Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.6e-24 1e-21 76.9 0.0 3 107 38 141 36 144 0.93

2 3 7.3 9.7e+02 -0.3 0.1 77 108 143 174 142 176 0.85

3 3 1.9 2.5e+02 1.6 0.2 37 69 168 198 163 209 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.6e-24	1e-21	76.9	0.0	3	107	38	141	36	144	0.93
2	3	7.3	9.7e+02	-0.3	0.1	77	108	143	174	142	176	0.85
3	3	1.9	2.5e+02	1.6	0.2	37	69	168	198	163	209	0.86

Coding Sequence: ATGaaccaaattcaattcaaaacaacCCCAAAGCTTGTTGAAGAGGATGGTGTTAAAGTGGGCACTTTTGCTATTGCCCATCAAGGTGATGAAGATCTGGCGAAAATGTATAGTTTCCAGAAGAACGGAGAATTTTGTGACGCATGTCTGATTGCGGAGTCCGGCAATACCAAAATTTTCGCCCACATACTTGTTTTATCAGTAGCCAGTGAATATTTTCGCGGCTTGTTTAAACCAAATAAAGAAGAATTCAAATTTGTGGTTCCCCTCAGGGGTGTGCCCGGCAAAGtacttttgaaaattgttgattttatcTACACTGgAGAAATTAAGCTTACAGAGGGGAATGTCGAGGAATTTCTTAAGTGGTCAAATGTTTACCGATTGCAGAACCTGGCTGCAGTTTGCGAGAAGTTTCTAATCCTAAACATAAATTCGACAAACTTaatgaaataccaaaaactAGCCTCAATCTACAAATGTGGGCTTTTGAAAGAagaatttcacaaattatttgaCGAGAACTTTATGGATTATCATCAAACGGAAATGCTTCAATTGACTAGCGTTGACGATTTGAAGCAAATTCTATCACGAGACTCTCTGCAGTGCGACTCtgaagaaaatatttgtaatgcaGTAGCTCATTGGTTGAAGTTCAATCCCAGCGAAAGGGAACAACAACTCATGGAATTGGTTCGATGCATCAGATTTCCAATGCTGGCTCCAAGTTTCATTCTTAAACGCGTGGACGATTTTAAAGGTTGTGGTGAGGCTGCACTGCACTGCATTAAGGCATTGCAATGGCACACTTTAAATGAGGAGGAGAAAGCATTGGGGGAGTTTTGTACCACCCCAAGACGCTCCAATATATCTACTGCTTTCCAACCTTTAGTCTTTTATGAAAATGGGGTTTTCACTTATGATGATTGGGAGGACATAATGCATCAAGCAGCTTGTGTGACGTTGAGAAGTTTGACATCAACACCGGCGAGTGGTCGACGATGGCTCCTCTTTTACACGCTAGAAGATCATCACggtgtttaa
Protein Sequence: MNQIQFKTTPKLVEEDGVKVGTFAIAHQGDEDLAKMYSFQKNGEFCDACLIAESGNTKIFAHILVLSVASEYFRGLFKPNKEEFKFVVPLRGVPGKVLLKIVDFIYTGEIKLTEGNVEEFLKWSNVYRLQNLAAVCEKFLILNINSTNLMKYQKLASIYKCGLLKEEFHKLFDENFMDYHQTEMLQLTSVDDLKQILSRDSLQCDSEENICNAVAHWLKFNPSEREQQLMELVRCIRFPMLAPSFILKRVDDFKGCGEAALHCIKALQWHTLNEEEKALGEFCTTPRRSNISTAFQPLVFYENGVFTYDDWEDIMHQAACVTLRSLTSTPASGRRWLLFYTLEDHHGV

Sequence clustering based on sequence similarity using MMseqs2