Basic Information

Gene Symbol
MBD2
Assembly
GCA_035578905.1
Location
JAQJVL010000009.1:4466527-4468371[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 9e-12 3.3e-08 36.0 0.1 10 67 9 64 5 92 0.89

Sequence Information

Coding Sequence
ATGACTGGACTAACAAATAATAAGGATCTGCCTAAAGGATGGAAGAAAAAAGAGGTAGTGAGGAAAACAGGAATAACTGCTGGGAGGATAGACACACAGATTATGTCTCCTGGGGGCACTATATTCCGCTCAAAAAAGTCACTATCAGAGTATTTAGTGAAAAGAAATCTACCTTACAACGTCAATGACTTTTATATAGGAGACAATCAAGAAAAAAAAAGTACAGTGGTCAATGAATGTAGGCCTTGCTCCTCACTCACAGTAAAAGAAACCCGACTCCCTCAATTAACATCTCCTAGTAATCTGGATATCACACTTTCTTCGCCTACCATAGCCTCCACTCGGCCCAGTACCACACAAAATATTCCAGTTCACTCTACACCGCAAAATTCAATTAATGCAGACTGTCCAAAATCTTCAACCTCAATAGAATTGGAACATGAAAACTCAAATTTGAAGATTGAAATTGAAGAGATCCGTAAGCAATTAAGAGATGTGACGGACCATGCAATTGAAAACGACGCCCGGCTTCTTCAATATACAGATCAGATTTTTACCATGCAAAATGGGAGCACTGACAACTCGATACAACAAAAGTCACTGGAAATAGAAttggaaagtaaaaaaataatagaacttGAAAAACTGTTGAAAACAACTCAGGACCGAGCAGAACGATTAGAAGAAGAGGTAGCTATGTTAAAACAACCATGTAAGAACTGCAGCATTCTTAAAGAGGAGACGGACAAAATGATAAATTCCATACGATGCTTGGAGGAACAAATCAAACACCTAGAGGCCTCCCATCAAGAATCCCCTTCTACCTTAAGCTCGCCTCCTTCTCAAGAAATATATCAACAGAACTCATTCAACCCTCTACTTCAACTAAGTCCTACTGATGAAGAAGATACCGACTTTACTGAGGTGAGAAGGAAGAAGAGGAGAAGGCAAAAGAAGAAGCAGAAAATGCAGCTACCAGAAAAACCAATTAAGACAAAATCAAAAGTCAATATCCCCCATCCAGCGGAACAAAACACCCCTCCAAAAAAAATTAAGCTTACGGCAAGCAACATCAACATCTGGGGAGATAGTCACGCACGTCATCTAGCTAGTATGGTTGGAGGACTTTTAGAGCCTGGTACAACGGTTAGTGGGACATGCAAGCCAGGGGCCCGTCTGGTGGATATTGCTCCCTCCCCCAACACCAACCTAGCAGCTGATCTACACGTTTTGATTGCAGGCGCCAATGACGTTGCATCAGGAATGGCTGGAAACATCTACAAGCACCTGGAGCCCACAATCCAAAACCTGCTAACGTCCAGCAAGGTTATAGTATCAACTTTGCCTTTACGGTATGATGTTGCTCCTAACAGTCCTATAAACCATTCCATTCGTCTTATAAACCACTATATAGCTGAACTTTGCTGCCGTTACAAAGGTGTGGGTCTGGTTGATGTAAGGGGCATAAGACGTAAAGATTTCACCTCCCATGGCATGCACCTTCGACATACTGGAAAAGAGATATGGGCTCGTCTCATTATTGACCAGGCTGCCAAGCTTCTGCACAAGACACCAGTAAAGCAGACGCCCCCCTCTTATCCGGACCTCAACCAGGCAGTACTAATCCGGACTGATGAGGGGACTTCTTCAGGCTGTACTCCAAGGACTCTGCCCTATGCCAACTTCGCAGAGGCACTGAAGAAACATCCCAACTGCAGAGACCAAGAGAACGACAAGGCAGTTCCAAGCAAAGACAGTCCCAAGAATGGAAACACTGCCTTTTATTGTGATGACAAAAGGGTTCATTTTTTGGACCAGCCAGCTCTAGCCGACAGTCAAAGGTAA
Protein Sequence
MTGLTNNKDLPKGWKKKEVVRKTGITAGRIDTQIMSPGGTIFRSKKSLSEYLVKRNLPYNVNDFYIGDNQEKKSTVVNECRPCSSLTVKETRLPQLTSPSNLDITLSSPTIASTRPSTTQNIPVHSTPQNSINADCPKSSTSIELEHENSNLKIEIEEIRKQLRDVTDHAIENDARLLQYTDQIFTMQNGSTDNSIQQKSLEIELESKKIIELEKLLKTTQDRAERLEEEVAMLKQPCKNCSILKEETDKMINSIRCLEEQIKHLEASHQESPSTLSSPPSQEIYQQNSFNPLLQLSPTDEEDTDFTEVRRKKRRRQKKKQKMQLPEKPIKTKSKVNIPHPAEQNTPPKKIKLTASNINIWGDSHARHLASMVGGLLEPGTTVSGTCKPGARLVDIAPSPNTNLAADLHVLIAGANDVASGMAGNIYKHLEPTIQNLLTSSKVIVSTLPLRYDVAPNSPINHSIRLINHYIAELCCRYKGVGLVDVRGIRRKDFTSHGMHLRHTGKEIWARLIIDQAAKLLHKTPVKQTPPSYPDLNQAVLIRTDEGTSSGCTPRTLPYANFAEALKKHPNCRDQENDKAVPSKDSPKNGNTAFYCDDKRVHFLDQPALADSQR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01372726;
80% Identity
-