Basic Information

Gene Symbol
Aef1
Assembly
GCA_963854165.1
Location
OY974084.1:6851580-6851987[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.015 77 3.3 0.0 22 47 7 32 4 37 0.82
2 4 1.5e-05 0.075 12.9 0.0 21 52 34 65 32 66 0.88
3 4 0.016 81 3.2 0.1 21 44 62 85 60 90 0.86
4 4 4.2e-05 0.21 11.5 0.1 21 46 90 115 85 124 0.87

Sequence Information

Coding Sequence
ATGACGATAACCAAGCTAGATAAACCGTTTCATTGCTCCGTATGTGACAAGGAATTTCGCCAATTGAGCACCCTGTCGAATCACCAAAAAATTCACACTGGCGAGAAACCGTACAAATGTGACATATGTGATAAGTACTTTCGACAATCCAGTACCCTTACAAATCATGTGAAAATTCACACTGGCGAAAAGCCATTCAGTTGCAATTGTTGTGGCAAACAATTTCGACAATTGAGCACACTCACCAATCATCAAAAGATTCACACGGGTGAGAAACCGTTTGAGTGTGCCGTgtgcaaaaaacaatttcgacAATCCAGCACCTTGAATAATCACATTAAGATCCATGTCGGTGACAAACATTTTCTGCAGGAGTTGCAGCAGGAATTGAAGCAGGAAAACACATGA
Protein Sequence
MTITKLDKPFHCSVCDKEFRQLSTLSNHQKIHTGEKPYKCDICDKYFRQSSTLTNHVKIHTGEKPFSCNCCGKQFRQLSTLTNHQKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVGDKHFLQELQQELKQENT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01164355;
90% Identity
iTF_01382420;
80% Identity
iTF_01382420;