTCAACGACTTCAGACCCAGGTGTTATCATTCTAAAAAAGGACAAGCCAGAAAAAAAGTCATCACCAGAAGTTCCACCCAAAGAGAAAAAGCCGAAAAAACCCATAAAACCGGAACCATTTGATGGCAATAAAACGGCACCAGCAGCTCTGGCAATTACGATCAAAGAAGAAGTAGTTTCTCCGACAAAGACACCTCTGATATTGCCGCCACCCGGATTCGTCTATGTGGGATCACTGTTGGTGGAAGTAAAGGATAACCTATTTAAATGTCCAGGAACCGGTTGTGAAAAGACATTCCGCAAAGAGAACATCATGCAAGTGCACGTCAAACATTACCACAAAGAATTGGCAGTTAAATTGGGTGTCTGTCCCAATATGACAGATTTGGCGTACCTACGGCAAAGTGCTTCTGAATATATTGAACCTTTTACGCCACCTTCAGCACCTTCAGTTCCTGCAAAATCTCGAAATGAGATAAATCGACGCCGGCCGTTGCAACAGTCGCGTGTGCGTAAATTAAACACATCCTTAGATGAGACCAATACAACTGCTGAAGTGTCTACCACTGAGAAAAAGGACCCTATGGATGTGTGTGAACTCCAAGGACCACCAGCCAAGATGGTAAAATTGGAATCGAAAGAGGCAAAGCCGCATGTCTTTAAGGTGCCAGTAGAAGTAGTGCCAGAAGTGCCAGTAACAACGAGCGCTTCGATTCCAGTATTACCCCAGCCGTTGCCTGCTGTCGATCGGAACAATGATTTTGAGGACCTGTTTACAAAGGGCAATGATTTCGCTTCCGAATTGATGGATGATTCAACGACAAATAACAGCCAACAGTCAAACTCCACGTCTGGCGACAACACAGCCTCGTCAAAGATGACGGATGACATCAAAATGGAAACAGAGCCTGCAACCGACGCAAATGCTTCGTCAAACTTCATCCAGGAGAACGGCAAACTAATTAAGATTGTTCGTATGCGCAAGGAGGAGATTATCAACTGTCCGTGCCAGTATCCTGAAGAGAACGGCCTGATGGTGCGATGTGACTTATGTCTGTGCTGGCAACATGGTTGGTGCTATCAGATTAACAACACCACTGAAGCACCAGAGAAGTTCATCTGTTACATTTGCAAGAATCCAGAGCGAGGTCGTAAGTCGCATCGCTACCATCACGACCAAGATTGGTTGTACGATGGCAAAATGGCGACGTCGTTCAACCAGCCTTCGTGTTTTGCAAAGGAAGTTCGCGAGCAGCAGAGGGCTGACCAGCTGAAGAAAACGCACACAATGTTCGGCAATCTGGTCGAGCTGGAGCGTTTCCTGCACTCGCTGCGCGTCAAGACTCATATCGCCGAAAATCCCAACCATCCGAAACTATATTTATGGTCAAAGGATTGGGAAGCCGAGGAAGAGGAAGATATGAAGCTGAACGAGGCGCCTTTGCTAAGTGATGATGCCAACGATCTATTCCTACCAATTCTCAACTCAATATTGCCACAAACCAGTCGTGAGCTGTACAATATGCTGACGAGTGATGATACCAAGAGCATTGACCTTGAGAATCCCAGTATTCTGGCAAATTTGCTGGCCTCGCCAGCCACGCCGCCAGCAGCTACTGTCACTTCCAAACAAATGCAGTTGGGCTCGACGGTGGCTGTCAACTTAACGGACCAGCTTATGGCCGACTGTAAGGATGAGTCTGTTGTCGATGATGTGGAGTACAATCAGCCGGGCACGTCAAAGGATGCAATCCGACGCGACCAGGAGCTGGAAGATAAACGCCGTGAGTTGGAGGAAGAGTCTAAAAGAGCCGAGGAAGAGGACAAACAACAAATGGATAAGTTTGCGATGGAGGCGGCGCGAGCCGAGGCGGATCTGTTGATACCTTGCACAGCACCAGTGCCAGAGGCAGCTATTGATCCTGTTGAGTGTCAGATTCGGCTGCTGGACCATGTTTTAGCGCAGCAGGAGAAAGTGTTGGCGCGTCTTGATTTCATTTCTGAGCAGGTTGATGGTATTTGCAATGATGAAAGCATCGACATCAATGTTATCAAAGATGATCAACTGCTAAAGCGCACAATGCAACTGCTGGTGAAAGATGTTCGTACCGTCGGTCGATATGCGGAGATCAACATGGATCCAGACGCACATCCTACTATAATTCCAAACATAAATTAG
Protein Sequence: MSPRKCAVEGCESISGKQEHIGVTFHMYPMHAETRKRWIKNTRVDRPITKSVLVCSRHFRQTDFQRIKNNKFVLKQGATPTIFFWGIYDANDDLMTQQDEIKTEPMDTDTLTPCADLNNTFTPVAVKVEPSTSPVKNTYPSRPNPFDNFVAGDAIEAQDFQLQWHSAKVIEVDSEEREVLVHFNENLDGRDEWIPMNSSRLRLQQTPKGSKHLFKLGESVLARWNDSRKFPATVQGLRDDDMYEVLFEDGFSKIVKGSHISKRKLVSISTTLPCATPPVEKAAEKTEEKPEEKLKQGKKVKKQETKPKIELTPEKTTPHQVKQQSFNKNLDISKMNIPEIPRDGEWACHWINDCPIGKESFLEGPDGHRKRTVLVDDWRLPEGWAKHMYQRSSISGKWDVVLVGPTKKKRFRSKNDIKTWLEENKQAYSPDVYDFSIHKRRAKDLGAYVYTEEYQKYRQEMEVAQANTSTTSDPGVIILKKDKPEKKSSPEVPPKEKKPKKPIKPEPFDGNKTAPAALAITIKEEVVSPTKTPLILPPPGFVYVGSLLVEVKDNLFKCPGTGCEKTFRKENIMQVHVKHYHKELAVKLGVCPNMTDLAYLRQSASEYIEPFTPPSAPSVPAKSRNEINRRRPLQQSRVRKLNTSLDETNTTAEVSTTEKKDPMDVCELQGPPAKMVKLESKEAKPHVFKVPVEVVPEVPVTTSASIPVLPQPLPAVDRNNDFEDLFTKGNDFASELMDDSTTNNSQQSNSTSGDNTASSKMTDDIKMETEPATDANASSNFIQENGKLIKIVRMRKEEIINCPCQYPEENGLMVRCDLCLCWQHGWCYQINNTTEAPEKFICYICKNPERGRKSHRYHHDQDWLYDGKMATSFNQPSCFAKEVREQQRADQLKKTHTMFGNLVELERFLHSLRVKTHIAENPNHPKLYLWSKDWEAEEEEDMKLNEAPLLSDDANDLFLPILNSILPQTSRELYNMLTSDDTKSIDLENPSILANLLASPATPPAATVTSKQMQLGSTVAVNLTDQLMADCKDESVVDDVEYNQPGTSKDAIRRDQELEDKRRELEEESKRAEEEDKQQMDKFAMEAARAEADLLIPCTAPVPEAAIDPVECQIRLLDHVLAQQEKVLARLDFISEQVDGICNDESIDINVIKDDQLLKRTMQLLVKDVRTVGRYAEINMDPDAHPTIIPNIN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01382962;
90% Identity: iTF_01382962;
80% Identity: iTF_01382962;