Basic Information

Gene Symbol
Mbd2
Assembly
GCA_026546915.1
Location
JANSTS010002600.1:22178-24518[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3e-23 5.3e-20 70.5 0.0 1 74 14 82 14 85 0.93
2 2 0.00093 1.6 8.0 0.0 28 75 317 372 301 374 0.88

Sequence Information

Coding Sequence
ATGTACAATCCCGGCGGCGGCAGCTTGAACAACATAACCATCGAGCGCAAGAAGACCGACTGCTCGGCTCTGCCCAAGGGATGGCAACGCGAGGAAGTGATGCGCAAGGCGGGACTGTCCGCTGGTAAAGTAGACGTCTACTACTACAGTCCAGCGGGTAAAAAAATCGATAGTAAGTCCCAATTAGTACGTCAGCTGGGCGACCAATTCGACATAACCGCCTTTGATTTCcaaagtggtcgctacatgcatccagcatcggcaaccgccacatcggccggccatctgtcgaacagtagccacagcggcagtcatgcggcggcggcggcggctgcacacgcccaccacaacatgatgtcaatgccgatgtcaatatcagcattgtcgtcgtcatcgcacacagccaccgcctccggtggattacatccacatcaatattcacaacaccaccatcatcagcaacagcatcaccatcagcagcagcagcagcatcaacaatcgcaccatcaacagcaccatcaccaccaccaacagcaacagcagcaccatcatcaacaacagcaccagagatcggcgctgcctcaatccatgcaggtgtcatctaattcgtacaaacgctcactgccgtcagccatgcagggaatgcaccatcacggcagcaccagcacagcgacactgtccagcatcacgcaacagctgcagcaacagggctgcgccggcattggcctagccagcaacggcacgtccataacaatggcgccaccggcaccagtggcgccgttggcctccggctcctcgtcctcactggcgtctgccactattatcagTTCACAGACGCAGTCTTCTAGCGGCGGAAGTGGTGTTAGTGGCGGTGGCAGTGGTTCGAATTCGTTATTCGCTCTGCCGGCGGCGCCTTCAAATCGTCACCATCCGTACGAGTTTAGTCGCAACATGCGCGCTGATGTCACATTGGTGCCGCCAATCCGTCAGACGGCGTCCATCTTCAAGCAACCAGTCACCGTATACAAGACACAGGAAGGCAAAGTGAAGCACGAACTGAAGCACGGTGTCCAGGAGAAGCCGAAACAGTTGTTCTGGGAGAAGCGACTGGAGCGCATGAATGCGTGCGACTCCGGCGGCCACGAATTCAGCGCCATCGATCTGCCGAAAGTGTTGCGTCCCATCGGCCCCAATGTTGACGAGGGCACACTGCTGAAGTCCATAGCGACAGCGCTGCACGTGTCGACGCAGCCTGTCACCGGCCAAATGGACGGCCGTCCGCCGATCCTGACGAACGCCAGTGTTTGTGTGAATCCAGAGCAGCCGCTCATGTTGGCTGTGAATATCAATGAGGATGATATACGTCGCCAGGAAGATCGTGTGCGATCGGCCAGATCAAAGTTGCAGGATGCACTCAAAGTTTAA
Protein Sequence
MYNPGGGSLNNITIERKKTDCSALPKGWQREEVMRKAGLSAGKVDVYYYSPAGKKIDSKSQLVRQLGDQFDITAFDFQSGRYMHPASATATSAGHLSNSSHSGSHAAAAAAAHAHHNMMSMPMSISALSSSSHTATASGGLHPHQYSQHHHHQQQHHHQQQQQHQQSHHQQHHHHHQQQQQHHHQQQHQRSALPQSMQVSSNSYKRSLPSAMQGMHHHGSTSTATLSSITQQLQQQGCAGIGLASNGTSITMAPPAPVAPLASGSSSSLASATIISSQTQSSSGGSGVSGGGSGSNSLFALPAAPSNRHHPYEFSRNMRADVTLVPPIRQTASIFKQPVTVYKTQEGKVKHELKHGVQEKPKQLFWEKRLERMNACDSGGHEFSAIDLPKVLRPIGPNVDEGTLLKSIATALHVSTQPVTGQMDGRPPILTNASVCVNPEQPLMLAVNINEDDIRRQEDRVRSARSKLQDALKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-