Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.1 4e+04 -2.2 0.1 56 66 14 24 12 27 0.67

2 4 1.6 3.1e+04 -1.8 0.4 59 63 72 76 68 77 0.70

3 4 7.2 1.4e+05 -3.9 0.7 3 9 125 131 122 141 0.70

4 4 1.8e-13 3.4e-09 39.7 1.1 4 70 166 232 163 232 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.1	4e+04	-2.2	0.1	56	66	14	24	12	27	0.67
2	4	1.6	3.1e+04	-1.8	0.4	59	63	72	76	68	77	0.70
3	4	7.2	1.4e+05	-3.9	0.7	3	9	125	131	122	141	0.70
4	4	1.8e-13	3.4e-09	39.7	1.1	4	70	166	232	163	232	0.91

Coding Sequence: ATGATAGCATTGGCTATAGAAACAAGAAAGCTGGTTGCTCAGTACCGATGCTTGGCGTGCGGAGACATCCTCAGGAACTCCCAGGAGGACACCCTTATTAATCACTTACGCACATACCACCCTTTCATCAATATTAAAGACCACTTCGCTCCTCAGCATCGTCGACAGCAACACTACATTCCTTGTCCGTTGCCAAATTCACCGGTCAAAGGCTGTCCACAGTGTGGTCCACCACCACCACCTCCGCCGCCGCCGCATCCACCATGCCCACCACCGTTGAAACCAGCTGGACCCGTTTGTGGACCATGTGGCCCTTGTCCCCCACAACCGAACCCTCCAATTCCTCAAAACCCACCTGTCCCATGCCCTGTCCCGTATGCAGTTAACTGTCCACCTCCTACTGAGGAGGAATACTGCAGAGCCATGCAAAGACAGCAGCGCAAATTAAACCGCACCAACTACAAATTCACAGTTGAGTCGTGGAAATCTGGAGCGACCAAAGTAGTGTGTCCTTGCTGTGGCAGTGAAGAACAGCCAATGATACGACGTCAGCGCAATGAAGTGTCAGACAGCCTTCTAAGGACAATTGTTTCGTTTATATGTTGGCCTTTTAAAGTGTTACCTTTCATGCTGTGGGAAAGCAACGTTGTCAACCTGTATTGTGGCCAGTGCAACAACTTTTTGGGCACTTACAACCGTAAACTGGGATGTATCGTTGATATCGGAGCAAATCTCTGCAATCCTAGTTATTAG
Protein Sequence: MIALAIETRKLVAQYRCLACGDILRNSQEDTLINHLRTYHPFINIKDHFAPQHRRQQHYIPCPLPNSPVKGCPQCGPPPPPPPPPHPPCPPPLKPAGPVCGPCGPCPPQPNPPIPQNPPVPCPVPYAVNCPPPTEEEYCRAMQRQQRKLNRTNYKFTVESWKSGATKVVCPCCGSEEQPMIRRQRNEVSDSLLRTIVSFICWPFKVLPFMLWESNVVNLYCGQCNNFLGTYNRKLGCIVDIGANLCNPSY

Sequence clustering based on sequence similarity using MMseqs2