Basic Information

Insect: Sturmia bella
Gene Symbol: MBD-R2
Assembly: GCA_963662145.1
Location: OY759168.1:97691690-97701238[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.7 1.5e+04 -3.9 0.0 42 57 90 105 68 112 0.77

2 3 2.1e-22 8.4e-19 67.4 0.1 4 76 419 489 416 490 0.93

3 3 2.2 8.7e+03 -3.2 0.0 45 63 925 941 924 946 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.7	1.5e+04	-3.9	0.0	42	57	90	105	68	112	0.77
2	3	2.1e-22	8.4e-19	67.4	0.1	4	76	419	489	416	490	0.93
3	3	2.2	8.7e+03	-3.2	0.0	45	63	925	941	924	946	0.79

Sequence Information

Coding Sequence: ATGGGACGCCGGTGTTGTATAGCCGGTTGCATGTCAACTTCACGCTTGCCCGAACACCATGGTGTTACATACCATTCCTTTCCCGCTGACCAGAATTCGCGGTCTATATGGAtacgaaatacaaaaataagttcCGATCGACATATAACTAAAAGTGTTTTGGTATGCTCTAGACACTTTCGTCGTGCTGACTTCCAGCCACAACGTAGCGGAAAATACttgctaaaacaaaaagtgtttcCCACTGTGTTCCCGTGGGGCAAAATTGATGCATCTCAAATTGAAGAagatttagaatttttaaattcgACCAGTGTGGCACAACCTAGCAATTTGCTGACCACTTCTACGACCGTGGATGAGGACACAAAAGCCACTGTTGCTGCCACAGTAGCACAAATAATGGCCCAAACAGCGGAGCTAAATGCAGCTGCTGGCATAAAAGTAGAGAAACTAGACGGAAGTCTTGAAGAACCCTTAAATGATAGTGCAATTGCGGCTACACCGCCAAATGTTAAATTTGAGCCTGTTACATCATTCAATCCCGGAGCACGCTTGGAGGCCCAAGATTTCGATGGTGTATGGCATGCAGCCCGTATTGTGGAGGTTGACAATGATGACCGGGAGGttcttattaaatttgaaaaaaatgccaAACATAAATCCAGTGTTGCCGGTACAGAGGAATGGATACCAATGAATTCGTCCCGTTTGCGGCAACGCATTTCCACAAAGCCGATATTAAACTTTGAACTTGAAGAAAAATGCTTAGCCCGATGGTCGGGACCTCGTAAATTTCCCGGTACAGTTAAAAAAATTCTGCCAAATGATGTCtatgaaatattatttgatgATGGTTATGTTAAAAATGTGCGTGCTATTCATATGAATAAAATACAGCCTACGGCAATCGTGAAACCAGAAGCTGTGGAAAAAGCAGCAGTAGAGGGATCCGCAATTATACCCGATGTTCCTGCAAACAGTGACTCAAATTTGGTTACTCTCCATGCAACGCCAACGAGCTCAGCAGTGAAGAGACCATCGTCCGGTCAGCACTCAAGCTGTCCATCAAAAAAACGTGCGCACAATGGCCCAAGAAAGGATTGGCCGTTGTTGGACTTATCTAAATTGGATTTCTCTTCCCTGAATTTACCGGAAATTCCCAAAGACGGCGAGTGGACTTGCCACTGGGTGAATGATCAGCCCATAGGGCGTGAAGGGTATTTAGTTGTTGGGGAACATCGTAAGCCCACAGTGATAGTTGAAGATTGGCGTCTGCCTCCTGGCTGGATCAAGCATATGTATCAGCGTTCCAATGTTTTGGGAAAGTGGGATGTAATTTTAGTAACCCCAAATGGTAAACGTTTCAGATCTAAAGCAGACCTTAAGACCTACCTGGAAGAGCTGGGACAAGTTTACAATCCTGACATTTACGACTTTAGCATACATCGTCGTAGAGCCAAAGATATAAACTGTTATGTACATACTCCTGACTATGTACCGCAACAACCGGTCAAACCAAAAACGTCCCTAAACACAACCCTGGACAGCAGTGTGGAAGATAAACCTTCATCGCTGGTGGGAAGCTTGGCGACAGCTGTGTCCTCGCCCTACATGGACACTCCAATTGCAGAAGCTTTACCACCCATAGAGCTGCTAACGTCGTCTAGCAGTTTGGCGGCAGAGGATAAGAGCGTGACACAAGTGGAGGCTGAAGTACCAAAACAGCTTCTTGAGGCTGCAGAAATCAGTTCTACACCAACTCCTACTTCAACTCCTACAGTTGGTCTAAAAGAAGAAGCGGTAGTATCTTCAGACAGTGCAACGCCTACACCTATTTTACCGCGAACGGCAACGCCAGCAAAGAATTTAGAAGAAAGCCAACAAGTTGATGAGGGCTATGCTCTGATTGGTGGCCTAAAAGTGCAAATCATTGATAATCTATTTCGTTGTCCTCAAGAGGGTTGTTGCAAAAACTTCCGAAAAGAAAACCATTTGCAGATTCATGTGAAACACTATCACCGAAACCTAGTCAAgctATTAGGTTCCTGCCCTAAAATGTTGGAACTGGCAGAAAAACGTACACATCCCGTCGATAACGATGTGATTGAACCCGTGCCCAAAAATCAAATTCCCAATCAACAGTTCTTTGCCAAATTACATCAACAAGATCTTGAACAAACTAGAGCACATCGCAGGAGTACTGGTGTTCCGAAGGGCAGTGTTGAAACACCTCCCGCAACAGAAATGAAATCAGAACAGATTGATGAGGCGCCCATTAAAGCTGAGGAAACCTCACAAAATATGGAGAATTCGCAAAATGATATTTCCTTAAATAATACAACGGCTACTTCAAGTGTTTTAATGGAGAGCTCATTTGCCTCCACCAGTGCAGCAGATGATTCGTTAGTGGGTTTGAAACAACCTGCAGTCATTAAAAGATCTAGATTTTCGCCCAATAGGAAAACATCTGGATCGAGAAAAAGTAACCGTCAAAGAACTACTAGAAAATATCTGACCGCAGCCCAGGCCACAGCGGGTGTGGTGGCCTCTTCAACTTCTTTGCCGTTGGTTACCGATACCAGCTTCAGCAGTGTGGCTGAGTTTGAAGAGACACGTCACTCATTCAATGGCACACCAGATATTAACAAAGAcgcaaaaaaacgtaaaactGTTTTAGCCTCCAATACCCCTCTCAGCAGCGTTGATTCTCCCATTACGGCCGACTCAGGTTCGAACTCCTTCCAACCACAAAATTCCACAGAAAACGATACCATCAACCAACCTCCCCAATATATCAAGGAGAATGGTGAACTAATTAAGATAGTGCACATGCGTCAGGAggaaattattaattgtttatgcGGCTACTGCGAAGAAGATGGTTTAATGATACAATGTGAGCTTTGTCTGTGTTGGCAGCATGGCCTGTGCAATGGCATAGATAAAGTCTCTCAGGTACCAGACaagtatgtttgttttatttgtcgtAATCCTCAGAGAGTACGTGAATCGTTACGTTTCAAACACGACCAAGATTGGCTATATGAAGGCAAATTGCCTGTAGCTAACTACCATACTTCAAATACCACTCAGCTGAATAAAAGATCAGAATACCTGAAAAGGTCTCACATTTTGACTGGCAATCTATTGGAGTTAAAGAACTACATGCACTCGTTgagagttaaaattaatatagcCAATAATAAATGTCACCCCAAACTTTATCTCTGGGCTAAAAAGTGGGATGAGGACATAGTCACTGATGTAAAGAATGAAGTCAAGCCTGACATTGGGGAAGACCACAAAGCAACAGATGCCAATTTGTCTGCTACACctacaaagaaaattaaatctgAACCCACAACACCAGCAAGACTTGTGCCAAACATACCACAACCCGAAGCTCCCATTGATCCCGTTGAATGTCAACAGCGCTTACTGGAACATATTAAAATACAACAAGATCTGGTCATGGGGCGTTTAGATGACATTGAATCAGTCATAAACGctttGGAAAACGAGGATGATTTGCCGGATTTACGTGAAGAAGACTTCGGAAGCACTAAAGATGCTGTCGCCATTTTTATCAAAGAATTGGATACTGTCAAACAAATTGCCAAACTCAACAGCTTAGAACACACCAAATTGGCATACAAAAATCCCATTCCTCCCATTAAGTAG
Protein Sequence: MGRRCCIAGCMSTSRLPEHHGVTYHSFPADQNSRSIWIRNTKISSDRHITKSVLVCSRHFRRADFQPQRSGKYLLKQKVFPTVFPWGKIDASQIEEDLEFLNSTSVAQPSNLLTTSTTVDEDTKATVAATVAQIMAQTAELNAAAGIKVEKLDGSLEEPLNDSAIAATPPNVKFEPVTSFNPGARLEAQDFDGVWHAARIVEVDNDDREVLIKFEKNAKHKSSVAGTEEWIPMNSSRLRQRISTKPILNFELEEKCLARWSGPRKFPGTVKKILPNDVYEILFDDGYVKNVRAIHMNKIQPTAIVKPEAVEKAAVEGSAIIPDVPANSDSNLVTLHATPTSSAVKRPSSGQHSSCPSKKRAHNGPRKDWPLLDLSKLDFSSLNLPEIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVIVEDWRLPPGWIKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEELGQVYNPDIYDFSIHRRRAKDINCYVHTPDYVPQQPVKPKTSLNTTLDSSVEDKPSSLVGSLATAVSSPYMDTPIAEALPPIELLTSSSSLAAEDKSVTQVEAEVPKQLLEAAEISSTPTPTSTPTVGLKEEAVVSSDSATPTPILPRTATPAKNLEESQQVDEGYALIGGLKVQIIDNLFRCPQEGCCKNFRKENHLQIHVKHYHRNLVKLLGSCPKMLELAEKRTHPVDNDVIEPVPKNQIPNQQFFAKLHQQDLEQTRAHRRSTGVPKGSVETPPATEMKSEQIDEAPIKAEETSQNMENSQNDISLNNTTATSSVLMESSFASTSAADDSLVGLKQPAVIKRSRFSPNRKTSGSRKSNRQRTTRKYLTAAQATAGVVASSTSLPLVTDTSFSSVAEFEETRHSFNGTPDINKDAKKRKTVLASNTPLSSVDSPITADSGSNSFQPQNSTENDTINQPPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMIQCELCLCWQHGLCNGIDKVSQVPDKYVCFICRNPQRVRESLRFKHDQDWLYEGKLPVANYHTSNTTQLNKRSEYLKRSHILTGNLLELKNYMHSLRVKINIANNKCHPKLYLWAKKWDEDIVTDVKNEVKPDIGEDHKATDANLSATPTKKIKSEPTTPARLVPNIPQPEAPIDPVECQQRLLEHIKIQQDLVMGRLDDIESVINALENEDDLPDLREEDFGSTKDAVAIFIKELDTVKQIAKLNSLEHTKLAYKNPIPPIK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01174299;
90% Identity: iTF_01376681;
80% Identity: iTF_01376681;