Basic Information

Insect: Stratiomys singularior
Gene Symbol: MBD-R2
Assembly: GCA_954870665.1
Location: OX940878.1:152139624-152145143[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.9e-18 4.1e-14 53.1 0.1 4 76 399 469 396 470 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.9e-18	4.1e-14	53.1	0.1	4	76	399	469	396	470	0.92

Sequence Information

Coding Sequence: ATGACGCGTCGTTGCATAATTGAAGGCTGTACGTCAAAGTCGGGCAATCCACAACATCGCGGCGTCACCTTTCATTCGTTCCCATTCGACTCGAAAACGCGTGAACTTTGGCTGCTTAACTGTCGCATCAATCCCGAGAAAAACATAACAAAGAGTGTGTTGGTTTGTTCGCGTCATTTTCGTCGTGCAGACTTTCAGCCTGCCAAATCCAACAAATACCTTCTGAGGCAAGGTTCCGTGCCCACGATATTTCCCTGGGGCAAATTAGCACCGCCTCAAACTCAATCACTGGACGATTCCAGTTCGACTGTTGTACTGAAAAACGAAATGGACTCCACCTCCGACACGAATAAAGATACGGCGAGTGACGGAACAAGTGAGGAAACAGAAAAGCCTCTAACAAAACGAATGTCGGAGGATGTAGTTCTCGGGCCTGACGCAAAAATTCCGAAATTGGGCGGTGCTCTTTCCTCGACACCAGCTTCTGATCTGCAAAGCCTTGTTCCCATGGGAACGATACCTGTTGCGGCCGGTGCCCGCAAGACGGACACTGTTTCTGGCTTTGTACCAGGCGTTCGTCTCGAAGCGCAGGATTTTGATGGAAATTGGCATACGGCTAGAATTGTCGAAGTGGACAACGATGAACGGGAAGTGTTGATCCGATTTGAAAAGAGTGGGAAATCTAAGGGCGTAAGTGGTGCAGAGGAATGGATCCCTATGAACAGTAGCAGGTTGAGACAAAAGGCTGCTGCCGCTAGTAAGTTGCCAAATGTGTTTGCGCTGGGAGAGAAATGTTTGGCTCGATGGAGTGGCGCTCGACGATTCCCTGCAACTGTCCAAAAAGTTCTCGAGAATGATATGTACGAAATCTTGTTTGATGATGGTTACATGAAAGTTCTTAAAAGTACGCATATAAGCAAACTTAAATTACCTGCTGCGAAATCCCAGCCGACCCCAGCTGCACCAAGCCCCGCACCACAGAAACTCACTGCAACCCCGGTAACTGAGAAACCTAAACCCAAAACACAACAAACCAAAAATGATTGGCCTCTAATTTCCATGAGCTCTCTAAACCTCGATGAACTGAATTTGCCCGAAATTCCGAAGGATGGAGAGTGGTGTTGTCATTGGGTCAACGATCAGCCAATAGGACGTGAAGGATTCCTCACCGTCGGTGACCATAAAAAACCAACAGTTGTTGTAGAAGATTGGCGTCTTCCTCCAGGCTGGACCAAACATATGTATCAGCGCTCGAACGTTCTTGGAAAATGGGATGTCATCCTGGTGAATTCGAACGGAAAGAGGTTCCGTTCTAAAGCTGACTTGAAACAATACATCGAAGATTTGGGGCAACATTATAATCCGGATGTGTACGACTTCAGCATACATCGACGACGAGCCAAAGACATCGGAGCGTACGTTTACACCAAAGACTACAAACCTCCGCAGCCAGTGAAACCACCACCTCCCCCACTTGAGCCCCTGCCTCCGTTACAACCACAAAACCTACTGCAAAACGCATCCCAATCCGCGATCGACCCTCTACCCTCAGGTTCCTCGCCATCATTGGGCGAATCGACCCCGATAAAGGGATTCGACGATGAAGCAGCACCCGTGGAGGATGGTTATGTATTTGTCGGCTCGTTGAAAGTGCAGATCGTAGATAATTTATTCCGTTGCCCGAAAGAAGCTTGCAATAAAAACTTTCGGAAAGAAAATCATCTACAAATACACATTAAGCATTATCACGACGACATTGCAAAACTTTTGGGTGATTGTCCGAACATGCAAGAGCTCGCTTGCAAGCGTACGATTGGCCATCCGCCAGACGAACCATTGCCTAAAAACTATCTTCCAAACTCGCAATATTTCGCAAAACTCCACCAACAAGATATACAGAATCGAATGCATCGGAAATCCACTTCGACGCCTCTCACACCTACGATTTCGACACCTTCTCGCAATGAAAATTTGGAATACACTTTACCTTCCGATCTGGACGACACCGCAAAGCTGACTGACACAACTGTGTTGGACTCAACACTTGGAACTAATCTTGTCACGGAAAGCGCTTTAGAATCAAGTTCTGCCTTCGTTCATGCGACTGGCGATGAAACTGCAGAGTCCGTAGTTGATGAGGTTAAATCCACTCCGCAGCAGGTTCCGCATGCACATCAAGCTCATCCTAAATCTGGTTCTCGCAAAAGTGGCGAACGGAAGAGCTCCAGACAGCGACTTCAAAAAAGATATCCAACCGCTAGCACGTCGACAGTGTACGACAATTCTTTCCAACTTGCCGATTTTGAAGACACAAGACATTCTTTTAATGGCACTCCCGAACAAAGGGTTTCGAAAAAGCCCAAACTCTCACATCCCACGTTCGTACAAGATACCAATGTAGATGGCAACACAACTGGAAGTGTGCCAGAACAGGCTCCACCGGCTCCAAGTCCCAAATACATCCAAGAAAATGGTGAAGTCATCAAAATTGTTCGTATGCGGTCAGAAGAAATAATCAACTGTATTTGTTCGTTTGGAGAGGAGGATGGTCTTATGATTCAATGTGAACTATGTTTGTGCTGGCAGCACGGAATCTGCAATGGCATTGAGAAGGAAAGTCAAGTCCccgaaaaatatgtttgttacATTTGTAAGAATCCAACGTTGGGACGAAACAGCATGAAGTATATTCACGATCAGGATTGGCTTTATGATGGAAAATTGCCGACTGGAAATTACCACTCGGCGAATCCGAAATTACAGGAtcgtttcaacattttaagGACAAGCCATACGCTTACGGGCAATTTGATAGAGCTCAAACGTTTTCTTCATAGTCTTCGCGTTAAAATAAACATAGCTGAAAATAAAGATCATCCGAAAATGTACTTGTGGGCAAAAAAATGGGAGACATCACCCACACGAGCCGTCGAAGCcaaagttgaaaaaactgaaaccgATGAAATGGAGAACTCGGGAGGAATAAGCGAAATCGATATTAAAGGAGAAACTGATGTTAAAATGGAGGCTAATGATAATGACCTGTCAGAACTTGTCAAACCGGAAGGTGTTGCTGTTAAACAGGAATCGCCGACAAAGCCAAAGCAAGAAATAATTGTTCCTCAGCCCAATATCCCGCAACCTGAAGCAGCAATTGATTCAGTAGAATGTCAACATCGATTACTAGAACACATTCAGAAGCAACAGTCGTTGGTAGTCGAACGTCTACAAGATATTGAATCCGATATTGGTGAACTGGAATCACTTGATCCGTGCAGCGATTTAGATAGCGATGACTTCAATCGTACAAAACAAACATTGGCGATATTAATCAAAGATTTGgaaattatgcaaaatattgCCAAAATCAATAATGTCTCATCGCCTAGTTATGTTAGTTTTGCATAA
Protein Sequence: MTRRCIIEGCTSKSGNPQHRGVTFHSFPFDSKTRELWLLNCRINPEKNITKSVLVCSRHFRRADFQPAKSNKYLLRQGSVPTIFPWGKLAPPQTQSLDDSSSTVVLKNEMDSTSDTNKDTASDGTSEETEKPLTKRMSEDVVLGPDAKIPKLGGALSSTPASDLQSLVPMGTIPVAAGARKTDTVSGFVPGVRLEAQDFDGNWHTARIVEVDNDEREVLIRFEKSGKSKGVSGAEEWIPMNSSRLRQKAAAASKLPNVFALGEKCLARWSGARRFPATVQKVLENDMYEILFDDGYMKVLKSTHISKLKLPAAKSQPTPAAPSPAPQKLTATPVTEKPKPKTQQTKNDWPLISMSSLNLDELNLPEIPKDGEWCCHWVNDQPIGREGFLTVGDHKKPTVVVEDWRLPPGWTKHMYQRSNVLGKWDVILVNSNGKRFRSKADLKQYIEDLGQHYNPDVYDFSIHRRRAKDIGAYVYTKDYKPPQPVKPPPPPLEPLPPLQPQNLLQNASQSAIDPLPSGSSPSLGESTPIKGFDDEAAPVEDGYVFVGSLKVQIVDNLFRCPKEACNKNFRKENHLQIHIKHYHDDIAKLLGDCPNMQELACKRTIGHPPDEPLPKNYLPNSQYFAKLHQQDIQNRMHRKSTSTPLTPTISTPSRNENLEYTLPSDLDDTAKLTDTTVLDSTLGTNLVTESALESSSAFVHATGDETAESVVDEVKSTPQQVPHAHQAHPKSGSRKSGERKSSRQRLQKRYPTASTSTVYDNSFQLADFEDTRHSFNGTPEQRVSKKPKLSHPTFVQDTNVDGNTTGSVPEQAPPAPSPKYIQENGEVIKIVRMRSEEIINCICSFGEEDGLMIQCELCLCWQHGICNGIEKESQVPEKYVCYICKNPTLGRNSMKYIHDQDWLYDGKLPTGNYHSANPKLQDRFNILRTSHTLTGNLIELKRFLHSLRVKINIAENKDHPKMYLWAKKWETSPTRAVEAKVEKTETDEMENSGGISEIDIKGETDVKMEANDNDLSELVKPEGVAVKQESPTKPKQEIIVPQPNIPQPEAAIDSVECQHRLLEHIQKQQSLVVERLQDIESDIGELESLDPCSDLDSDDFNRTKQTLAILIKDLEIMQNIAKINNVSSPSYVSFA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01088391;
90% Identity: iTF_01375874;
80% Identity: iTF_01375874;